Sec1 MGI Mouse Gene Detail - MGI:1928893

Symbol

Sec1
Name

secretory blood group 1
Synonyms

Fut3, GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase FUT-III

Feature Type

protein coding gene
IDs

MGI:1928893
NCBI Gene: 56546
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr7:45327110-45343825 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 29.43 cM
Mapping Data

2 experiments

SNPs within 2kb

429 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1928893	protein coding gene	Chr7:45327110-45343826 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0032238	protein coding gene	Chr7:45982024-45998772 (-)
A/J	MGP_AJ_G0032217	protein coding gene	Chr7:45073052-45090383 (-)
AKR/J	MGP_AKRJ_G0032153	protein coding gene	Chr7:46320737-46337450 (-)
BALB/cJ	MGP_BALBcJ_G0032229	protein coding gene	Chr7:45066981-45083790 (-)
C3H/HeJ	MGP_C3HHeJ_G0031944	protein coding gene	Chr7:46818075-46835307 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0032721	protein coding gene	Chr7:48234233-48250946 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029735	protein coding gene	Chr7:47628439-47645250 (-)
CAST/EiJ	MGP_CASTEiJ_G0031273	protein coding gene	Chr7:38256443-38273181 (-)
CBA/J	MGP_CBAJ_G0031909	protein coding gene	Chr7:49840302-49857015 (-)
DBA/2J	MGP_DBA2J_G0032067	protein coding gene	Chr7:44751195-44767943 (-)
FVB/NJ	MGP_FVBNJ_G0032018	protein coding gene	Chr7:44524703-44542936 (-)
LP/J	MGP_LPJ_G0032145	protein coding gene	Chr7:46688813-46705510 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032055	protein coding gene	Chr7:48524688-48541401 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032737	protein coding gene	Chr7:45535810-45552619 (-)
PWK/PhJ	MGP_PWKPhJ_G0030995	protein coding gene	Chr7:38119538-38136360 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0030833	protein coding gene	Chr7:33558930-33578349 (-)
WSB/EiJ	MGP_WSBEiJ_G0031390	protein coding gene	Chr7:46040945-46057663 (-)

Human Ortholog

FUT2, fucosyltransferase 2 (H blood group)

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FUT2, fucosyltransferase 2 (H blood group)
Synonyms

B12QTL1, SE, Se2, SEC2, sej
Links

HGNC:4013

NCBI Gene ID: 2524

neXtProt AC: NX_Q10981

UniProt: Q10981
Chr Location

19q13.33; chr19:48695971-48705951 (+) GRCh38

Human Ortholog

SEC1P, secretory blood group 1, pseudogene
Synonyms

SEC1
Links

HGNC:44149

NCBI Gene ID: 653677
Chr Location

19q13.33; chr19:48638039-48682245 (+) GRCh38

MGI Vertebrate Homology

Sec1 stringent orthology
2 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: FUT2, SEC1P
Gene Tree

Sec1

Diseases

1 with human FUT2 associations

				Human Disease	Mouse Models
				vitamin B12 deficiency IDs vitamin B12 deficiency DOID:0050731 MESH:D014806

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

4
Gene trapped

2
Targeted

3
Genomic Mutations

1 involving Sec1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit decreased susceptibility to bacterial infection induced morbidity/mortality.

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All GO Annotations

15
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

1
cDNA Data

8
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

46
RefSeq

6
UniProt

4
CCDS

CCDS71963.1

Ensembl

ENSMUSG00000040364 (Evidence)
NCBI Gene

56546

			Length	Strain/Species	Flank
genomic	56546	NCBI Gene Model \| MGI Sequence Detail	16716	C57BL/6J	± kb
transcript	NM_001405895	RefSeq \| MGI Sequence Detail	2520	ZRU/MplStud
polypeptide	P97353	UniProt \| EBI \| MGI Sequence Detail	368	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000015924 galactoside 2-alpha-L-fucosyltransferase Sec1

(term hierarchy)
EC

2.4.1.-
InterPro Domains

IPR002516 Glycosyl transferase, family 11
GlyGen

P97353 3 sites

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All nucleic 9

cDNA 8

Primer pair 1

Microarray probesets 5

Summaries

All 37

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 12
Earliest

J:66377 Lin B, et al., GDP-fucose: beta-galactoside alpha1,2-fucosyltransferase, MFUT-II, and not MFUT-I or -III, is induced in a restricted region of the digestive tract of germ-free mice by host-microbe interactions and cycloheximide. Biochim Biophys Acta. 2000 Sep 27;1487(2-3):275-85
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Sec1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr72443	Chr7:45343793-45343830 (-)	13 bp
Tssr72442	Chr7:45343609-45343618 (-)	211 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24