Rev1 MGI Mouse Gene Detail - MGI:1929074 - REV1, DNA directed polymerase

Symbol

Rev1
Name

REV1, DNA directed polymerase
Synonyms

1110027I23Rik, REV1, Rev1l

Feature Type

protein coding gene
IDs

MGI:1929074
NCBI Gene: 56210
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr1:38091867-38168882 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 16.46 cM, cytoband B
Mapping Data

3 experiments

SNPs within 2kb

1385 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929074	protein coding gene	Chr1:38091867-38169191 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0015949	protein coding gene	Chr1:36715257-36794545 (-)
A/J	MGP_AJ_G0015933	protein coding gene	Chr1:35700066-35786157 (-)
AKR/J	MGP_AKRJ_G0015888	protein coding gene	Chr1:36197618-36274413 (-)
BALB/cJ	MGP_BALBcJ_G0015887	protein coding gene	Chr1:35359051-35436909 (-)
C3H/HeJ	MGP_C3HHeJ_G0015720	protein coding gene	Chr1:36426736-36502353 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016340	protein coding gene	Chr1:38306729-38386702 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014062	protein coding gene	Chr1:32686534-32760157 (-)
CAST/EiJ	MGP_CASTEiJ_G0015301	protein coding gene	Chr1:36281916-36365194 (-)
CBA/J	MGP_CBAJ_G0015692	protein coding gene	Chr1:39363501-39445982 (-)
DBA/2J	MGP_DBA2J_G0015793	protein coding gene	Chr1:35005438-35082368 (-)
FVB/NJ	MGP_FVBNJ_G0015795	protein coding gene	Chr1:34534190-34611309 (-)
LP/J	MGP_LPJ_G0015863	protein coding gene	Chr1:37061562-37141031 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015815	protein coding gene	Chr1:41511095-41592230 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016387	protein coding gene	Chr1:36268157-36347431 (-)
PWK/PhJ	MGP_PWKPhJ_G0015084	protein coding gene	Chr1:34793063-34870965 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0014866	protein coding gene	Chr1:36217663-36297721 (-)
WSB/EiJ	MGP_WSBEiJ_G0015363	protein coding gene	Chr1:36227329-36303594 (-)

Human Ortholog

REV1, REV1 DNA directed polymerase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

REV1, REV1 DNA directed polymerase
Synonyms

AIBP80, REV1L
Links

HGNC:14060

NCBI Gene ID: 51455

neXtProt AC: NX_Q9UBZ9

UniProt: Q9UBZ9
Chr Location

2q11.2; chr2:99400475-99490202 (-) GRCh38

MGI Vertebrate Homology

Rev1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: REV1
Protein SuperFamily

REV1
Gene Tree

Rev1

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Phenotype Summary

6 phenotypes from 3 alleles in 2 genetic backgrounds
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

52
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

41
Targeted

5
Genomic Mutations

1 involving Rev1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

70 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-in allele exhibit abnormal somatic hypermutation frequency of the Ig gene. Mice homozygous for a knock-out allele exhibit background-sensitive prenatal lethality and abnormal somatic hypermutation frequency.

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All GO Annotations

13
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

6

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rev1

ZFIN rev1

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All Sequences

98
RefSeq

44
UniProt

7
CCDS

CCDS14899.1

Ensembl

ENSMUSG00000026082 (Evidence)
NCBI Gene

56210

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026082	Ensembl Gene Model \| MGI Sequence Detail	77016	C57BL/6J	± kb
transcript	ENSMUST00000027251	Ensembl \| MGI Sequence Detail	4262	Not Applicable
polypeptide	ENSMUSP00000027251	Ensembl \| MGI Sequence Detail	1249	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000013899 DNA repair protein REV1

(term hierarchy)
PDB

2LSG, 2LSJ, 4FJO, 6C59, 6C8C
EC

2.7.7.-
InterPro Domains

IPR001357 BRCT domain

IPR036420 BRCT domain superfamily

IPR017961 DNA polymerase, Y-family, little finger domain

IPR036775 DNA polymerase, Y-family, little finger domain superfamily

IPR012112 DNA repair protein Rev1

IPR031991 DNA repair protein Rev1, C-terminal

IPR047346 DNA repair protein REV1, ubiquitin-binding motif 1/2

IPR043502 DNA/RNA polymerase superfamily

IPR025527 HUWE1/REV1, ubiquitin-binding motif

IPR038401 Rev1, C-terminal domain superfamily

IPR043128 Reverse transcriptase/Diguanylate cyclase domain

IPR001126 UmuC domain

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All nucleic 6

cDNA 6

Microarray probesets 3

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MGI:1915914, MGI:2138468

Summaries

All 69

Gene Ontology 8

Phenotypes 30
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:348075 Shah P, et al., Primordial germ cell DNA demethylation and development require DNA translesion synthesis. Nat Commun. 2024 May 3;15(1):3734

TSS for Rev1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr11333	Chr1:38168800-38168882 (-)	41 bp
Tssr11332	Chr1:38168699-38168760 (-)	152 bp
Tssr11331	Chr1:38160126-38160130 (-)	8,754 bp
Tssr11330	Chr1:38151230-38151234 (-)	17,650 bp
Tssr11329	Chr1:38145911-38145912 (-)	22,970 bp
Tssr11328	Chr1:38099667-38099671 (-)	69,213 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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