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Stk3 Gene Detail
Summary
  • Symbol
    Stk3
  • Name
    serine/threonine kinase 3
  • Synonyms
    0610042I06Rik, mess1, MST, Mst2, Ste20
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928487
    NCBI Gene: 56274
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:34875645-35155990 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 14.34 cM, cytoband B3.3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5472 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928487
 protein coding gene Chr15:34875642-35179067 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021785
 protein coding gene Chr15:33223365-33517031 (-)
A/J MGP_AJ_G0021746
 protein coding gene Chr15:31955386-32245964 (-)
AKR/J MGP_AKRJ_G0021724
 protein coding gene Chr15:32805953-33091116 (-)
BALB/cJ MGP_BALBcJ_G0021752
 protein coding gene Chr15:31950339-32220961 (-)
C3H/HeJ MGP_C3HHeJ_G0021527
 protein coding gene Chr15:32791353-33084022 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022191
 protein coding gene Chr15:34470664-34784827 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019729
 protein coding gene Chr15:29824180-30095643 (-)
CAST/EiJ MGP_CASTEiJ_G0021043
 protein coding gene Chr15:33198966-33481456 (-)
CBA/J MGP_CBAJ_G0021496
 protein coding gene Chr15:35533016-35834591 (-)
DBA/2J MGP_DBA2J_G0021620
 protein coding gene Chr15:31752509-32038754 (-)
FVB/NJ MGP_FVBNJ_G0021598
 protein coding gene Chr15:31193068-31470729 (-)
LP/J MGP_LPJ_G0021689
 protein coding gene Chr15:33124353-33417094 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021623
 protein coding gene Chr15:38571164-38877851 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022214
 protein coding gene Chr15:32981364-33264945 (-)
PWK/PhJ MGP_PWKPhJ_G0020787
 protein coding gene Chr15:31800745-32072625 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020625
 protein coding gene Chr15:32677286-32944713 (-)
WSB/EiJ MGP_WSBEiJ_G0021099
 protein coding gene Chr15:32957052-33235105 (-)



Homology
more
  • Human Ortholog
    STK3, serine/threonine kinase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STK3, serine/threonine kinase 3
  • Synonyms
    KRS1, MST2
  • Links
    NCBI Gene ID: 6788
    neXtProt AC: NX_Q13188
    UniProt: Q13188

  • Chr Location
    8q22.2; chr8:98343975-98942827 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 4 alleles in 4 genetic backgrounds
    69 phenotypes from multigenic genotypes
    86 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene generally results in mice that are viable, fertile and developmentally normal. A small subset of mice homozygous for a knock-out allele develop mammary tumors in the absence of immunological defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    95
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    746
  • Tissues
    19
  • cDNA Data
    27
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56274 NCBI Gene Model | MGI Sequence Detail 280346 C57BL/6J ±  kb
    transcript NM_001357821 RefSeq | MGI Sequence Detail 2932 C57BL/6  
    polypeptide Q9JI10 UniProt | EBI | MGI Sequence Detail 497 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 28
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1914102
    References
    more
    • Summaries
      All 136
      Developmental Gene Expression 14
      Diseases 1
      Gene Ontology 17
      Phenotypes 86
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:355261 Rehmani T, et al., SLMAP3 is essential for neurulation through mechanisms involving cytoskeletal elements, ABP, and PCP. Life Sci Alliance. 2024 Dec;7(12)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory