Sorcs1 MGI Mouse Gene Detail - MGI:1929666 - sortilin-related VPS10 domain containing receptor 1

Symbol

Sorcs1
Name

sortilin-related VPS10 domain containing receptor 1

Feature Type

protein coding gene
IDs

MGI:1929666
NCBI Gene: 58178
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr19:50131737-50667084 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 45.05 cM, cytoband D2
Mapping Data

3 experiments

SNPs within 2kb

17664 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929666	protein coding gene	Chr19:50131733-50668030 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025240	protein coding gene	Chr19:50141483-50690023 (-)
A/J	MGP_AJ_G0025216	protein coding gene	Chr19:47616640-48164439 (-)
AKR/J	MGP_AKRJ_G0025185	protein coding gene	Chr19:49167215-49718544 (-)
BALB/cJ	MGP_BALBcJ_G0025211	protein coding gene	Chr19:47690714-48220653 (-)
C3H/HeJ	MGP_C3HHeJ_G0024971	protein coding gene	Chr19:49315431-49871238 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025654	protein coding gene	Chr19:51334287-51888483 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023066	protein coding gene	Chr19:46717704-47240177 (-)
CAST/EiJ	MGP_CASTEiJ_G0024435	protein coding gene	Chr19:49201958-49757723 (-)
CBA/J	MGP_CBAJ_G0024951	protein coding gene	Chr19:53893914-54468526 (-)
DBA/2J	MGP_DBA2J_G0025083	protein coding gene	Chr19:47446592-47972770 (-)
FVB/NJ	MGP_FVBNJ_G0025044	protein coding gene	Chr19:47203148-47725597 (-)
LP/J	MGP_LPJ_G0025169	protein coding gene	Chr19:50000816-50548507 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025075	protein coding gene	Chr19:53186253-53768912 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025712	protein coding gene	Chr19:49300589-49857894 (-)
PWK/PhJ	MGP_PWKPhJ_G0024184	protein coding gene	Chr19:47378418-47908059 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023987	protein coding gene	Chr19:47982614-48552229 (-)
WSB/EiJ	MGP_WSBEiJ_G0024506	protein coding gene	Chr19:49433570-49984366 (-)

Human Ortholog

SORCS1, sortilin related VPS10 domain containing receptor 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SORCS1, sortilin related VPS10 domain containing receptor 1
Synonyms

hSorCS
Links

HGNC:16697

NCBI Gene ID: 114815

neXtProt AC: NX_Q8WY21

UniProt: Q8WY21
Chr Location

10q25.1; chr10:106573663-107181138 (-) GRCh38

MGI Vertebrate Homology

Sorcs1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SORCS1
Gene Tree

Sorcs1

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

3
Gene trapped

1
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

80 strains or lines available

Female mice homozygous for a null allele have abnormal amyloid beta levels in the brain.

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All GO Annotations

6
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1072
Tissues

111
cDNA Data

30
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

65
RefSeq

18
UniProt

8
CCDS

CCDS84451.1, CCDS84452.1, CCDS84453.1

Ensembl

ENSMUSG00000043531 (Evidence)
NCBI Gene

58178

			Length	Strain/Species	Flank
genomic	ENSMUSG00000043531	Ensembl Gene Model \| MGI Sequence Detail	535348	C57BL/6J	± kb
transcript	ENSMUST00000209413	Ensembl \| MGI Sequence Detail	4398	Not Applicable
polypeptide	ENSMUSP00000147463	Ensembl \| MGI Sequence Detail	1192	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000032338 VPS10 domain-containing receptor SorCS1

(term hierarchy)
InterPro Domains

IPR013783 Immunoglobulin-like fold

IPR000601 PKD domain

IPR035986 PKD domain superfamily

IPR031777 Sortilin, C-terminal

IPR031778 Sortilin, N-terminal

IPR006581 VPS10

IPR050310 VPS10-related sortilin family receptors

IPR015943 WD40/YVTN repeat-like-containing domain superfamily
GlyGen

Q9JLC4 13 sites, 11 N-linked glycans (7 sites), 1 O-linked glycan (1 site)

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All nucleic 37

cDNA 33

Primer pair 4

Microarray probesets 4

Summaries

All 38

Developmental Gene Expression 5

Gene Ontology 4

Phenotypes 7
Earliest

J:66294 Hermey G, et al., Identification and characterization of SorCS, a third member of a novel receptor family. Biochem Biophys Res Commun. 1999 Dec 20;266(2):347-51
Latest

J:281663 Ribeiro LF, et al., SorCS1-mediated sorting in dendrites maintains neurexin axonal surface polarization required for synaptic function. PLoS Biol. 2019 Oct;17(10):e3000466

TSS for Sorcs1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr159791	Chr19:50667150-50667171 (-)	-77 bp
Tssr159790	Chr19:50667080-50667140 (-)	-26 bp
Tssr159789	Chr19:50667015-50667024 (-)	64 bp
Tssr159788	Chr19:50608654-50608660 (-)	58,427 bp
Tssr159787	Chr19:50561612-50561616 (-)	105,470 bp
Tssr159786	Chr19:50444232-50444235 (-)	222,850 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24