About   Help   FAQ
Arl3 Gene Detail
Summary
  • Symbol
    Arl3
  • Name
    ADP-ribosylation factor-like 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929699
    NCBI Gene: 56350
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:46519548-46561621 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 38.94 cM, cytoband D1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1319 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929699
 protein coding gene Chr19:46519535-46561637 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025211
 protein coding gene Chr19:46249553-46305737 (-)
A/J MGP_AJ_G0025187
 protein coding gene Chr19:43951820-43994642 (-)
AKR/J MGP_AKRJ_G0025156
 protein coding gene Chr19:45376694-45426656 (-)
BALB/cJ MGP_BALBcJ_G0025182
 protein coding gene Chr19:44007853-44050665 (-)
C3H/HeJ MGP_C3HHeJ_G0024942
 protein coding gene Chr19:45548120-45594258 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025625
 protein coding gene Chr19:47376253-47421852 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023039
 protein coding gene Chr19:43194029-43239877 (-)
CAST/EiJ MGP_CASTEiJ_G0024407
 protein coding gene Chr19:45356385-45409498 (-)
CBA/J MGP_CBAJ_G0024922
 protein coding gene Chr19:49757739-49814391 (-)
DBA/2J MGP_DBA2J_G0025054
 protein coding gene Chr19:43770279-43813952 (-)
FVB/NJ MGP_FVBNJ_G0025015
 protein coding gene Chr19:43555195-43599060 (-)
LP/J MGP_LPJ_G0025140
 protein coding gene Chr19:46145796-46199511 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025046
 protein coding gene Chr19:49090514-49146151 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025683
 protein coding gene Chr19:45492927-45540587 (-)
PWK/PhJ MGP_PWKPhJ_G0024156
 protein coding gene Chr19:43724442-43767393 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023960
 protein coding gene Chr19:44135377-44186616 (-)
WSB/EiJ MGP_WSBEiJ_G0024477
 protein coding gene Chr19:45637573-45687227 (-)



Homology
more
  • Human Ortholog
    ARL3, ARF like GTPase 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARL3, ARF like GTPase 3
  • Synonyms
    ARFL3, JBTS35, RP83
  • Links
    NCBI Gene ID: 403
    neXtProt AC: NX_P36405
    UniProt: P36405

  • Chr Location
    10q24.32; chr10:102673731-102714397 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Arl3 mouse models; 2 with human ARL3 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 4 alleles in 5 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele are born at sub-Mendelian ratios, are small and sickly, fail to thrive, and die by 3 weeks of age exhibiting photoreceptor degeneration and abnormal epithelial cell proliferation and cyst formation in the kidney,liver, and pancreatic tubule structures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    722
  • Tissues
    9
  • cDNA Data
    100
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56350 NCBI Gene Model | MGI Sequence Detail 42074 C57BL/6J ±  kb
    transcript NM_001355233 RefSeq | MGI Sequence Detail 987 C57BL/6  
    polypeptide Q9WUL7 UniProt | EBI | MGI Sequence Detail 182 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 101
      cDNA 101

      Microarray probesets 2
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 2
      Diseases 2
      Gene Ontology 18
      Phenotypes 12
    • Earliest
      J:66311 Linari M, et al., The delta subunit of rod specific cyclic GMP phosphodiesterase, PDE delta, interacts with the Arf-like protein Arl3 in a GTP specific manner. FEBS Lett. 1999 Sep 10;458(1):55-9
    • Latest
      J:334916 Ma X, et al., A stress-induced cilium-to-PML-NB route drives senescence initiation. Nat Commun. 2023 Apr 3;14(1):1840
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory