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Asb4 Gene Detail
Summary
  • Symbol
    Asb4
  • Name
    ankyrin repeat and SOCS box-containing 4
  • Synonyms
    8430401O13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929751
    NCBI Gene: 65255
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:5383386-5433022 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 1.99 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1343 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929751
 protein coding gene Chr6:5383386-5433022 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030435
 protein coding gene Chr6:2220607-2274611 (+)
A/J MGP_AJ_G0030408
 protein coding gene Chr6:2133557-2190309 (+)
AKR/J MGP_AKRJ_G0030335
 protein coding gene Chr6:2199301-2252404 (+)
BALB/cJ MGP_BALBcJ_G0030417
 protein coding gene Chr6:2116534-2167379 (+)
C3H/HeJ MGP_C3HHeJ_G0030131
 protein coding gene Chr6:2173250-2226910 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030872
 protein coding gene Chr6:2277714-2328778 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028083
 protein coding gene Chr6:1826657-1877086 (+)
CAST/EiJ MGP_CASTEiJ_G0029532
 protein coding gene Chr6:2165312-2221656 (+)
CBA/J MGP_CBAJ_G0030109
 protein coding gene Chr6:2354597-2409630 (+)
DBA/2J MGP_DBA2J_G0030253
 protein coding gene Chr6:2101967-2153325 (+)
FVB/NJ MGP_FVBNJ_G0030207
 protein coding gene Chr6:2096054-2145463 (+)
LP/J MGP_LPJ_G0030340
 protein coding gene Chr6:2175199-2230634 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030243
 protein coding gene Chr6:2425380-2482088 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030902
 protein coding gene Chr6:2155256-2207619 (+)
PWK/PhJ MGP_PWKPhJ_G0029247
 protein coding gene Chr6:2030357-2082634 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029083
 protein coding gene Chr6:2219084-2272009 (+)
WSB/EiJ MGP_WSBEiJ_G0029609
 protein coding gene Chr6:2149243-2205045 (+)



Homology
more
  • Human Ortholog
    ASB4, ankyrin repeat and SOCS box containing 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ASB4, ankyrin repeat and SOCS box containing 4
  • Synonyms
    ASB-4
  • Links
    NCBI Gene ID: 51666
    neXtProt AC: NX_Q9Y574
    UniProt: Q9Y574

  • Chr Location
    7q21.3; chr7:95470656-95551317 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Asb4 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene causes impaired placentation, embryonic growth arrest, reduced litter size, and pre-eclampsia like features including hypertension and albuminuria in late-stage pregnant females as well as renal defects including glomerular endotheliosis and mesangial expansion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1197
  • Tissues
    267
  • cDNA Data
    46
  • Literature Summary
    23
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 65255 NCBI Gene Model | MGI Sequence Detail 49637 C57BL/6J ±  kb
    transcript NM_001355662 RefSeq | MGI Sequence Detail 3455 ZRU/MplStud  
    polypeptide Q9WV71 UniProt | EBI | MGI Sequence Detail 426 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 59
      cDNA 46
      Primer pair 10
      Other 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1921773, MGI:2141620, MGI:2141641
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 23
      Diseases 1
      Gene Ontology 3
      Phenotypes 11
    • Earliest
      J:7396 Palmer R, et al., Genetic control of levels of murine kidney glucuronidase mRNA in response to androgen. Proc Natl Acad Sci U S A. 1983 Dec;80(24):7596-600
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory