Stard3 MGI Mouse Gene Detail - MGI:1929618 - StAR related lipid transfer domain containing 3

Symbol

Stard3
Name

StAR related lipid transfer domain containing 3
Synonyms

es64, Mln64

Feature Type

protein coding gene
IDs

MGI:1929618
NCBI Gene: 59045
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr11:98249245-98271938 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 61.75 cM, cytoband D
Mapping Data

1 experiment

SNPs within 2kb

595 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929618	protein coding gene	Chr11:98249194-98271938 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019055	protein coding gene	Chr11:100896486-100920519 (+)
A/J	MGP_AJ_G0019023	protein coding gene	Chr11:96705049-96728105 (+)
AKR/J	MGP_AKRJ_G0018993	protein coding gene	Chr11:99696055-99722636 (+)
BALB/cJ	MGP_BALBcJ_G0018996	protein coding gene	Chr11:97195533-97219778 (+)
C3H/HeJ	MGP_C3HHeJ_G0018810	protein coding gene	Chr11:99832355-99856419 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019449	protein coding gene	Chr11:103969866-104000441 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017080	protein coding gene	Chr11:94144476-94167562 (+)
CAST/EiJ	MGP_CASTEiJ_G0018364	protein coding gene	Chr11:100707453-100729755 (+)
CBA/J	MGP_CBAJ_G0018781	protein coding gene	Chr11:108288377-108310864 (+)
DBA/2J	MGP_DBA2J_G0018889	protein coding gene	Chr11:96246603-96269516 (+)
FVB/NJ	MGP_FVBNJ_G0018878	protein coding gene	Chr11:95755061-95777711 (+)
LP/J	MGP_LPJ_G0018959	protein coding gene	Chr11:101375333-101399453 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018905	protein coding gene	Chr11:108088888-108112691 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019489	protein coding gene	Chr11:100028282-100050810 (+)
PWK/PhJ	MGP_PWKPhJ_G0018136	protein coding gene	Chr11:97253795-97276635 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017926	protein coding gene	Chr11:99733593-99755919 (+)
WSB/EiJ	MGP_WSBEiJ_G0018414	protein coding gene	Chr11:99938559-99961086 (+)

Human Ortholog

STARD3, StAR related lipid transfer domain containing 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

STARD3, StAR related lipid transfer domain containing 3
Synonyms

CAB1, es64, MLN64
Links

HGNC:17579

NCBI Gene ID: 10948

neXtProt AC: NX_Q14849

UniProt: Q14849
Chr Location

17q12; chr17:39637090-39664201 (+) GRCh38

MGI Vertebrate Homology

Stard3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: STARD3
Gene Tree

Stard3

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

28
Endonuclease-mediated

3
Gene trapped

19
Targeted

6
Genomic Mutations

1 involving Stard3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a truncated allele are viable and fertile and display mild defects in cholesterol metabolism.

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All GO Annotations

32
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

803
Tissues

96
cDNA Data

10
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase stard3

ZFIN stard3

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All Sequences

58
RefSeq

14
UniProt

2
CCDS

CCDS25345.1

Ensembl

ENSMUSG00000018167 (Evidence)
NCBI Gene

59045

			Length	Strain/Species	Flank
genomic	59045	NCBI Gene Model \| MGI Sequence Detail	22694	C57BL/6J	± kb
transcript	NM_001425640	RefSeq \| MGI Sequence Detail	2108	C57BL/6
polypeptide	Q61542	UniProt \| EBI \| MGI Sequence Detail	446	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000015718 StAR-related lipid transfer protein 3

(term hierarchy)
InterPro Domains

IPR019498 MENTAL domain

IPR029867 StAR-related lipid transfer protein 3, C-terminal

IPR051869 StAR-related Lipid Transfer (STARD3)

IPR002913 START domain

IPR023393 START-like domain superfamily

IPR000799 Steroidogenic acute regulatory protein-like
GlyGen

Q61542 1 site, 1 O-linked glycan (1 site)

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All nucleic 10

cDNA 10

Microarray probesets 3

Summaries

All 44

Developmental Gene Expression 2

Gene Ontology 9

Phenotypes 15
Earliest

J:51120 Tomasetto C, et al., Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17. Genomics. 1995 Aug 10;28(3):367-76
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Stard3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr104726	Chr11:98247538-98247552 (+)	-1,700 bp
Tssr104727	Chr11:98247553-98247564 (+)	-1,686 bp
Tssr104728	Chr11:98247864-98247905 (+)	-1,360 bp
Tssr104729	Chr11:98249210-98249226 (+)	-27 bp
Tssr104730	Chr11:98249228-98249283 (+)	11 bp
Tssr104731	Chr11:98249511-98249551 (+)	286 bp
Tssr104732	Chr11:98262618-98262637 (+)	13,383 bp
Tssr104733	Chr11:98262800-98262811 (+)	13,561 bp
Tssr104734	Chr11:98268805-98268816 (+)	19,566 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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