Xpo7 MGI Mouse Gene Detail - MGI:1929705

Symbol

Xpo7
Name

exportin 7
Synonyms

4930506C02Rik, Ranbp16

Feature Type

protein coding gene
IDs

MGI:1929705
NCBI Gene: 65246
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr14:70899566-71004075 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 36.44 cM, cytoband D1
Mapping Data

3 experiments

SNPs within 2kb

1924 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929705	protein coding gene	Chr14:70891686-71004075 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021549	protein coding gene	Chr14:65320122-65430772 (-)
A/J	MGP_AJ_G0021508	protein coding gene	Chr14:63923159-64027773 (-)
AKR/J	MGP_AKRJ_G0021484	protein coding gene	Chr14:65840730-65952466 (-)
BALB/cJ	MGP_BALBcJ_G0021514	protein coding gene	Chr14:63686740-63793248 (-)
C3H/HeJ	MGP_C3HHeJ_G0021291	protein coding gene	Chr14:65558250-65667889 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021953	protein coding gene	Chr14:68227730-68338994 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019493	protein coding gene	Chr14:61762079-61865334 (-)
CAST/EiJ	MGP_CASTEiJ_G0020808	protein coding gene	Chr14:62153278-62262353 (-)
CBA/J	MGP_CBAJ_G0021258	protein coding gene	Chr14:70382217-70496240 (-)
DBA/2J	MGP_DBA2J_G0021381	protein coding gene	Chr14:63310523-63417711 (-)
FVB/NJ	MGP_FVBNJ_G0021360	protein coding gene	Chr14:62738711-62846355 (-)
LP/J	MGP_LPJ_G0021452	protein coding gene	Chr14:66564718-66669433 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021389	protein coding gene	Chr14:69260089-69379768 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021977	protein coding gene	Chr14:65103052-65213402 (-)
PWK/PhJ	MGP_PWKPhJ_G0020552	protein coding gene	Chr14:60078727-60185728 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020385	protein coding gene	Chr14:61035124-61139362 (-)
WSB/EiJ	MGP_WSBEiJ_G0020861	protein coding gene	Chr14:65414272-65525794 (-)

Human Ortholog

XPO7, exportin 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

XPO7, exportin 7
Synonyms

EXP7, RANBP16
Links

HGNC:14108

NCBI Gene ID: 23039

neXtProt AC: NX_Q9UIA9

UniProt: Q9UIA9
Chr Location

8p21.3; chr8:21919662-22006585 (+) GRCh38

MGI Vertebrate Homology

Xpo7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: XPO7
Gene Tree

Xpo7

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Phenotype Summary

13 phenotypes from 4 alleles in 4 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

42
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

31
Targeted

7
Genomic Mutations

1 involving Xpo7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

82 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit impaired stress erythropoiesis, mild anemia, and partial lethality during organogenesis.

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All GO Annotations

17
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

732
Tissues

7
cDNA Data

24
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase xpo7

ZFIN xpo7

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All Sequences

74
RefSeq

10
UniProt

3
CCDS

CCDS36974.1, CCDS88710.1

Ensembl

ENSMUSG00000022100 (Evidence)
NCBI Gene

65246

			Length	Strain/Species	Flank
genomic	65246	NCBI Gene Model \| MGI Sequence Detail	104510	C57BL/6J	± kb
transcript	NM_023045	RefSeq \| MGI Sequence Detail	7245	C57BL/6
polypeptide	Q9EPK7	UniProt \| EBI \| MGI Sequence Detail	1087	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000017501 exportin-7

(term hierarchy)
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR044189 Exportin 4/7-like

IPR001494 Importin-beta, N-terminal domain
GlyGen

Q9EPK7 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 29

cDNA 26

Primer pair 3

Microarray probesets 8

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MGI:1922351, MGI:2145856

Summaries

All 43

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 12
Earliest

J:65836 Koch P, et al., Identification of a novel putative ran-binding protein and its close homologue. Biochem Biophys Res Commun. 2000 Nov 11;278(1):241-9
Latest

J:331429 Modepalli S, et al., An In Vivo Model for Elucidating the Role of an Erythroid-Specific Isoform of Nuclear Export Protein Exportin 7 (Xpo7) in Murine Erythropoiesis. Exp Hematol. 2022 Aug 13;

TSS for Xpo7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr129645	Chr14:71004038-71004084 (-)	14 bp
Tssr129644	Chr14:71003974-71004004 (-)	86 bp
Tssr129643	Chr14:70991995-70991996 (-)	12,079 bp
Tssr129642	Chr14:70945474-70945477 (-)	58,599 bp
Tssr129641	Chr14:70945457-70945470 (-)	58,611 bp
Tssr129640	Chr14:70945434-70945451 (-)	58,632 bp
Tssr4472	Chr14:70945418-70945426 (-)	58,653 bp
Tssr129639	Chr14:70914774-70914780 (-)	89,298 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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