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Tbk1 Gene Detail
Summary
  • Symbol
    Tbk1
  • Name
    TANK-binding kinase 1
  • Synonyms
    1200008B05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929658
    NCBI Gene: 56480
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:121382360-121422692 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 69.84 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1281 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929658
 protein coding gene Chr10:121382360-121422699 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017783
 protein coding gene Chr10:124820350-124871860 (-)
A/J MGP_AJ_G0017758
 protein coding gene Chr10:119842439-119877753 (-)
AKR/J MGP_AKRJ_G0017721
 protein coding gene Chr10:123421464-123459273 (-)
BALB/cJ MGP_BALBcJ_G0017722
 protein coding gene Chr10:120239119-120277781 (-)
C3H/HeJ MGP_C3HHeJ_G0017546
 protein coding gene Chr10:123633483-123672443 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018177
 protein coding gene Chr10:129077281-129116197 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015857
 protein coding gene Chr10:114171590-114208000 (-)
CAST/EiJ MGP_CASTEiJ_G0017106
 protein coding gene Chr10:124015645-124055445 (-)
CBA/J MGP_CBAJ_G0017515
 protein coding gene Chr10:134330308-134376367 (-)
DBA/2J MGP_DBA2J_G0017621
 protein coding gene Chr10:118967852-119007913 (-)
FVB/NJ MGP_FVBNJ_G0017616
 protein coding gene Chr10:117963472-117998577 (-)
LP/J MGP_LPJ_G0017695
 protein coding gene Chr10:125358053-125398003 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017645
 protein coding gene Chr10:136851587-136892473 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018217
 protein coding gene Chr10:123467022-123509932 (-)
PWK/PhJ MGP_PWKPhJ_G0016891
 protein coding gene Chr10:119093857-119133288 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016682
 protein coding gene Chr10:122345256-122382201 (-)
WSB/EiJ MGP_WSBEiJ_G0017167
 protein coding gene Chr10:123673491-123713309 (-)



Homology
more
  • Human Ortholog
    TBK1, TANK binding kinase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TBK1, TANK binding kinase 1
  • Synonyms
    AIARV, FTDALS4, IIAE8, NAK, T2K
  • Links
    NCBI Gene ID: 29110
    neXtProt AC: NX_Q9UHD2
    UniProt: Q9UHD2

  • Chr Location
    12q14.2; chr12:64452090-64502114 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human TBK1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    48 phenotypes from 5 alleles in 6 genetic backgrounds
    9 phenotypes from multigenic genotypes
    81 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality. Mice homozygous for a different knock-out allele exhibit increased prenatal lethality, increased infiltration of mononuclear and/or granulomatous cells in multiple organs and tissues at 3 months of age, and increased lethality in response to LPS.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    91
  • GO References
    30
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    824
  • Tissues
    109
  • cDNA Data
    95
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020115 Ensembl Gene Model | MGI Sequence Detail 40333 C57BL/6J ±  kb
    transcript ENSMUST00000020316 Ensembl | MGI Sequence Detail 3024 Not Applicable  
    polypeptide ENSMUSP00000020316 Ensembl | MGI Sequence Detail 729 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 96
      cDNA 95
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1914699, MGI:2143617, MGI:2143800
    References
    more
    • Summaries
      All 194
      Developmental Gene Expression 6
      Gene Ontology 30
      Phenotypes 81
    • Earliest
      J:66310 Pomerantz JL, et al., NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase. EMBO J. 1999 Dec 1;18(23):6694-704
    • Latest
      J:357636 Cao M, et al., Inhibiting NF-kappaB inducing kinase improved the motor performance of ALS animal model. Brain Res. 2024 Nov 15;1843:149124
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory