Asb2 MGI Mouse Gene Detail - MGI:1929743 - ankyrin repeat and SOCS box-containing 2

Symbol

Asb2
Name

ankyrin repeat and SOCS box-containing 2
Synonyms

1110008E15Rik

Feature Type

protein coding gene
IDs

MGI:1929743
NCBI Gene: 65256
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

Chr12:103287401-103322260 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 52.90 cM
Mapping Data

3 experiments

SNPs within 2kb

911 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929743	protein coding gene	Chr12:103287401-103322260 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020046	protein coding gene	Chr12:104999869-105034904 (-)
A/J	MGP_AJ_G0020002	protein coding gene	Chr12:100962284-100996908 (-)
AKR/J	MGP_AKRJ_G0019978	protein coding gene	Chr12:103809028-103843529 (-)
BALB/cJ	MGP_BALBcJ_G0019988	protein coding gene	Chr12:101317853-101352686 (-)
C3H/HeJ	MGP_C3HHeJ_G0019790	protein coding gene	Chr12:104300495-104336432 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020437	protein coding gene	Chr12:108255005-108298182 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018050	protein coding gene	Chr12:98002623-98037774 (-)
CAST/EiJ	MGP_CASTEiJ_G0019336	protein coding gene	Chr12:99152315-99189912 (-)
CBA/J	MGP_CBAJ_G0019762	protein coding gene	Chr12:112284256-112322992 (-)
DBA/2J	MGP_DBA2J_G0019873	protein coding gene	Chr12:100481575-100516769 (-)
FVB/NJ	MGP_FVBNJ_G0019862	protein coding gene	Chr12:99216889-99252301 (-)
LP/J	MGP_LPJ_G0019949	protein coding gene	Chr12:104846818-104882915 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019902	protein coding gene	Chr12:115739409-115776579 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020466	protein coding gene	Chr12:103346770-103382567 (-)
PWK/PhJ	MGP_PWKPhJ_G0019099	protein coding gene	Chr12:95043858-95079626 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018895	protein coding gene	Chr12:97546119-97583226 (-)
WSB/EiJ	MGP_WSBEiJ_G0019390	protein coding gene	Chr12:104231866-104268527 (-)

Human Ortholog

ASB2, ankyrin repeat and SOCS box containing 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ASB2, ankyrin repeat and SOCS box containing 2
Synonyms

ASB-2
Links

HGNC:16012

NCBI Gene ID: 51676

neXtProt AC: NX_Q96Q27

UniProt: Q96Q27
Chr Location

14q32.12; chr14:93934166-93976739 (-) GRCh38

MGI Vertebrate Homology

Asb2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ASB2
Gene Tree

Asb2

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Phenotype Summary

20 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

3
Targeted

7
Genomic Mutations

1 involving Asb2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a conditional cells activated in the immune system exhibit impaired immature dendritic cell migration.

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All GO Annotations

36
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

880
Tissues

46
cDNA Data

10
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ASB2

Xenbase asb2

ZFIN asb2b

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All Sequences

42
RefSeq

4
UniProt

1
CCDS

CCDS26128.1, CCDS88394.1

Ensembl

ENSMUSG00000021200 (Evidence)
NCBI Gene

65256

			Length	Strain/Species	Flank
genomic	65256	NCBI Gene Model \| MGI Sequence Detail	34860	C57BL/6J	± kb
transcript	NM_023049	RefSeq \| MGI Sequence Detail	2707	FVB/N
polypeptide	Q8K0L0	UniProt \| EBI \| MGI Sequence Detail	634	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000004351 ankyrin repeat and SOCS box protein 2

(term hierarchy)
InterPro Domains

IPR002110 Ankyrin repeat

IPR036770 Ankyrin repeat-containing domain superfamily

IPR001496 SOCS box domain

IPR036036 SOCS box-like domain superfamily

IPR003903 Ubiquitin interacting motif

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All nucleic 15

Genomic 1

cDNA 10

Primer pair 3

Other 1

Microarray probesets 3

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MGI:1915827

Summaries

All 54

Developmental Gene Expression 12

Gene Ontology 14

Phenotypes 14
Earliest

J:23342 Roark JH, et al., Breakdown of B cell tolerance in a mouse model of systemic lupus erythematosus. J Exp Med. 1995 Mar 1;181(3):1157-67
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Asb2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr117472	Chr12:103322226-103322276 (-)	9 bp
Tssr117471	Chr12:103322057-103322084 (-)	189 bp
Tssr117470	Chr12:103321994-103322005 (-)	260 bp
Tssr117469	Chr12:103313150-103313182 (-)	9,094 bp
Tssr117468	Chr12:103304762-103304806 (-)	17,476 bp
Tssr3928	Chr12:103304673-103304680 (-)	17,583 bp
Tssr117467	Chr12:103304573-103304658 (-)	17,644 bp
Tssr117466	Chr12:103304548-103304572 (-)	17,700 bp
Tssr117465	Chr12:103304514-103304540 (-)	17,733 bp
Tssr117464	Chr12:103304482-103304489 (-)	17,774 bp
Tssr117463	Chr12:103304458-103304465 (-)	17,798 bp
Tssr117462	Chr12:103303196-103303218 (-)	19,053 bp
Tssr117461	Chr12:103303176-103303195 (-)	19,074 bp
Tssr117460	Chr12:103303151-103303170 (-)	19,099 bp
Tssr117459	Chr12:103302638-103302680 (-)	19,601 bp
Tssr117458	Chr12:103302552-103302563 (-)	19,702 bp
Tssr117457	Chr12:103302402-103302415 (-)	19,851 bp
Tssr117456	Chr12:103302345-103302370 (-)	19,902 bp
Tssr117455	Chr12:103293185-103293188 (-)	29,073 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24