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Snd1 Gene Detail
Summary
  • Symbol
    Snd1
  • Name
    staphylococcal nuclease and tudor domain containing 1
  • Synonyms
    p100 co-activator, Tudor-SN
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929266
    NCBI Gene: 56463
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:28480332-28935161 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 11.99 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9755 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929266
 protein coding gene Chr6:28475138-28935161 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030511
 protein coding gene Chr6:26209403-26681163 (+)
A/J MGP_AJ_G0030484
 protein coding gene Chr6:25104012-25560142 (+)
AKR/J MGP_AKRJ_G0030411
 protein coding gene Chr6:25936493-26400403 (+)
BALB/cJ MGP_BALBcJ_G0030494
 protein coding gene Chr6:25270076-25720031 (+)
C3H/HeJ MGP_C3HHeJ_G0030207
 protein coding gene Chr6:25923257-26399925 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030948
 protein coding gene Chr6:27010253-27487542 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028159
 protein coding gene Chr6:23332731-23776575 (+)
CAST/EiJ MGP_CASTEiJ_G0029609
 protein coding gene Chr6:25727338-26186181 (+)
CBA/J MGP_CBAJ_G0030185
 protein coding gene Chr6:27976783-28460037 (+)
DBA/2J MGP_DBA2J_G0030329
 protein coding gene Chr6:25057838-25507694 (+)
FVB/NJ MGP_FVBNJ_G0030283
 protein coding gene Chr6:24809529-25263163 (+)
LP/J MGP_LPJ_G0030416
 protein coding gene Chr6:26353479-26818997 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030319
 protein coding gene Chr6:30533756-31019768 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030978
 protein coding gene Chr6:25811903-26263758 (+)
PWK/PhJ MGP_PWKPhJ_G0029323
 protein coding gene Chr6:24586701-25033804 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029159
 protein coding gene Chr6:25503118-25985320 (+)
WSB/EiJ MGP_WSBEiJ_G0029685
 protein coding gene Chr6:25779745-26241793 (+)



Homology
more
  • Human Ortholog
    SND1, staphylococcal nuclease and tudor domain containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SND1, staphylococcal nuclease and tudor domain containing 1
  • Synonyms
    p100, TDRD11, TSN, Tudor-SN
  • Links
    NCBI Gene ID: 27044
    neXtProt AC: NX_Q7KZF4
    UniProt: Q7KZF4

  • Chr Location
    7q32.1; chr7:127652194-128092609 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit normal splenic T and B cell ratios and TH1 activity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    767
  • Tissues
    53
  • cDNA Data
    13
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56463 NCBI Gene Model | MGI Sequence Detail 454830 C57BL/6J ±  kb
    transcript NM_019776 RefSeq | MGI Sequence Detail 3482 C57BL/6  
    polypeptide Q78PY7 UniProt | EBI | MGI Sequence Detail 910 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000015326 staphylococcal nuclease domain-containing protein 1
      (term hierarchy)
    • EC
      3.1.31.1
    • InterPro Domains
      IPR016685 RNA-induced silencing complex, nuclease component Tudor-SN
      IPR035437 SNase-like, OB-fold superfamily
      IPR016071 Staphylococcal nuclease (SNase-like), OB-fold
      IPR002071 Thermonuclease active site
      IPR002999 Tudor domain
      IPR047386 Tudor domain-containing protein 11, Tudor domain
    • GlyGen
      Q78PY7 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 14
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2141543
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 5
      Gene Ontology 10
      Phenotypes 14
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:350553 Su C, et al., Tudor-SN promotes cardiomyocyte proliferation and neonatal heart regeneration through regulating the phosphorylation of YAP. Cell Commun Signal. 2024 Jun 28;22(1):345
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory