Tmem59 MGI Mouse Gene Detail - MGI:1929278

Symbol

Tmem59
Name

transmembrane protein 59
Synonyms

1110001M20Rik, 3110046P06Rik, D4Ertd20e, MTDCF1, thymic dendritic cell-derived factor 1

Feature Type

protein coding gene
IDs

MGI:1929278
NCBI Gene: 56374
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr4:107035827-107058193 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 50.12 cM, cytoband C7
Mapping Data

4 experiments

SNPs within 2kb

598 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929278	protein coding gene	Chr4:107035596-107058193 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028533	protein coding gene	Chr4:107852484-107876532 (+)
A/J	MGP_AJ_G0028496	protein coding gene	Chr4:103987149-104009718 (+)
AKR/J	MGP_AKRJ_G0028443	protein coding gene	Chr4:106531810-106554533 (+)
BALB/cJ	MGP_BALBcJ_G0028515	protein coding gene	Chr4:104178996-104203571 (+)
C3H/HeJ	MGP_C3HHeJ_G0028229	protein coding gene	Chr4:107280401-107306047 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028955	protein coding gene	Chr4:111728557-111755400 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026246	protein coding gene	Chr4:99265588-99287790 (+)
CAST/EiJ	MGP_CASTEiJ_G0027665	protein coding gene	Chr4:105094458-105119209 (+)
CBA/J	MGP_CBAJ_G0028198	protein coding gene	Chr4:115353386-115378692 (+)
DBA/2J	MGP_DBA2J_G0028346	protein coding gene	Chr4:103608099-103630838 (+)
FVB/NJ	MGP_FVBNJ_G0028314	protein coding gene	Chr4:102476447-102498974 (+)
LP/J	MGP_LPJ_G0028447	protein coding gene	Chr4:108051211-108074404 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028340	protein coding gene	Chr4:120646482-120669153 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028991	protein coding gene	Chr4:106775678-106799534 (+)
PWK/PhJ	MGP_PWKPhJ_G0027391	protein coding gene	Chr4:101852266-101875441 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027215	protein coding gene	Chr4:104168768-104191416 (+)
WSB/EiJ	MGP_WSBEiJ_G0027746	protein coding gene	Chr4:106951143-106974961 (+)

Human Ortholog

TMEM59, transmembrane protein 59

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEM59, transmembrane protein 59
Synonyms

C1orf8, DCF1, HSPC001, PRO195, UNQ169
Links

HGNC:1239

NCBI Gene ID: 9528

neXtProt AC: NX_Q9BXS4

UniProt: Q9BXS4
Chr Location

1p32.3; chr1:54026681-54053573 (-) GRCh38

MGI Vertebrate Homology

Tmem59 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TMEM59
Gene Tree

Tmem59

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Phenotype Summary

10 phenotypes from 1 allele in 2 genetic backgrounds
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

35
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

25
Radiation induced

1
Targeted

4
Genomic Mutations

4 involving Tmem59
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

26 strains or lines available

Mice homozygous for a null allele display reduced dendritic arborization, reduced miniature excitatory postsynaptic currents, and impaired memory formation.

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All GO Annotations

25
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

821
Tissues

25
cDNA Data

18
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmem59

ZFIN tmem59

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All Sequences

61
RefSeq

2
UniProt

4
CCDS

CCDS18432.1

Ensembl

ENSMUSG00000028618 (Evidence)
NCBI Gene

56374

			Length	Strain/Species	Flank
genomic	56374	NCBI Gene Model \| MGI Sequence Detail	22367	C57BL/6J	± kb
transcript	NM_029565	RefSeq \| MGI Sequence Detail	1562	ZRU/MplStud
polypeptide	Q9QY73	UniProt \| EBI \| MGI Sequence Detail	323	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000032244 transmembrane protein 59

(term hierarchy)
InterPro Domains

IPR022065 Uncharacterised protein family, TMEM59
GlyGen

Q9QY73 1 site, 1 N-linked glycan (1 site)

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All nucleic 20

cDNA 19

Primer pair 1

Microarray probesets 5

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MGI:1099824, MGI:1923537, MGI:1924236, MGI:2140215

Summaries

All 58

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 25
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:335210 Ma Z, et al., TMEM59 ablation leads to loss of olfactory sensory neurons and impairs olfactory functions via interaction with inflammation. Brain Behav Immun. 2023 Apr 13;111:151-168

TSS for Tmem59:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr1252	Chr4:107035566-107035614 (+)	-237 bp
Tssr38222	Chr4:107035615-107035663 (+)	-188 bp
Tssr38223	Chr4:107035857-107035868 (+)	36 bp
Tssr38224	Chr4:107035883-107035920 (+)	75 bp
Tssr38225	Chr4:107037053-107037057 (+)	1,228 bp
Tssr38226	Chr4:107057549-107057560 (+)	21,728 bp
Tssr38227	Chr4:107057769-107057806 (+)	21,961 bp
Tssr38228	Chr4:107057828-107057932 (+)	22,053 bp
Tssr38229	Chr4:107057953-107057975 (+)	22,137 bp
Tssr38230	Chr4:107057999-107058015 (+)	22,180 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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