Piwil1 MGI Mouse Gene Detail - MGI:1928897 - piwi-like RNA-mediated gene silencing 1

Symbol

Piwil1
Name

piwi-like RNA-mediated gene silencing 1
Synonyms

MIWI

Feature Type

protein coding gene
IDs

MGI:1928897
NCBI Gene: 57749
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr5:128813135-128832538 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 67.86 cM
Mapping Data

1 experiment

SNPs within 2kb

606 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1928897	protein coding gene	Chr5:128779588-128832538 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030120	protein coding gene	Chr5:132733095-132783319 (+)
A/J	MGP_AJ_G0030087	protein coding gene	Chr5:127156687-127210879 (+)
AKR/J	MGP_AKRJ_G0030021	protein coding gene	Chr5:131289367-131337498 (+)
BALB/cJ	MGP_BALBcJ_G0030097	protein coding gene	Chr5:128504843-128557509 (+)
C3H/HeJ	MGP_C3HHeJ_G0029814	protein coding gene	Chr5:131860151-131908435 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030550	protein coding gene	Chr5:137819007-137874447 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027775	protein coding gene	Chr5:121579807-121627094 (+)
CAST/EiJ	MGP_CASTEiJ_G0029223	protein coding gene	Chr5:131109361-131167364 (+)
CBA/J	MGP_CBAJ_G0029784	protein coding gene	Chr5:143201124-143255207 (+)
DBA/2J	MGP_DBA2J_G0029934	protein coding gene	Chr5:127148738-127195443 (+)
FVB/NJ	MGP_FVBNJ_G0029890	protein coding gene	Chr5:126201200-126258077 (+)
LP/J	MGP_LPJ_G0030023	protein coding gene	Chr5:133249597-133301020 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029921	protein coding gene	Chr5:146586962-146637071 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030591	protein coding gene	Chr5:130949194-131002246 (+)
PWK/PhJ	MGP_PWKPhJ_G0028937	protein coding gene	Chr5:126039874-126092764 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028774	protein coding gene	Chr5:128529308-128588205 (+)
WSB/EiJ	MGP_WSBEiJ_G0029297	protein coding gene	Chr5:131615538-131663971 (+)

Human Ortholog

PIWIL1, piwi like RNA-mediated gene silencing 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PIWIL1, piwi like RNA-mediated gene silencing 1
Synonyms

CT80.1, HIWI, MIWI, PIWI
Links

HGNC:9007

NCBI Gene ID: 9271

neXtProt AC: NX_Q96J94

UniProt: Q96J94
Chr Location

12q24.33; chr12:130337887-130426260 (+) GRCh38

MGI Vertebrate Homology

Piwil1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PIWIL1
Gene Tree

Piwil1

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Phenotype Summary

9 phenotypes from 3 alleles in 3 genetic backgrounds
34 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

4
Radiation induced

1
Targeted

4
Transgenic

2
Genomic Mutations

2 involving Piwil1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a targeted null mutation exhibit male sterility due to a block in spermatogenesis beginning at the round spermatid stage.

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All GO Annotations

51
GO References

29

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

842
Tissues

55
cDNA Data

21
Literature Summary

20

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA PIWIL1

Xenbase piwil1

ZFIN piwil1

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All Sequences

39
RefSeq

4
UniProt

2
CCDS

CCDS19690.1

Ensembl

ENSMUSG00000029423 (Evidence)
NCBI Gene

57749

			Length	Strain/Species	Flank
genomic	57749	NCBI Gene Model \| MGI Sequence Detail	19404	C57BL/6J	± kb
transcript	NM_021311	RefSeq \| MGI Sequence Detail	3944	ZRU/MplStud
polypeptide	Q9JMB7	UniProt \| EBI \| MGI Sequence Detail	862	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000012762 piwi-like protein 1

(term hierarchy)
PDB

2XFM, 4P1Z
EC

3.1.26.-
InterPro Domains

IPR014811 Argonaute, linker 1 domain

IPR031320 GAGE

IPR003100 PAZ domain

IPR036085 PAZ domain superfamily

IPR003165 Piwi domain

IPR012337 Ribonuclease H-like superfamily

IPR036397 Ribonuclease H superfamily

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All nucleic 25

cDNA 21

Primer pair 4

Microarray probesets 2

Summaries

All 101

Developmental Gene Expression 20

Gene Ontology 29

Phenotypes 34
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:357900 Cecchini K, et al., Mouse Pachytene piRNAs Cleave Hundreds of Transcripts, But Alter the Steady-State Abundance of Only a Minority of Targets. bioRxiv. 2024;

TSS for Piwil1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr48983	Chr5:128813150-128813157 (+)	19 bp
Tssr48984	Chr5:128813189-128813196 (+)	58 bp
Tssr1644	Chr5:128813224-128813225 (+)	90 bp
Tssr48985	Chr5:128813232-128813251 (+)	107 bp
Tssr48986	Chr5:128813306-128813311 (+)	174 bp
Tssr48987	Chr5:128832191-128832207 (+)	19,064 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24