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Metap2 Gene Detail
Summary
  • Symbol
    Metap2
  • Name
    methionine aminopeptidase 2
  • Synonyms
    4930584B20Rik, A930035J23Rik, eIF-2-associated p67, p67
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929701
    NCBI Gene: 56307
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:93694351-93732952 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 48.69 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1177 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929701
 protein coding gene Chr10:93694351-93732955 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017658
 protein coding gene Chr10:95294783-95339287 (-)
A/J MGP_AJ_G0017637
 protein coding gene Chr10:91971084-92010321 (-)
AKR/J MGP_AKRJ_G0017595
 protein coding gene Chr10:94595908-94636738 (-)
BALB/cJ MGP_BALBcJ_G0017600
 protein coding gene Chr10:92238678-92278400 (-)
C3H/HeJ MGP_C3HHeJ_G0017423
 protein coding gene Chr10:94596985-94635577 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018057
 protein coding gene Chr10:98458061-98499317 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015738
 protein coding gene Chr10:87555726-87594524 (-)
CAST/EiJ MGP_CASTEiJ_G0016988
 protein coding gene Chr10:94591905-94630587 (-)
CBA/J MGP_CBAJ_G0017392
 protein coding gene Chr10:102521585-102564561 (-)
DBA/2J MGP_DBA2J_G0017498
 protein coding gene Chr10:91060695-91101562 (-)
FVB/NJ MGP_FVBNJ_G0017490
 protein coding gene Chr10:90289209-90329205 (-)
LP/J MGP_LPJ_G0017572
 protein coding gene Chr10:95903781-95950823 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017521
 protein coding gene Chr10:103794157-103837216 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018094
 protein coding gene Chr10:94504808-94544720 (-)
PWK/PhJ MGP_PWKPhJ_G0016769
 protein coding gene Chr10:91157549-91196486 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016556
 protein coding gene Chr10:93284833-93352588 (-)
WSB/EiJ MGP_WSBEiJ_G0017047
 protein coding gene Chr10:94470172-94509652 (-)



Homology
more
  • Human Ortholog
    METAP2, methionyl aminopeptidase 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    METAP2, methionyl aminopeptidase 2
  • Synonyms
    MAP2, MNPEP, p67eIF2
  • Links
    NCBI Gene ID: 10988
    neXtProt AC: NX_P50579
    UniProt: P50579

  • Chr Location
    12q22; chr12:95473520-95515839 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in embryonic lethality around E8.5, smaller size, failure to gastrulate, reduced cell proliferation and absence of a distinct mesoderm.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    8
  • cDNA Data
    22
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56307 NCBI Gene Model | MGI Sequence Detail 38602 C57BL/6J ±  kb
    transcript NM_019648 RefSeq | MGI Sequence Detail 4990 C57BL/6  
    polypeptide O08663 UniProt | EBI | MGI Sequence Detail 478 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000010337 methionine aminopeptidase 2
      (term hierarchy)
    • EC
      3.4.11.18
    • InterPro Domains
      IPR036005 Creatinase/aminopeptidase-like
      IPR050247 Methionine Aminopeptidase Type 2
      IPR000994 Peptidase M24
      IPR002468 Peptidase M24A, methionine aminopeptidase, subfamily 2
      IPR018349 Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site
      IPR001714 Peptidase M24, methionine aminopeptidase
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    • GlyGen
      O08663 2 sites, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 24
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1923115, MGI:1925609, MGI:2143717, MGI:2144066, MGI:2144355
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 14
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory