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Tro Gene Detail
Summary
  • Symbol
    Tro
  • Name
    trophinin
  • Synonyms
    Maged3, Maged3l, magphinin, magphinin-alpha, magphinin-beta 2, magphinin-gamma, necdin and trophinin like, Tnn, Trol, trophinin-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928994
    NCBI Gene: 56191
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:149428300-149440579 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 68.46 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    177 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928994
 protein coding gene ChrX:149427706-149440579 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036171
 protein coding gene ChrX:148373688-148385548 (-)
A/J MGP_AJ_G0036147
 protein coding gene ChrX:147575445-147587087 (-)
AKR/J MGP_AKRJ_G0036073
 protein coding gene ChrX:152358528-152374220 (-)
BALB/cJ MGP_BALBcJ_G0036138
 protein coding gene ChrX:145772354-145784552 (-)
C3H/HeJ MGP_C3HHeJ_G0035846
 protein coding gene ChrX:148567074-148580046 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036663
 protein coding gene ChrX:152545130-152558324 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033487
 protein coding gene ChrX:139413885-139425914 (-)
CAST/EiJ MGP_CASTEiJ_G0035137
 protein coding gene ChrX:128015687-128031467 (-)
CBA/J MGP_CBAJ_G0035823
 protein coding gene ChrX:157102139-157114050 (-)
DBA/2J MGP_DBA2J_G0035981
 protein coding gene ChrX:146673607-146685894 (-)
FVB/NJ MGP_FVBNJ_G0035915
 protein coding gene ChrX:145820200-145833246 (-)
LP/J MGP_LPJ_G0036072
 protein coding gene ChrX:149434902-149446857 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035951
 protein coding gene ChrX:165147143-165160895 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036698
 protein coding gene ChrX:147881890-147895216 (-)
PWK/PhJ MGP_PWKPhJ_G0034831
 protein coding gene ChrX:124993526-125006020 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034657
 protein coding gene ChrX:128485433-128498180 (-)
WSB/EiJ MGP_WSBEiJ_G0035272
 protein coding gene ChrX:145966410-145979813 (-)



Homology
more
  • Human Ortholog
    TRO, trophinin
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRO, trophinin
  • Synonyms
    MAGE-d3, MAGED3
  • Links
    NCBI Gene ID: 7216
    neXtProt AC: NX_Q12816
    UniProt: Q12816

  • Chr Location
    Xp11.21; chrX:54920462-54931431 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 2 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous female or hemizygous male mice on a mixed 129 and NIH black Swiss background are viable, fertile and elderly mice exhibit no disorders. On an inbred 129 background, homozygous female or hemizygous male mice show partial embryonic lethality between E3.5 and E8.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    5
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    721
  • Tissues
    10
  • cDNA Data
    92
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025272 Ensembl Gene Model | MGI Sequence Detail 12280 C57BL/6J ±  kb
transcript ENSMUST00000087258 Ensembl | MGI Sequence Detail 6559 Not Applicable  
polypeptide ENSMUSP00000084513 Ensembl | MGI Sequence Detail 2087 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    17 Sequences
  • InterPro Domains
    IPR002190 MAGE homology domain
    IPR041898 MAGE homology domain, winged helix WH1 motif
    IPR041899 MAGE homology domain, winged helix WH2 motif
    IPR037445 Melanoma-associated antigen
Molecular
Reagents
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  • All nucleic 94
    cDNA 92
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGI:1929005, MGI:2147822
References
more
  • Summaries
    All 42
    Developmental Gene Expression 5
    Gene Ontology 2
    Phenotypes 5
  • Earliest
    J:66337 Suzuki N, et al., Trophinin expression in the mouse uterus coincides with implantation and is hormonally regulated but not induced by implanting blastocysts. Endocrinology. 2000 Nov;141(11):4247-54
  • Latest
    J:333289 Park SK, et al., Enhancement of mouse sperm motility by trophinin-binding peptide. Reprod Biol Endocrinol. 2012 Nov 29;10:101
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory