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Arpc1a Gene Detail
Summary
  • Symbol
    Arpc1a
  • Name
    actin related protein 2/3 complex, subunit 1A
  • Synonyms
    0610010H08Rik, 1110030K07Rik, Sid32
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928896
    NCBI Gene: 56443
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:145020679-145045566 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 85.00 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    780 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928896
 protein coding gene Chr5:145020640-145045571 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030355
 protein coding gene Chr5:150505319-150530526 (+)
A/J MGP_AJ_G0030324
 protein coding gene Chr5:144039833-144065637 (+)
AKR/J MGP_AKRJ_G0030256
 protein coding gene Chr5:148512155-148543166 (+)
BALB/cJ MGP_BALBcJ_G0030341
 protein coding gene Chr5:145294458-145320273 (+)
C3H/HeJ MGP_C3HHeJ_G0030052
 protein coding gene Chr5:149338626-149365674 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030786
 protein coding gene Chr5:155995185-156027306 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028007
 protein coding gene Chr5:137777902-137801466 (+)
CAST/EiJ MGP_CASTEiJ_G0029457
 protein coding gene Chr5:148902917-148933109 (+)
CBA/J MGP_CBAJ_G0030022
 protein coding gene Chr5:162431996-162465744 (+)
DBA/2J MGP_DBA2J_G0030172
 protein coding gene Chr5:143755478-143780800 (+)
FVB/NJ MGP_FVBNJ_G0030127
 protein coding gene Chr5:142988595-143016093 (+)
LP/J MGP_LPJ_G0030261
 protein coding gene Chr5:151087919-151116411 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030158
 protein coding gene Chr5:164738465-164767020 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030826
 protein coding gene Chr5:148413694-148446607 (+)
PWK/PhJ MGP_PWKPhJ_G0029172
 protein coding gene Chr5:142904512-142929583 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029008
 protein coding gene Chr5:146163561-146193515 (+)
WSB/EiJ MGP_WSBEiJ_G0029532
 protein coding gene Chr5:149222063-149250880 (+)



Homology
more
  • Human Ortholog
    ARPC1A, actin related protein 2/3 complex subunit 1A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARPC1A, actin related protein 2/3 complex subunit 1A
  • Synonyms
    Arc40, HEL-68, HEL-S-307, SOP2Hs, SOP2L
  • Links
    NCBI Gene ID: 10552
    neXtProt AC: NX_Q92747
    UniProt: Q92747

  • Chr Location
    7q22.1; chr7:99325898-99366262 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ARPC1A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    747
  • Tissues
    27
  • cDNA Data
    225
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56443 NCBI Gene Model | MGI Sequence Detail 24888 C57BL/6J ±  kb
    transcript NM_019767 RefSeq | MGI Sequence Detail 1588 C57BL/6  
    polypeptide Q9R0Q6 UniProt | EBI | MGI Sequence Detail 370 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000004308 actin-related protein 2/3 complex subunit 1A
      (term hierarchy)
    • InterPro Domains
      IPR017383 Actin-related protein 2/3 complex subunit 1
      IPR001680 WD40 repeat
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    • GlyGen
      Q9R0Q6 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 227
      cDNA 227

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1914685, MGI:1924157, MGI:2140724
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory