Copz2 MGI Mouse Gene Detail - MGI:1929008 - coatomer protein complex, subunit zeta 2

Symbol

Copz2
Name

coatomer protein complex, subunit zeta 2
Synonyms

1110012D12Rik, nonclathrin coat protein zeta2-COP, zeta2-COP

Feature Type

protein coding gene
IDs

MGI:1929008
NCBI Gene: 56358
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr11:96740702-96752029 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 60.13 cM, cytoband D
Mapping Data

2 experiments

SNPs within 2kb

466 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929008	protein coding gene	Chr11:96740696-96752029 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019014	protein coding gene	Chr11:99204369-99215769 (+)
A/J	MGP_AJ_G0018982	protein coding gene	Chr11:95139894-95153131 (+)
AKR/J	MGP_AKRJ_G0018952	protein coding gene	Chr11:98092642-98104348 (+)
BALB/cJ	MGP_BALBcJ_G0018955	protein coding gene	Chr11:95640660-95652339 (+)
C3H/HeJ	MGP_C3HHeJ_G0018769	protein coding gene	Chr11:98214206-98227900 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019407	protein coding gene	Chr11:102285256-102299351 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017038	protein coding gene	Chr11:92619358-92631297 (+)
CAST/EiJ	MGP_CASTEiJ_G0018322	protein coding gene	Chr11:99056293-99069790 (+)
CBA/J	MGP_CBAJ_G0018740	protein coding gene	Chr11:106483594-106496141 (+)
DBA/2J	MGP_DBA2J_G0018848	protein coding gene	Chr11:94702912-94715026 (+)
FVB/NJ	MGP_FVBNJ_G0018837	protein coding gene	Chr11:94180630-94191940 (+)
LP/J	MGP_LPJ_G0018918	protein coding gene	Chr11:99727039-99738342 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018864	protein coding gene	Chr11:106428981-106440834 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019447	protein coding gene	Chr11:98389991-98401311 (+)
PWK/PhJ	MGP_PWKPhJ_G0018094	protein coding gene	Chr11:95672505-95684739 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017884	protein coding gene	Chr11:98122955-98134885 (+)
WSB/EiJ	MGP_WSBEiJ_G0018372	protein coding gene	Chr11:98299638-98311889 (+)

Human Ortholog

COPZ2, COPI coat complex subunit zeta 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

COPZ2, COPI coat complex subunit zeta 2
Synonyms

zeta2-COP
Links

HGNC:19356

NCBI Gene ID: 51226

neXtProt AC: NX_Q9P299

UniProt: Q9P299
Chr Location

17q21.32; chr17:48026167-48048053 (-) GRCh38

MGI Vertebrate Homology

Copz2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: COPZ2
Gene Tree

Copz2

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Phenotype Summary

10 phenotype references

All Mutations and Alleles

8
Endonuclease-mediated

1
Gene trapped

4
Targeted

3
Genomic Mutations

1 involving Copz2
Find Mice (IMSR)

13 strains or lines available

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All GO Annotations

11
GO References

6

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

7

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase copz2

ZFIN copz2

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All Sequences

46
RefSeq

2
UniProt

4
CCDS

CCDS25305.1

Ensembl

ENSMUSG00000018672 (Evidence)
NCBI Gene

56358

			Length	Strain/Species	Flank
genomic	56358	NCBI Gene Model \| MGI Sequence Detail	11328	C57BL/6J	± kb
transcript	NM_019877	RefSeq \| MGI Sequence Detail	937	Not Specified
polypeptide	Q9JHH9	UniProt \| EBI \| MGI Sequence Detail	205	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000005748 coatomer subunit zeta-2

(term hierarchy)
InterPro Domains

IPR022775 AP complex, mu/sigma subunit

IPR039652 Coatomer subunit zeta

IPR011012 Longin-like domain superfamily

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All nucleic 7

cDNA 7

Microarray probesets 3

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MGI:1915758

Summaries

All 37

Gene Ontology 6

Phenotypes 10
Earliest

J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
Latest

J:174216 Terzian T, et al., Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models. J Pathol. 2011 Aug;224(4):540-52

TSS for Copz2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr104577	Chr11:96740689-96740723 (+)	4 bp
Tssr104578	Chr11:96746080-96746098 (+)	5,387 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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