Tssk3 MGI Mouse Gene Detail - MGI:1929914 - testis-specific serine kinase 3

Symbol

Tssk3
Name

testis-specific serine kinase 3
Synonyms

1700014N07Rik, 4930594I21Rik, Stk22c, Stk22d, Tssk-3

Feature Type

protein coding gene
IDs

MGI:1929914
NCBI Gene: 58864
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr4:129382807-129384815 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 63.26 cM, cytoband D2.3
Mapping Data

3 experiments

SNPs within 2kb

35 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929914	protein coding gene	Chr4:129382801-129385523 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028824	protein coding gene	Chr4:131412363-131414371 (-)
A/J	MGP_AJ_G0028783	protein coding gene	Chr4:126167628-126169636 (-)
AKR/J	MGP_AKRJ_G0028736	protein coding gene	Chr4:129673681-129675689 (-)
BALB/cJ	MGP_BALBcJ_G0028806	protein coding gene	Chr4:126762824-126764832 (-)
C3H/HeJ	MGP_C3HHeJ_G0028520	protein coding gene	Chr4:129738179-129740187 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029248	protein coding gene	Chr4:136355642-136357650 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026521	protein coding gene	Chr4:119298515-119300526 (-)
CAST/EiJ	MGP_CASTEiJ_G0027953	protein coding gene	Chr4:127911811-127914464 (-)
CBA/J	MGP_CBAJ_G0028486	protein coding gene	Chr4:139728249-139730257 (-)
DBA/2J	MGP_DBA2J_G0028635	protein coding gene	Chr4:126599712-126601720 (-)
FVB/NJ	MGP_FVBNJ_G0028602	protein coding gene	Chr4:125360591-125362599 (-)
LP/J	MGP_LPJ_G0028736	protein coding gene	Chr4:131689584-131691592 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028628	protein coding gene	Chr4:144570079-144572069 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029286	protein coding gene	Chr4:130051745-130053753 (-)
PWK/PhJ	MGP_PWKPhJ_G0027674	protein coding gene	Chr4:123194748-123197443 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027501	protein coding gene	Chr4:125917215-125919221 (-)
WSB/EiJ	MGP_WSBEiJ_G0028033	protein coding gene	Chr4:130170730-130172738 (-)

Human Ortholog

TSSK3, testis specific serine kinase 3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TSSK3, testis specific serine kinase 3
Synonyms

SPOGA3, STK22C, STK22D, TSK3
Links

HGNC:15473

NCBI Gene ID: 81629

neXtProt AC: NX_Q96PN8

UniProt: Q96PN8
Chr Location

1p35.1; chr1:32351521-32364312 (+) GRCh38

MGI Vertebrate Homology

Tssk3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: TSSK3
Protein SuperFamily

Integrin-linked_kinase
Gene Tree

Tssk3

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Phenotype Summary

21 phenotypes from 4 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

2
Endonuclease-mediated

4
Radiation induced

1
Targeted

3
Genomic Mutations

4 involving Tssk3
Find Mice (IMSR)

10 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Nullizygous mutations of this gene result in male sterility associated with severe oligozoospermia, completely immotile sperm, abnormal sperm head and tail morphologies, and altered late spermiogenesis.

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All GO Annotations

37
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

736
Tissues

16
cDNA Data

8
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

36
RefSeq

6
UniProt

1
CCDS

CCDS18693.1

Ensembl

ENSMUSG00000000411 (Evidence)
NCBI Gene

58864

			Length	Strain/Species	Flank
genomic	ENSMUSG00000000411	Ensembl Gene Model \| MGI Sequence Detail	2009	C57BL/6J	± kb
transcript	ENSMUST00000000421	Ensembl \| MGI Sequence Detail	1280	Not Applicable
polypeptide	ENSMUSP00000000421	Ensembl \| MGI Sequence Detail	268	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000016772 testis-specific serine/threonine-protein kinase 3

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR042709 Testis-specific serine/threonine-protein kinase 3, catalytic domain

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All nucleic 9

cDNA 8

Primer pair 1

Microarray probesets 5

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MGI:1916640, MGI:1925477, MGI:2148928

Summaries

All 39

Developmental Gene Expression 2

Gene Ontology 9

Phenotypes 11
Earliest

J:62058 Zuercher G, et al., A novel member of the testis specific serine kinase family, tssk-3, expressed in the leydig cells of sexually mature mice. Mech Dev. 2000 May;93(1-2):175-7
Latest

J:337565 Nozawa K, et al., Testis-specific serine kinase 3 is required for sperm morphogenesis and male fertility. Andrology. 2023 Jul;11(5):826-839

TSS for Tssk3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr43507	Chr4:129384923-129384924 (-)	-109 bp
Tssr43506	Chr4:129384901-129384912 (-)	-92 bp
Tssr43505	Chr4:129384878-129384888 (-)	-68 bp
Tssr43504	Chr4:129384852-129384853 (-)	-38 bp
Tssr43503	Chr4:129384553-129384569 (-)	254 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24