Cldn18 MGI Mouse Gene Detail - MGI:1929209

Symbol

Cldn18
Name

claudin 18

Feature Type

protein coding gene
IDs

MGI:1929209
NCBI Gene: 56492
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr9:99572849-99599320 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 52.00 cM, cytoband E3-F1
Mapping Data

1 experiment

SNPs within 2kb

1133 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929209	protein coding gene	Chr9:99571514-99599320 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0035174	protein coding gene	Chr9:101072311-101103795 (-)
A/J	MGP_AJ_G0035155	protein coding gene	Chr9:97507885-97537318 (-)
AKR/J	MGP_AKRJ_G0035087	protein coding gene	Chr9:99873260-99907415 (-)
BALB/cJ	MGP_BALBcJ_G0035148	protein coding gene	Chr9:97196875-97225201 (-)
C3H/HeJ	MGP_C3HHeJ_G0034858	protein coding gene	Chr9:100299481-100329373 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035668	protein coding gene	Chr9:103965125-103998512 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032567	protein coding gene	Chr9:95224402-95250795 (-)
CAST/EiJ	MGP_CASTEiJ_G0034169	protein coding gene	Chr9:100101685-100135862 (-)
CBA/J	MGP_CBAJ_G0034826	protein coding gene	Chr9:107537014-107569607 (-)
DBA/2J	MGP_DBA2J_G0034988	protein coding gene	Chr9:97015426-97044053 (-)
FVB/NJ	MGP_FVBNJ_G0034936	protein coding gene	Chr9:95833630-95861927 (-)
LP/J	MGP_LPJ_G0035064	protein coding gene	Chr9:101319369-101350013 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034975	protein coding gene	Chr9:109437067-109469118 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035690	protein coding gene	Chr9:100131517-100163299 (-)
PWK/PhJ	MGP_PWKPhJ_G0033876	protein coding gene	Chr9:97231539-97260516 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033711	protein coding gene	Chr9:100193921-100229155 (-)
WSB/EiJ	MGP_WSBEiJ_G0034289	protein coding gene	Chr9:100011940-100040769 (-)

Human Ortholog

CLDN18, claudin 18

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CLDN18, claudin 18
Synonyms

SFTA5, SFTPJ
Links

HGNC:2039

NCBI Gene ID: 51208

neXtProt AC: NX_P56856

UniProt: P56856
Chr Location

3q22.3; chr3:137998735-138033655 (+) GRCh38

MGI Vertebrate Homology

Cldn18 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CLDN18
Gene Tree

Cldn18

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Phenotype Summary

27 phenotypes from 3 alleles in 3 genetic backgrounds
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

4
Targeted

7
Genomic Mutations

1 involving Cldn18
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a knock-out allele exhibit increased bone resorption and osteoclast differentiation. Homozygotes for another knock-out allele have impaired alveolarization and alveolar epithelial barrier function.

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All GO Annotations

33
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

772
Tissues

35
cDNA Data

9
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cldn18

ZFIN cldn18

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All Sequences

47
RefSeq

8
UniProt

2
CCDS

CCDS23437.1, CCDS57692.1, CCDS57693.1, CCDS57694.1

Ensembl

ENSMUSG00000032473 (Evidence)
NCBI Gene

56492

			Length	Strain/Species	Flank
genomic	56492	NCBI Gene Model \| MGI Sequence Detail	26472	C57BL/6J	± kb
transcript	NM_001194922	RefSeq \| MGI Sequence Detail	2849	C57BL/6
polypeptide	P56857	UniProt \| EBI \| MGI Sequence Detail	264	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005545 claudin-18

(term hierarchy)
InterPro Domains

IPR006187 Claudin

IPR003928 Claudin-18

IPR017974 Claudin, conserved site

IPR004031 PMP-22/EMP/MP20/Claudin

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All nucleic 16

Genomic 1

cDNA 9

Primer pair 4

Other 2

Microarray probesets 3

Summaries

All 58

Developmental Gene Expression 12

Gene Ontology 12

Phenotypes 24
Earliest

J:72106 Niimi T, et al., claudin-18, a Novel Downstream Target Gene for the T/EBP/NKX2.1 Homeodomain Transcription Factor, Encodes Lung- and Stomach-Specific Isoforms through Alternative Splicing. Mol Cell Biol. 2001 Nov;21(21):7380-90
Latest

J:349432 De Sanctis F, et al., Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity. 2024 May 10;

TSS for Cldn18:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr91081	Chr9:99599312-99599327 (-)	0 bp
Tssr91080	Chr9:99592122-99592138 (-)	7,190 bp
Tssr91079	Chr9:99592058-99592075 (-)	7,253 bp
Tssr91078	Chr9:99592005-99592041 (-)	7,297 bp
Tssr91077	Chr9:99574623-99574635 (-)	24,691 bp
Tssr91076	Chr9:99574540-99574556 (-)	24,772 bp
Tssr91075	Chr9:99574232-99574257 (-)	25,075 bp
Tssr91074	Chr9:99573737-99573740 (-)	25,581 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24