Smoc2 MGI Mouse Gene Detail - MGI:1929881 - SPARC related modular calcium binding 2

Symbol

Smoc2
Name

SPARC related modular calcium binding 2
Synonyms

1700056C05Rik, 5430426J21Rik, Smoc2l

Feature Type

protein coding gene
IDs

MGI:1929881
NCBI Gene: 64074
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr17:14499768-14625052 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 8.95 cM, cytoband A2
Mapping Data

4 experiments

SNPs within 2kb

4136 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929881	protein coding gene	Chr17:14499768-14625052 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023164	protein coding gene	Chr17:12098880-12227940 (+)
A/J	MGP_AJ_G0023130	protein coding gene	Chr17:11922466-12048015 (+)
AKR/J	MGP_AKRJ_G0023100	protein coding gene	Chr17:11820395-11947922 (+)
BALB/cJ	MGP_BALBcJ_G0023132	protein coding gene	Chr17:11744849-11875805 (+)
C3H/HeJ	MGP_C3HHeJ_G0022893	protein coding gene	Chr17:12009570-12137232 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023573	protein coding gene	Chr17:12670872-12801115 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021085	protein coding gene	Chr17:9960145-10083181 (+)
CAST/EiJ	MGP_CASTEiJ_G0022408	protein coding gene	Chr17:11930489-12060887 (+)
CBA/J	MGP_CBAJ_G0022867	protein coding gene	Chr17:13062429-13187416 (+)
DBA/2J	MGP_DBA2J_G0023000	protein coding gene	Chr17:11648144-11774082 (+)
FVB/NJ	MGP_FVBNJ_G0022968	protein coding gene	Chr17:11440054-11566719 (+)
LP/J	MGP_LPJ_G0023074	protein coding gene	Chr17:12045837-12181415 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022989	protein coding gene	Chr17:12668927-12801792 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023609	protein coding gene	Chr17:12040187-12168249 (+)
PWK/PhJ	MGP_PWKPhJ_G0022156	protein coding gene	Chr17:11073115-11201875 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021986	protein coding gene	Chr17:11024519-11149487 (+)
WSB/EiJ	MGP_WSBEiJ_G0022469	protein coding gene	Chr17:12359699-12487590 (+)

Human Ortholog

SMOC2, SPARC related modular calcium binding 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SMOC2, SPARC related modular calcium binding 2
Synonyms

bA270C4A.1, bA37D8.1, dJ421D16.1, DTDP1, MST117, MSTP117, MSTP140, SMAP2
Links

HGNC:20323

NCBI Gene ID: 64094

neXtProt AC: NX_Q9H3U7

UniProt: Q9H3U7
Chr Location

6q27; chr6:168441151-168673445 (+) GRCh38

MGI Vertebrate Homology

Smoc2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SMOC2
Gene Tree

Smoc2

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Phenotype Summary

13 phenotypes from 1 allele in 3 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

4
Targeted

6
Incidental Mutations

APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for one KO allele exhibit protection from induced kidney fibrosis and reduced interstitial myofibroblast accumulation. Another KO allele leads to shortening and widening of the skull.

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All GO Annotations

24
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1053
Tissues

223
cDNA Data

67
Literature Summary

35

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA SMOC2

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All Sequences

53
RefSeq

4
UniProt

4
CCDS

CCDS37442.1

Ensembl

ENSMUSG00000023886 (Evidence)
NCBI Gene

64074

			Length	Strain/Species	Flank
genomic	64074	NCBI Gene Model \| MGI Sequence Detail	125285	C57BL/6J	± kb
transcript	NM_022315	RefSeq \| MGI Sequence Detail	2832	ZRU/MplStud
polypeptide	Q8CD91	UniProt \| EBI \| MGI Sequence Detail	447	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000015290 SPARC-related modular calcium-binding protein 2

(term hierarchy)
InterPro Domains

IPR051950 Developmental regulator and protease inhibitor

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

IPR002350 Kazal domain

IPR036058 Kazal domain superfamily

IPR037640 SMOC-2, extracellular calcium-binding domain

IPR019577 SPARC/Testican, calcium-binding domain

IPR000716 Thyroglobulin type-1

IPR036857 Thyroglobulin type-1 superfamily
GlyGen

Q8CD91 2 sites

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All nucleic 75

cDNA 69

Primer pair 4

Other 2

Microarray probesets 5

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MGI:1918668, MGI:1920709, MGI:1935165

Summaries

All 80

Developmental Gene Expression 35

Gene Ontology 5

Phenotypes 15
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:346632 Li H, et al., Segregation of morphogenetic regulatory function of Shox2 from its cell fate guardian role in sinoatrial node development. Commun Biol. 2024 Mar 29;7(1):385

TSS for Smoc2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr142736	Chr17:14499768-14499775 (+)	4 bp
Tssr142737	Chr17:14499793-14499812 (+)	35 bp
Tssr142738	Chr17:14619289-14619298 (+)	119,526 bp
Tssr142739	Chr17:14619497-14619508 (+)	119,735 bp
Tssr142740	Chr17:14619522-14619534 (+)	119,760 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24