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Htra2 Gene Detail
Summary
  • Symbol
    Htra2
  • Name
    HtrA serine peptidase 2
  • Synonyms
    HtrA2, mnd2, OMI, Prss25
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928676
    NCBI Gene: 64704
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:83028247-83031552 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 35.94 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    116 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928676
 protein coding gene Chr6:83028247-83032254 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030911
 protein coding gene Chr6:84054950-84058956 (-)
A/J MGP_AJ_G0030880
 protein coding gene Chr6:80841615-80845622 (-)
AKR/J MGP_AKRJ_G0030808
 protein coding gene Chr6:83171073-83175077 (-)
BALB/cJ MGP_BALBcJ_G0030890
 protein coding gene Chr6:80854573-80858577 (-)
C3H/HeJ MGP_C3HHeJ_G0030820
 protein coding gene Chr6:101208579-101212572 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031350
 protein coding gene Chr6:86334317-86338323 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028536
 protein coding gene Chr6:79200363-79204295 (-)
CAST/EiJ MGP_CASTEiJ_G0029999
 protein coding gene Chr6:83169624-83175162 (-)
CBA/J MGP_CBAJ_G0030577
 protein coding gene Chr6:89746589-89750596 (-)
DBA/2J MGP_DBA2J_G0030730
 protein coding gene Chr6:80161224-80165231 (-)
FVB/NJ MGP_FVBNJ_G0030683
 protein coding gene Chr6:79368941-79372948 (-)
LP/J MGP_LPJ_G0030809
 protein coding gene Chr6:84048848-84052856 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030719
 protein coding gene Chr6:94051348-94055354 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031374
 protein coding gene Chr6:82983815-82987832 (-)
PWK/PhJ MGP_PWKPhJ_G0029714
 protein coding gene Chr6:79053416-79057432 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029542
 protein coding gene Chr6:81827589-81834332 (-)
WSB/EiJ MGP_WSBEiJ_G0030080
 protein coding gene Chr6:83423392-83427413 (-)



Homology
more
  • Human Ortholog
    HTRA2, HtrA serine peptidase 2
  • Vertebrate Orthologs
    14
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HTRA2, HtrA serine peptidase 2
  • Synonyms
    MGCA8, OMI, PARK13, PRSS25
  • Links
    NCBI Gene ID: 27429
    neXtProt AC: NX_O43464
    UniProt: O43464

  • Chr Location
    2p13.1; chr2:74529405-74533556 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human HTRA2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    68 phenotypes from 5 alleles in 7 genetic backgrounds
    4 phenotypes from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutations of this gene cause progressive parkinsonian symptoms, loss of striatal neurons, spleen and thymus atrophy, failure to thrive, and death before 40 days of age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    87
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    741
  • Tissues
    22
  • cDNA Data
    7
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 64704 NCBI Gene Model | MGI Sequence Detail 3306 C57BL/6J ±  kb
    transcript NM_019752 RefSeq | MGI Sequence Detail 1739 ZRU/MplStud  
    polypeptide Q9JIY5 UniProt | EBI | MGI Sequence Detail 458 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      Genomic 1
      cDNA 8

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12335, MGI:2141430, MGI:97039
    References
    more
    • Summaries
      All 98
      Developmental Gene Expression 2
      Gene Ontology 18
      Phenotypes 40
    • Earliest
      J:12780 Jones JM, et al., mnd2: a new mouse model of inherited motor neuron disease. Genomics. 1993 Jun;16(3):669-77
    • Latest
      J:347601 Shen T, et al., Cardiac-specific deletion of heat shock protein 60 induces mitochondrial stress and disrupts heart development in mice. Biochem Biophys Res Commun. 2024 May 28;710:149883
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory