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Myoz1 Gene Detail
Summary
  • Symbol
    Myoz1
  • Name
    myozenin 1
  • Synonyms
    2310001N11Rik, calsarcin-2, FATZ
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929471
    NCBI Gene: 59011
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:20699175-20706608 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 11.53 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    294 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929471
 protein coding gene Chr14:20699170-20706608 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021040
 protein coding gene Chr14:13414753-13422238 (-)
A/J MGP_AJ_G0020989
 protein coding gene Chr14:13104963-13112944 (-)
AKR/J MGP_AKRJ_G0020966
 protein coding gene Chr14:13630112-13637494 (-)
BALB/cJ MGP_BALBcJ_G0020992
 protein coding gene Chr14:13207295-13215163 (-)
C3H/HeJ MGP_C3HHeJ_G0020776
 protein coding gene Chr14:13569725-13577139 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021425
 protein coding gene Chr14:13915035-13922470 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018993
 protein coding gene Chr14:13418057-13425272 (-)
CAST/EiJ MGP_CASTEiJ_G0020300
 protein coding gene Chr14:13332832-13341640 (-)
CBA/J MGP_CBAJ_G0020742
 protein coding gene Chr14:14620870-14632633 (-)
DBA/2J MGP_DBA2J_G0020865
 protein coding gene Chr14:12928549-12936015 (-)
FVB/NJ MGP_FVBNJ_G0020848
 protein coding gene Chr14:12823106-12830643 (-)
LP/J MGP_LPJ_G0020941
 protein coding gene Chr14:13641769-13649187 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020874
 protein coding gene Chr14:14401027-14410472 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021458
 protein coding gene Chr14:13421184-13429352 (-)
PWK/PhJ MGP_PWKPhJ_G0020049
 protein coding gene Chr14:12498571-12506030 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019871
 protein coding gene Chr14:13211882-13218110 (-)
WSB/EiJ MGP_WSBEiJ_G0020356
 protein coding gene Chr14:13403344-13410791 (-)



Homology
more
  • Human Ortholog
    MYOZ1, myozenin 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYOZ1, myozenin 1
  • Synonyms
    CS-2, FATZ, MYOZ
  • Links
    NCBI Gene ID: 58529
    neXtProt AC: NX_Q9NP98
    UniProt: Q9NP98

  • Chr Location
    10q22.2; chr10:73631612-73641474 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 3 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show reduced body weight and fast-twitch muscle mass, a fiber type shift toward more oxidative fibers, increased exercise capacity and calcineurin activity, and enhanced muscle regeneration after cardiotoxin injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    771
  • Tissues
    19
  • cDNA Data
    29
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000068697 Ensembl Gene Model | MGI Sequence Detail 7434 C57BL/6J ±  kb
    transcript ENSMUST00000090469 Ensembl | MGI Sequence Detail 1289 Not Applicable  
    polypeptide ENSMUSP00000087955 Ensembl | MGI Sequence Detail 296 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 30
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1916752, MGI:2145778
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 12
    • Earliest
      J:66484 Frey N, et al., Calsarcins, a novel family of sarcomeric calcineurin-binding proteins. Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14632-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory