Slc4a8 MGI Mouse Gene Detail - MGI:1928745 - solute carrier family 4 (anion exchanger), member 8

Symbol

Slc4a8
Name

solute carrier family 4 (anion exchanger), member 8
Synonyms

KNBC-3, NDCBE, sodium bicarbonate cotransporter isoform 3 kNBC-3

Feature Type

protein coding gene
IDs

MGI:1928745
NCBI Gene: 59033
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr15:100659628-100721849 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 56.39 cM, cytoband F3
Mapping Data

3 experiments

SNPs within 2kb

1998 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1928745	protein coding gene	Chr15:100659628-100721852 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022361	protein coding gene	Chr15:102753305-102817559 (+)
A/J	MGP_AJ_G0022323	protein coding gene	Chr15:98704015-98761827 (+)
AKR/J	MGP_AKRJ_G0022299	protein coding gene	Chr15:101724528-101778559 (+)
BALB/cJ	MGP_BALBcJ_G0022327	protein coding gene	Chr15:98814354-98869266 (+)
C3H/HeJ	MGP_C3HHeJ_G0022097	protein coding gene	Chr15:101810665-101868107 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022775	protein coding gene	Chr15:106609652-106667250 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020300	protein coding gene	Chr15:94456210-94518750 (+)
CAST/EiJ	MGP_CASTEiJ_G0021622	protein coding gene	Chr15:102641803-102706683 (+)
CBA/J	MGP_CBAJ_G0022066	protein coding gene	Chr15:110269324-110334411 (+)
DBA/2J	MGP_DBA2J_G0022193	protein coding gene	Chr15:98054215-98107977 (+)
FVB/NJ	MGP_FVBNJ_G0022172	protein coding gene	Chr15:97087989-97147676 (+)
LP/J	MGP_LPJ_G0022264	protein coding gene	Chr15:102906936-102965803 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022193	protein coding gene	Chr15:113985628-114045547 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022789	protein coding gene	Chr15:101728211-101785913 (+)
PWK/PhJ	MGP_PWKPhJ_G0021361	protein coding gene	Chr15:98191174-98250156 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021193	protein coding gene	Chr15:101629816-101686476 (+)
WSB/EiJ	MGP_WSBEiJ_G0021672	protein coding gene	Chr15:102351159-102409454 (+)

Human Ortholog

SLC4A8, solute carrier family 4 member 8

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC4A8, solute carrier family 4 member 8
Synonyms

NBC3, NDCBE
Links

HGNC:11034

NCBI Gene ID: 9498

neXtProt AC: NX_Q2Y0W8

UniProt: Q2Y0W8
Chr Location

12q13.13; chr12:51391317-51515763 (+) GRCh38

MGI Vertebrate Homology

Slc4a8 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC4A8
Gene Tree

Slc4a8

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References

1 with disease annotations

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
35 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

3
Radiation induced

2
Targeted

4
Genomic Mutations

3 involving Slc4a8
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

55 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit abnormal sodium and chloride ion excretion.

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All GO Annotations

71
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

926
Tissues

145
cDNA Data

43
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc4a8

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All Sequences

64
RefSeq

6
UniProt

3
CCDS

CCDS37214.1, CCDS84193.1

Ensembl

ENSMUSG00000023032 (Evidence)
NCBI Gene

59033

			Length	Strain/Species	Flank
genomic	ENSMUSG00000023032	Ensembl Gene Model \| MGI Sequence Detail	62222	C57BL/6J	± kb
transcript	ENSMUST00000023776	Ensembl \| MGI Sequence Detail	11790	Not Applicable
polypeptide	ENSMUSP00000023776	Ensembl \| MGI Sequence Detail	1089	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000015163 electroneutral sodium bicarbonate exchanger 1

(term hierarchy)
InterPro Domains

IPR013769 Band 3 cytoplasmic domain

IPR003020 Bicarbonate transporter, eukaryotic

IPR011531 Bicarbonate transporter-like, transmembrane domain

IPR016152 Phosphotransferase/anion transporter

IPR003024 Sodium bicarbonate cotransporter
GlyGen

Q8JZR6 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)

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All nucleic 47

cDNA 45

Primer pair 2

Microarray probesets 7

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MGI:2146219

Summaries

All 69

Developmental Gene Expression 5

Diseases 1

Gene Ontology 11

Phenotypes 35
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:346895 Guo P, et al., A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis. Elife. 2024 Feb 12;13

TSS for Slc4a8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr133163	Chr15:100659622-100659678 (+)	22 bp
Tssr133164	Chr15:100659730-100659745 (+)	110 bp
Tssr133165	Chr15:100678124-100678128 (+)	18,498 bp
Tssr133166	Chr15:100681684-100681699 (+)	22,064 bp
Tssr4722	Chr15:100682228-100682229 (+)	22,601 bp
Tssr133167	Chr15:100688324-100688337 (+)	28,703 bp
Tssr133168	Chr15:100688728-100688734 (+)	29,103 bp
Tssr133169	Chr15:100708353-100708375 (+)	48,736 bp
Tssr133170	Chr15:100708468-100708482 (+)	48,847 bp
Tssr133171	Chr15:100712172-100712219 (+)	52,568 bp
Tssr4723	Chr15:100717442-100717484 (+)	57,835 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24