Mllt11 MGI Mouse Gene Detail - MGI:1929671 - myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11

Symbol

Mllt11
Name

myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11
Synonyms

Af1q

Feature Type

protein coding gene
IDs

MGI:1929671
NCBI Gene: 56772
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr3:95126446-95139482 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 40.74 cM
Mapping Data

2 experiments

SNPs within 2kb

277 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929671	protein coding gene	Chr3:95125852-95139486 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027575	protein coding gene	Chr3:95925482-95939709 (-)
A/J	MGP_AJ_G0027534	protein coding gene	Chr3:92961024-92974211 (-)
AKR/J	MGP_AKRJ_G0027501	protein coding gene	Chr3:95106675-95120322 (-)
BALB/cJ	MGP_BALBcJ_G0027546	protein coding gene	Chr3:92737265-92752198 (-)
C3H/HeJ	MGP_C3HHeJ_G0027279	protein coding gene	Chr3:95393222-95406555 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027994	protein coding gene	Chr3:99492999-99506046 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025334	protein coding gene	Chr3:89322689-89335721 (-)
CAST/EiJ	MGP_CASTEiJ_G0026729	protein coding gene	Chr3:94671829-94687778 (-)
CBA/J	MGP_CBAJ_G0027256	protein coding gene	Chr3:103098916-103111939 (-)
DBA/2J	MGP_DBA2J_G0027395	protein coding gene	Chr3:92252718-92266481 (-)
FVB/NJ	MGP_FVBNJ_G0027366	protein coding gene	Chr3:90325421-90341692 (-)
LP/J	MGP_LPJ_G0027504	protein coding gene	Chr3:97230382-97245233 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027393	protein coding gene	Chr3:109216198-109230694 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028048	protein coding gene	Chr3:94763467-94777513 (-)
PWK/PhJ	MGP_PWKPhJ_G0026457	protein coding gene	Chr3:92130751-92144477 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026278	protein coding gene	Chr3:93057993-93070940 (-)
WSB/EiJ	MGP_WSBEiJ_G0026811	protein coding gene	Chr3:95147397-95161373 (-)

Human Ortholog

MLLT11, MLLT11 transcription factor 7 cofactor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MLLT11, MLLT11 transcription factor 7 cofactor
Synonyms

AF1Q
Links

HGNC:16997

NCBI Gene ID: 10962

neXtProt AC: NX_Q13015

UniProt: Q13015
Chr Location

1q21.3; chr1:151060397-151069544 (+) GRCh38

MGI Vertebrate Homology

Mllt11 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MLLT11
Gene Tree

Mllt11

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References

1 with disease annotations

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Phenotype Summary

10 phenotypes from 1 allele in 1 genetic background
2 phenotypes from multigenic genotypes
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

89
Chemically induced (other)

1
Gene trapped

83
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Mllt11
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

46 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

25
GO References

6

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

967
Tissues

95
cDNA Data

9
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mllt11

ZFIN mllt11

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All Sequences

45
RefSeq

8
UniProt

2
CCDS

CCDS38544.1

Ensembl

ENSMUSG00000053192 (Evidence)
NCBI Gene

56772

			Length	Strain/Species	Flank
genomic	ENSMUSG00000053192	Ensembl Gene Model \| MGI Sequence Detail	13037	C57BL/6J	± kb
transcript	ENSMUST00000065482	Ensembl \| MGI Sequence Detail	1923	Not Applicable
polypeptide	ENSMUSP00000066448	Ensembl \| MGI Sequence Detail	90	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000010451 protein AF1q

(term hierarchy)
InterPro Domains

IPR026778 MLLT11 family

IPR033461 Putative WW-binding domain and destruction box

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All nucleic 12

cDNA 9

Primer pair 2

Other 1

Microarray probesets 4

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MGI:2139804

Summaries

All 46

Developmental Gene Expression 9

Diseases 1

Gene Ontology 6

Phenotypes 15
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:346886 Blommers M, et al., Cerebellar granule cell migration and folia development require Mllt11/Af1q/Tcf7c. Dev Neurobiol. 2024 Mar 20;

TSS for Mllt11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr34450	Chr3:95139478-95139491 (-)	-3 bp
Tssr34449	Chr3:95139472-95139476 (-)	8 bp
Tssr34448	Chr3:95137705-95137730 (-)	1,764 bp
Tssr34447	Chr3:95136792-95136819 (-)	2,676 bp
Tssr34446	Chr3:95136191-95136219 (-)	3,277 bp
Tssr34445	Chr3:95136181-95136190 (-)	3,296 bp
Tssr34444	Chr3:95135947-95136030 (-)	3,493 bp
Tssr34443	Chr3:95135904-95135942 (-)	3,559 bp
Tssr34442	Chr3:95135643-95135650 (-)	3,835 bp
Tssr34441	Chr3:95135602-95135615 (-)	3,873 bp
Tssr34440	Chr3:95135586-95135597 (-)	3,890 bp
Tssr34439	Chr3:95135573-95135584 (-)	3,903 bp
Tssr34438	Chr3:95135480-95135572 (-)	3,956 bp
Tssr34437	Chr3:95135458-95135475 (-)	4,015 bp
Tssr34436	Chr3:95127530-95127543 (-)	11,945 bp
Tssr34435	Chr3:95127438-95127498 (-)	12,014 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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