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Amotl2 Gene Detail
Summary
  • Symbol
    Amotl2
  • Name
    angiomotin-like 2
  • Synonyms
    Lccp, MASCOT, mKIAA0989
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929286
    NCBI Gene: 56332
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:102594290-102610616 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 54.71 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    393 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929286
 protein coding gene Chr9:102593871-102610617 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035189
 protein coding gene Chr9:104294659-104311400 (+)
A/J MGP_AJ_G0035169
 protein coding gene Chr9:100553381-100570114 (+)
AKR/J MGP_AKRJ_G0035101
 protein coding gene Chr9:103031531-103048533 (+)
BALB/cJ MGP_BALBcJ_G0035162
 protein coding gene Chr9:100258557-100276311 (+)
C3H/HeJ MGP_C3HHeJ_G0034872
 protein coding gene Chr9:103430675-103448033 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035682
 protein coding gene Chr9:107205287-107222031 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032581
 protein coding gene Chr9:98140620-98157191 (+)
CAST/EiJ MGP_CASTEiJ_G0034184
 protein coding gene Chr9:103246531-103263284 (+)
CBA/J MGP_CBAJ_G0034841
 protein coding gene Chr9:110943765-110960511 (+)
DBA/2J MGP_DBA2J_G0035002
 protein coding gene Chr9:100044814-100061809 (+)
FVB/NJ MGP_FVBNJ_G0034950
 protein coding gene Chr9:98842850-98859585 (+)
LP/J MGP_LPJ_G0035078
 protein coding gene Chr9:104501231-104517976 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034989
 protein coding gene Chr9:112767600-112784341 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035704
 protein coding gene Chr9:103281512-103298262 (+)
PWK/PhJ MGP_PWKPhJ_G0033891
 protein coding gene Chr9:100287059-100309947 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033726
 protein coding gene Chr9:103322896-103339602 (+)
WSB/EiJ MGP_WSBEiJ_G0034304
 protein coding gene Chr9:103157153-103173869 (+)



Homology
more
  • Human Ortholog
    AMOTL2, angiomotin like 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AMOTL2, angiomotin like 2
  • Synonyms
    LCCP
  • Links
    NCBI Gene ID: 51421
    neXtProt AC: NX_Q9Y2J4
    UniProt: Q9Y2J4

  • Chr Location
    3q22.2; chr3:134355345-134375479 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Conditional homozygous knockout in endothelial cells during embryonic development leads to aortic restriction in the embryo.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    764
  • Tissues
    23
  • cDNA Data
    15
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56332 NCBI Gene Model | MGI Sequence Detail 16327 C57BL/6J ±  kb
    transcript NM_001421298 RefSeq | MGI Sequence Detail 4329 C57BL/6  
    polypeptide Q8K371 UniProt | EBI | MGI Sequence Detail 772 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 15
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2143321, MGI:2143406
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 12
      Gene Ontology 10
      Phenotypes 13
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:353626 Ohkawara B, et al., Transcriptome profile of subsynaptic myonuclei at the neuromuscular junction in embryogenesis. J Neurochem. 2024 Apr;168(4):342-354
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory