Dap3 MGI Mouse Gene Detail - MGI:1929538 - death associated protein 3

Symbol

Dap3
Name

death associated protein 3
Synonyms

4921514D13Rik, DAP-3

Feature Type

protein coding gene
IDs

MGI:1929538
NCBI Gene: 65111
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr3:88828110-88858488 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 39.01 cM, cytoband F2
Mapping Data

3 experiments

SNPs within 2kb

736 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929538	protein coding gene	Chr3:88828110-88858504 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027411	protein coding gene	Chr3:89097016-89124527 (-)
A/J	MGP_AJ_G0027375	protein coding gene	Chr3:86160961-86188150 (-)
AKR/J	MGP_AKRJ_G0027339	protein coding gene	Chr3:88242627-88270039 (-)
BALB/cJ	MGP_BALBcJ_G0027384	protein coding gene	Chr3:86129375-86156831 (-)
C3H/HeJ	MGP_C3HHeJ_G0027126	protein coding gene	Chr3:88438686-88466000 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027830	protein coding gene	Chr3:92451761-92479510 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025182	protein coding gene	Chr3:81644403-81675857 (-)
CAST/EiJ	MGP_CASTEiJ_G0026572	protein coding gene	Chr3:88785559-88817108 (-)
CBA/J	MGP_CBAJ_G0027100	protein coding gene	Chr3:95645202-95678124 (-)
DBA/2J	MGP_DBA2J_G0027238	protein coding gene	Chr3:85539732-85567143 (-)
FVB/NJ	MGP_FVBNJ_G0027206	protein coding gene	Chr3:83875512-83903626 (-)
LP/J	MGP_LPJ_G0027347	protein coding gene	Chr3:90168594-90211360 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027226	protein coding gene	Chr3:101867079-101895727 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027889	protein coding gene	Chr3:87989851-88018609 (-)
PWK/PhJ	MGP_PWKPhJ_G0026306	protein coding gene	Chr3:85409509-85437989 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026125	protein coding gene	Chr3:87151110-87181327 (-)
WSB/EiJ	MGP_WSBEiJ_G0026654	protein coding gene	Chr3:88374003-88405631 (-)

Human Ortholog

DAP3, death associated protein 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DAP3, death associated protein 3
Synonyms

bMRP-10, DAP-3, MRP-S29, MRPS29, mS29, S29mt
Links

HGNC:2673

NCBI Gene ID: 7818

neXtProt AC: NX_P51398

UniProt: P51398
Chr Location

1q22; chr1:155687948-155739010 (+) GRCh38

MGI Vertebrate Homology

Dap3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DAP3
Gene Tree

Dap3

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References

1 with disease annotations

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

27
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

24
Radiation induced

1
Genomic Mutations

2 involving Dap3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display embryonic lethality with defects in mitochondria morphology.

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All GO Annotations

11
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

761
Tissues

55
cDNA Data

158
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dap3

ZFIN dap3

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All Sequences

92
RefSeq

28
UniProt

10
CCDS

CCDS17486.2, CCDS50955.1, CCDS89651.1

Ensembl

ENSMUSG00000068921 (Evidence)
NCBI Gene

65111

			Length	Strain/Species	Flank
genomic	ENSMUSG00000068921	Ensembl Gene Model \| MGI Sequence Detail	30379	C57BL/6J	± kb
transcript	ENSMUST00000090938	Ensembl \| MGI Sequence Detail	4760	Not Applicable
polypeptide	ENSMUSP00000088456	Ensembl \| MGI Sequence Detail	396	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000006275 small ribosomal subunit protein mS29

(term hierarchy)
PDB

7PNT, 7PNU, 7PNV, 7PNW
InterPro Domains

IPR019368 Small ribosomal subunit protein mS29

IPR008092 Small ribosomal subunit protein mS29, metazoan-type
GlyGen

Q9ER88 1 site, 1 O-linked glycan (1 site)

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All nucleic 159

cDNA 159

Microarray probesets 3

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MGI:1913973

Summaries

All 42

Developmental Gene Expression 2

Diseases 1

Gene Ontology 7

Phenotypes 12
Earliest

J:65635 Berger T, et al., The apoptosis mediator mDAP-3 is a novel member of a conserved family of mitochondrial proteins. J Cell Sci. 2000 Oct;113(Pt 20):3603-12
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dap3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr34079	Chr3:88858453-88858520 (-)	1 bp
Tssr34078	Chr3:88858426-88858440 (-)	55 bp
Tssr34077	Chr3:88858397-88858422 (-)	78 bp
Tssr34076	Chr3:88857783-88857891 (-)	651 bp
Tssr34075	Chr3:88857708-88857739 (-)	764 bp
Tssr34074	Chr3:88857588-88857628 (-)	880 bp
Tssr34073	Chr3:88857499-88857528 (-)	974 bp
Tssr34072	Chr3:88857460-88857497 (-)	1,009 bp
Tssr34071	Chr3:88857244-88857296 (-)	1,218 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24