Stk4 MGI Mouse Gene Detail - MGI:1929004 - serine/threonine kinase 4

Symbol

Stk4
Name

serine/threonine kinase 4
Synonyms

Kas-2, Mst1, sterile 20-like kinase 1, Ysk3

Feature Type

protein coding gene
IDs

MGI:1929004
NCBI Gene: 58231
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr2:163916033-163997444 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 84.60 cM, cytoband H3
Mapping Data

3 experiments

SNPs within 2kb

2404 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929004	protein coding gene	Chr2:163912242-163997444 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026836	protein coding gene	Chr2:169449281-169547130 (+)
A/J	MGP_AJ_G0026802	protein coding gene	Chr2:162594845-162679556 (+)
AKR/J	MGP_AKRJ_G0026773	protein coding gene	Chr2:167411525-167502380 (+)
BALB/cJ	MGP_BALBcJ_G0026811	protein coding gene	Chr2:162935069-163022223 (+)
C3H/HeJ	MGP_C3HHeJ_G0026553	protein coding gene	Chr2:167763479-167856490 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027259	protein coding gene	Chr2:174394694-174481896 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024629	protein coding gene	Chr2:155903854-155990781 (+)
CAST/EiJ	MGP_CASTEiJ_G0026014	protein coding gene	Chr2:168179040-168279202 (+)
CBA/J	MGP_CBAJ_G0026530	protein coding gene	Chr2:180667236-180767642 (+)
DBA/2J	MGP_DBA2J_G0026668	protein coding gene	Chr2:161764161-161849298 (+)
FVB/NJ	MGP_FVBNJ_G0026634	protein coding gene	Chr2:160141240-160227480 (+)
LP/J	MGP_LPJ_G0026771	protein coding gene	Chr2:169557424-169647453 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026656	protein coding gene	Chr2:184336070-184429491 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027315	protein coding gene	Chr2:167312460-167402737 (+)
PWK/PhJ	MGP_PWKPhJ_G0025748	protein coding gene	Chr2:161337522-161427564 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025551	protein coding gene	Chr2:166191419-166277199 (+)
WSB/EiJ	MGP_WSBEiJ_G0026084	protein coding gene	Chr2:168176712-168268214 (+)

Human Ortholog

STK4, serine/threonine kinase 4

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

STK4, serine/threonine kinase 4
Synonyms

KRS2, MST1, YSK3
Links

HGNC:11408

NCBI Gene ID: 6789

neXtProt AC: NX_Q13043

UniProt: Q13043
Chr Location

20q13.12; chr20:44966494-45080021 (+) GRCh38

MGI Vertebrate Homology

Stk4 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: STK4
Gene Tree

Stk4

Diseases

1 with human STK4 associations

				Human Disease	Mouse Models
				primary immunodeficiency disease IDs primary immunodeficiency disease DOID:612 ICD10CM:D84.9 ICD9CM:279.3 KEGG:05340 MESH:D007153 NCI:C39725 OMIM:242850 OMIM:PS300755 UMLS_CUI:C0021051

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

55 phenotypes from 12 alleles in 14 genetic backgrounds
69 phenotypes from multigenic genotypes
118 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

58
Chemically induced (ENU)

7
Endonuclease-mediated

6
Gene trapped

32
Targeted

13
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

74 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trap allele have low numbers of nave T cells that are hyper-responsive to stimulation. Mice homozygous for knock-out alleles exhibit decreased peripheral T cell numbers due to impaired emigration and homing.

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All GO Annotations

107
GO References

22

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

737
Tissues

18
cDNA Data

136
Literature Summary

20

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase stk4

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All Sequences

55
RefSeq

6
UniProt

5
CCDS

CCDS17021.1

Ensembl

ENSMUSG00000018209 (Evidence)
NCBI Gene

58231

			Length	Strain/Species	Flank
genomic	58231	NCBI Gene Model \| MGI Sequence Detail	81412	C57BL/6J	± kb
transcript	NM_021420	RefSeq \| MGI Sequence Detail	5246	C57BL/6
polypeptide	Q9JI11	UniProt \| EBI \| MGI Sequence Detail	487	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000015757 serine/threonine-protein kinase 4

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR024205 Mst1/2 SARAH domain

IPR036674 p53-like tetramerisation domain superfamily

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR011524 SARAH domain

IPR050285 STE20 Serine/Threonine-Protein Kinase

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All nucleic 136

cDNA 136

Microarray probesets 5

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MGI:1203525, MGI:2138944, MGI:2139225

Summaries

All 191

Developmental Gene Expression 20

Diseases 1

Gene Ontology 22

Phenotypes 118
Earliest

J:29051 Bagrodia S, et al., Identification of a mouse p21Cdc42/Rac activated kinase [published erratum appears in J Biol Chem 1996 Jan 12;271(2):1250]. J Biol Chem. 1995 Sep 29;270(39):22731-7
Latest

J:358815 Guo ZF, et al., Inhibiting endothelial cell Mst1 attenuates acute lung injury in mice. JCI Insight. 2024 Sep 10;9(17)

TSS for Stk4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr21513	Chr2:163916022-163916037 (+)	-3 bp
Tssr21514	Chr2:163916042-163916138 (+)	57 bp
Tssr21515	Chr2:163919302-163919330 (+)	3,283 bp
Tssr21516	Chr2:163920027-163920066 (+)	4,014 bp
Tssr21517	Chr2:163920106-163920109 (+)	4,075 bp
Tssr21518	Chr2:163920369-163920372 (+)	4,338 bp
Tssr21519	Chr2:163926097-163926122 (+)	10,077 bp
Tssr21520	Chr2:163926526-163926539 (+)	10,500 bp
Tssr21521	Chr2:163926541-163926561 (+)	10,518 bp
Tssr21522	Chr2:163971794-163971799 (+)	55,764 bp
Tssr21523	Chr2:163996542-163996565 (+)	80,521 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24