Asb1 MGI Mouse Gene Detail - MGI:1929735 - ankyrin repeat and SOCS box-containing 1

Symbol

Asb1
Name

ankyrin repeat and SOCS box-containing 1
Synonyms

1700029O08Rik, 1700054C17Rik, mKIAA1146

Feature Type

protein coding gene
IDs

MGI:1929735
NCBI Gene: 65247
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr1:91468266-91487311 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 46.19 cM
Mapping Data

4 experiments

SNPs within 2kb

444 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929735	protein coding gene	Chr1:91467725-91487312 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016312	protein coding gene	Chr1:93079232-93099777 (+)
A/J	MGP_AJ_G0016293	protein coding gene	Chr1:89732607-89751762 (+)
AKR/J	MGP_AKRJ_G0016254	protein coding gene	Chr1:92394034-92415295 (+)
BALB/cJ	MGP_BALBcJ_G0016249	protein coding gene	Chr1:89917706-89936778 (+)
C3H/HeJ	MGP_C3HHeJ_G0016078	protein coding gene	Chr1:92619777-92638842 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016708	protein coding gene	Chr1:96642870-96664149 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014426	protein coding gene	Chr1:83985303-84004438 (+)
CAST/EiJ	MGP_CASTEiJ_G0015663	protein coding gene	Chr1:91966153-91985304 (+)
CBA/J	MGP_CBAJ_G0016054	protein coding gene	Chr1:99740429-99762544 (+)
DBA/2J	MGP_DBA2J_G0016157	protein coding gene	Chr1:88958388-88977805 (+)
FVB/NJ	MGP_FVBNJ_G0016156	protein coding gene	Chr1:87997140-88016312 (+)
LP/J	MGP_LPJ_G0016228	protein coding gene	Chr1:94253523-94269688 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016181	protein coding gene	Chr1:102976037-102995109 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016748	protein coding gene	Chr1:92416044-92430574 (+)
PWK/PhJ	MGP_PWKPhJ_G0015447	protein coding gene	Chr1:88373374-88392977 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015230	protein coding gene	Chr1:91341288-91360591 (+)
WSB/EiJ	MGP_WSBEiJ_G0015721	protein coding gene	Chr1:92221221-92244098 (+)

Human Ortholog

ASB1, ankyrin repeat and SOCS box containing 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ASB1, ankyrin repeat and SOCS box containing 1
Synonyms

ASB-1
Links

HGNC:16011

NCBI Gene ID: 51665

neXtProt AC: NX_Q9Y576

UniProt: Q9Y576
Chr Location

2q37.3; chr2:238426742-238452250 (+) GRCh38

MGI Vertebrate Homology

Asb1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ASB1
Gene Tree

Asb1

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Phenotype Summary

15 phenotypes from 2 alleles in 2 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

6
Gene trapped

2
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Asb1
Incidental Mutations

APF
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in spleen hypocellularity, decreased spermatogenesis, and thickening of the skin in male animals.

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All GO Annotations

11
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

11

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ASB1

Xenbase asb1

ZFIN asb1

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All Sequences

83
RefSeq

8
UniProt

10
CCDS

CCDS35665.1, CCDS35666.1

Ensembl

ENSMUSG00000026311 (Evidence)
NCBI Gene

65247

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026311	Ensembl Gene Model \| MGI Sequence Detail	19046	C57BL/6J	± kb
transcript	ENSMUST00000086843	Ensembl \| MGI Sequence Detail	2490	Not Applicable
polypeptide	ENSMUSP00000084054	Ensembl \| MGI Sequence Detail	336	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000004341 ankyrin repeat and SOCS box protein 1

(term hierarchy)
InterPro Domains

IPR002110 Ankyrin repeat

IPR037331 Ankyrin repeat and SOCS box protein 1, SOCS box domain

IPR036770 Ankyrin repeat-containing domain superfamily

IPR050842 Cul2-RING E3 Ligase Substrate-Recognition Fem-1

IPR001496 SOCS box domain

IPR036036 SOCS box-like domain superfamily

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All nucleic 12

cDNA 12

Microarray probesets 8

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MGI:1917320, MGI:1920684, MGI:2138228, MGI:2138356

Summaries

All 45

Gene Ontology 6

Phenotypes 16
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Asb1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8095	Chr1:91466455-91466494 (+)	-1,791 bp
Tssr8096	Chr1:91467728-91467731 (+)	-536 bp
Tssr8097	Chr1:91467733-91467742 (+)	-528 bp
Tssr8098	Chr1:91467747-91467773 (+)	-506 bp
Tssr8099	Chr1:91467776-91467779 (+)	-488 bp
Tssr8100	Chr1:91468275-91468300 (+)	22 bp
Tssr8101	Chr1:91468409-91468483 (+)	180 bp
Tssr8102	Chr1:91468766-91468771 (+)	503 bp
Tssr8103	Chr1:91468796-91468811 (+)	538 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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