Sap30 MGI Mouse Gene Detail - MGI:1929129 - sin3 associated polypeptide

Symbol

Sap30
Name

sin3 associated polypeptide
Synonyms

30kDa

Feature Type

protein coding gene
IDs

MGI:1929129
NCBI Gene: 60406
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr8:57935740-57940874 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 29.85 cM
Mapping Data

2 experiments

SNPs within 2kb

194 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929129	protein coding gene	Chr8:57935740-57940894 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033623	protein coding gene	Chr8:57211397-57216551 (-)
A/J	MGP_AJ_G0033605	protein coding gene	Chr8:54796641-54801795 (-)
AKR/J	MGP_AKRJ_G0033530	protein coding gene	Chr8:56426825-56431984 (-)
BALB/cJ	MGP_BALBcJ_G0033602	protein coding gene	Chr8:55119735-55124889 (-)
C3H/HeJ	MGP_C3HHeJ_G0033311	protein coding gene	Chr8:57081104-57086257 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0034118	protein coding gene	Chr8:59414979-59420132 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031066	protein coding gene	Chr8:50348060-50353455 (-)
CAST/EiJ	MGP_CASTEiJ_G0032637	protein coding gene	Chr8:56471042-56476197 (-)
CBA/J	MGP_CBAJ_G0033290	protein coding gene	Chr8:61530684-61535994 (-)
DBA/2J	MGP_DBA2J_G0033443	protein coding gene	Chr8:54605276-54610427 (-)
FVB/NJ	MGP_FVBNJ_G0033384	protein coding gene	Chr8:53963463-53968614 (-)
LP/J	MGP_LPJ_G0033531	protein coding gene	Chr8:57219882-57225035 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033428	protein coding gene	Chr8:63143207-63148661 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034136	protein coding gene	Chr8:56660397-56665549 (-)
PWK/PhJ	MGP_PWKPhJ_G0032345	protein coding gene	Chr8:53917320-53922498 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032181	protein coding gene	Chr8:55528199-55533387 (-)
WSB/EiJ	MGP_WSBEiJ_G0032753	protein coding gene	Chr8:56911118-56916283 (-)

Human Ortholog

SAP30, Sin3A associated protein 30

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SAP30, Sin3A associated protein 30
Links

HGNC:10532

NCBI Gene ID: 8819

neXtProt AC: NX_O75446

UniProt: O75446
Chr Location

4q34.1; chr4:173369969-173377532 (+) GRCh38

MGI Vertebrate Homology

Sap30 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SAP30
Gene Tree

Sap30

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

2
Targeted

1
Genomic Mutations

1 involving Sap30
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

29
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

780
Tissues

28
cDNA Data

73
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sap30

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All Sequences

35
RefSeq

2
UniProt

1
CCDS

CCDS22316.1

Ensembl

ENSMUSG00000031609 (Evidence)
NCBI Gene

60406

			Length	Strain/Species	Flank
genomic	60406	NCBI Gene Model \| MGI Sequence Detail	5135	C57BL/6J	± kb
transcript	NM_021788	RefSeq \| MGI Sequence Detail	1159	ZRU/MplStud
polypeptide	O88574	UniProt \| EBI \| MGI Sequence Detail	220	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000014448 histone deacetylase complex subunit SAP30

(term hierarchy)
PDB

2LD7
InterPro Domains

IPR024145 Histone deacetylase complex subunit SAP30/SAP30-like

IPR025718 Histone deacetylase complex subunit SAP30, Sin3 binding domain

IPR025717 Histone deacetylase complex subunit SAP30 zinc-finger

IPR038291 SAP30, C-terminal domain superfamily

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All nucleic 76

Genomic 1

cDNA 73

Primer pair 1

Other 1

Microarray probesets 3

Summaries

All 45

Developmental Gene Expression 6

Gene Ontology 11

Phenotypes 8
Earliest

J:66985 Laherty CD, et al., SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors. Mol Cell. 1998 Jul;2(1):33-42
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Sap30:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr81339	Chr8:57940835-57940905 (-)	4 bp
Tssr81338	Chr8:57940770-57940829 (-)	74 bp
Tssr81337	Chr8:57940725-57940734 (-)	144 bp
Tssr81336	Chr8:57940624-57940639 (-)	242 bp
Tssr81335	Chr8:57940597-57940612 (-)	269 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24