As3mt MGI Mouse Gene Detail - MGI:1929882 - arsenite methyltransferase

Symbol

As3mt
Name

arsenite methyltransferase
Synonyms

2310045H08Rik, Cyt19

Feature Type

protein coding gene
IDs

MGI:1929882
NCBI Gene: 57344
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr19:46695897-46729538 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 38.97 cM, cytoband D1
Mapping Data

3 experiments

SNPs within 2kb

1023 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929882	protein coding gene	Chr19:46695124-46729538 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025216	protein coding gene	Chr19:46462920-46499173 (+)
A/J	MGP_AJ_G0025192	protein coding gene	Chr19:44133122-44166883 (+)
AKR/J	MGP_AKRJ_G0025161	protein coding gene	Chr19:45570036-45606477 (+)
BALB/cJ	MGP_BALBcJ_G0025187	protein coding gene	Chr19:44187033-44221696 (+)
C3H/HeJ	MGP_C3HHeJ_G0024947	protein coding gene	Chr19:45750515-45788768 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025630	protein coding gene	Chr19:47573666-47615668 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023044	protein coding gene	Chr19:43373372-43406988 (+)
CAST/EiJ	MGP_CASTEiJ_G0024412	protein coding gene	Chr19:45568806-45607933 (+)
CBA/J	MGP_CBAJ_G0024927	protein coding gene	Chr19:49969310-50013067 (+)
DBA/2J	MGP_DBA2J_G0025059	protein coding gene	Chr19:43953351-43985840 (+)
FVB/NJ	MGP_FVBNJ_G0025020	protein coding gene	Chr19:43739528-43776760 (+)
LP/J	MGP_LPJ_G0025145	protein coding gene	Chr19:46344512-46384986 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025051	protein coding gene	Chr19:49302460-49344661 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025688	protein coding gene	Chr19:45688909-45724854 (+)
PWK/PhJ	MGP_PWKPhJ_G0024161	protein coding gene	Chr19:43909549-43943860 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023965	protein coding gene	Chr19:44336849-44377584 (+)
WSB/EiJ	MGP_WSBEiJ_G0024482	protein coding gene	Chr19:45836652-45879239 (+)

Human Ortholog

AS3MT, arsenite methyltransferase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AS3MT, arsenite methyltransferase
Synonyms

CYT19
Links

HGNC:17452

NCBI Gene ID: 57412

neXtProt AC: NX_Q9HBK9

UniProt: Q9HBK9
Chr Location

10q24.32; chr10:102869470-102901899 (+) GRCh38

MGI Vertebrate Homology

As3mt stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AS3MT
Gene Tree

As3mt

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

3
Gene trapped

5
Targeted

4
Transgenic

1
Genomic Mutations

2 involving As3mt
Incidental Mutations

APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele have abnormalities in arsenic methylation and in the distribution/retention of orally administered arsenate.

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All GO Annotations

20
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

63
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase as3mt.2, LOC100145277

ZFIN as3mt

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All Sequences

59
RefSeq

11
UniProt

5
CCDS

CCDS50458.1

Ensembl

ENSMUSG00000003559 (Evidence)
NCBI Gene

57344

			Length	Strain/Species	Flank
genomic	ENSMUSG00000003559	Ensembl Gene Model \| MGI Sequence Detail	33642	C57BL/6J	± kb
transcript	ENSMUST00000003655	Ensembl \| MGI Sequence Detail	1736	Not Applicable
polypeptide	ENSMUSP00000003655	Ensembl \| MGI Sequence Detail	376	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000004335 arsenite methyltransferase

(term hierarchy)
EC

2.1.1.137
InterPro Domains

IPR026669 Arsenite methyltransferase-like

IPR025714 Methyltransferase domain

IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
GlyGen

Q91WU5 1 site, 1 O-linked glycan (1 site)

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All nucleic 64

cDNA 64

Microarray probesets 3

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MGI:1913858

Summaries

All 44

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 14
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for As3mt:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156803	Chr19:46695888-46695950 (+)	22 bp
Tssr156804	Chr19:46696097-46696147 (+)	225 bp
Tssr156805	Chr19:46696160-46696171 (+)	269 bp
Tssr156806	Chr19:46696174-46696197 (+)	289 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24