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Slc22a21 Gene Detail
Summary
  • Symbol
    Slc22a21
  • Name
    solute carrier family 22 (organic cation transporter), member 21
  • Synonyms
    Octn3, Slc22a9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929481
    NCBI Gene: 56517
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:53840791-53871158 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 32.05 cM, cytoband B1.3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    916 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929481
 protein coding gene Chr11:53840780-53871159 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018308
 protein coding gene Chr11:53404903-53428905 (-)
A/J MGP_AJ_G0018277
 protein coding gene Chr11:51294314-51432787 (-)
AKR/J MGP_AKRJ_G0018246
 protein coding gene Chr11:53089140-53120539 (-)
BALB/cJ MGP_BALBcJ_G0018248
 protein coding gene Chr11:51647410-51763465 (-)
C3H/HeJ MGP_C3HHeJ_G0018059
 protein coding gene Chr11:52949543-53056689 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018700
 protein coding gene Chr11:55025935-55081441 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016350
 protein coding gene Chr11:48799764-48914139 (-)
CAST/EiJ MGP_CASTEiJ_G0017623
 protein coding gene Chr11:52980965-53083954 (-)
CBA/J MGP_CBAJ_G0018034
 protein coding gene Chr11:57527949-57673157 (-)
DBA/2J MGP_DBA2J_G0018143
 protein coding gene Chr11:51036396-51154890 (-)
FVB/NJ MGP_FVBNJ_G0018135
 protein coding gene Chr11:50751941-50794704 (-)
LP/J MGP_LPJ_G0018218
 protein coding gene Chr11:53841521-53884517 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018160
 protein coding gene Chr11:58878228-58920093 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018742
 protein coding gene Chr11:53089472-53136371 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0017671
 protein coding gene Chr11:52728262-52774602 (-)



Homology
more
  • Human Ortholog
    SLC22A5, solute carrier family 22 member 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC22A5, solute carrier family 22 member 5
  • Synonyms
    CDSP, OCTN2
  • Links
    NCBI Gene ID: 6584
    neXtProt AC: NX_O76082
    UniProt: O76082

  • Chr Location
    5q31.1; chr5:132369710-132395613 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human SLC22A5 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit no detectable phenotypic abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    726
  • Tissues
    13
  • cDNA Data
    19
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000063652 Ensembl Gene Model | MGI Sequence Detail 30368 C57BL/6J ±  kb
    transcript ENSMUST00000076493 Ensembl | MGI Sequence Detail 3461 Not Applicable  
    polypeptide ENSMUSP00000075814 Ensembl | MGI Sequence Detail 564 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000015961 solute carrier family 22 member 21
      (term hierarchy)
    • InterPro Domains
      IPR005828 Major facilitator, sugar transporter-like
      IPR020846 Major facilitator superfamily domain
      IPR036259 MFS transporter superfamily
      IPR004749 Organic cation transport protein/SVOP
      IPR005829 Sugar transporter, conserved site
    • GlyGen
      Q9WTN6 5 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 19
      Primer pair 3

      Microarray probesets 4
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 11
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory