Rab37 MGI Mouse Gene Detail - MGI:1929945 - RAB37, member RAS oncogene family

Symbol

Rab37
Name

RAB37, member RAS oncogene family
Synonyms

B230331O03Rik, B230354I04Rik

Feature Type

protein coding gene
IDs

MGI:1929945
NCBI Gene: 58222
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:114982257-115053062 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 80.59 cM, cytoband E2
Mapping Data

2 experiments

SNPs within 2kb

2103 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929945	protein coding gene	Chr11:114982257-115053066 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019371	protein coding gene	Chr11:119089155-119162669 (+)
A/J	MGP_AJ_G0019340	protein coding gene	Chr11:113891489-113962909 (+)
AKR/J	MGP_AKRJ_G0019310	protein coding gene	Chr11:117287018-117363053 (+)
BALB/cJ	MGP_BALBcJ_G0019314	protein coding gene	Chr11:114311371-114380792 (+)
C3H/HeJ	MGP_C3HHeJ_G0019120	protein coding gene	Chr11:117641235-117714490 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019764	protein coding gene	Chr11:122723273-122800687 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017386	protein coding gene	Chr11:110936576-111006730 (+)
CAST/EiJ	MGP_CASTEiJ_G0018675	protein coding gene	Chr11:118939153-119020864 (+)
CBA/J	MGP_CBAJ_G0019092	protein coding gene	Chr11:127563383-127646920 (+)
DBA/2J	MGP_DBA2J_G0019203	protein coding gene	Chr11:113331896-113403015 (+)
FVB/NJ	MGP_FVBNJ_G0019195	protein coding gene	Chr11:112801343-112873884 (+)
LP/J	MGP_LPJ_G0019273	protein coding gene	Chr11:119465527-119542004 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019228	protein coding gene	Chr11:126758246-126831540 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019802	protein coding gene	Chr11:117949359-118021353 (+)
PWK/PhJ	MGP_PWKPhJ_G0018439	protein coding gene	Chr11:114606665-114678738 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018231	protein coding gene	Chr11:117701387-117768951 (+)
WSB/EiJ	MGP_WSBEiJ_G0018727	protein coding gene	Chr11:117892101-117964243 (+)

Human Ortholog

RAB37, RAB37, member RAS oncogene family

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RAB37, RAB37, member RAS oncogene family
Links

HGNC:30268

NCBI Gene ID: 326624

neXtProt AC: NX_Q96AX2

UniProt: Q96AX2
Chr Location

17q25.1; chr17:74670578-74747335 (+) GRCh38

MGI Vertebrate Homology

Rab37 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: RAB37
Gene Tree

Rab37

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

2
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit reduced insulin secretion even under high glucose conditions and hyperglycemia.

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All GO Annotations

11
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

715
Tissues

6
cDNA Data

15
Literature Summary

4

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rab37

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All Sequences

52
RefSeq

7
UniProt

3
CCDS

CCDS25620.1, CCDS48979.1

Ensembl

ENSMUSG00000020732 (Evidence)
NCBI Gene

58222

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020732	Ensembl Gene Model \| MGI Sequence Detail	70806	C57BL/6J	± kb
transcript	ENSMUST00000021076	Ensembl \| MGI Sequence Detail	2210	Not Applicable
polypeptide	ENSMUSP00000021076	Ensembl \| MGI Sequence Detail	223	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000013613 Ras-related protein Rab-37

(term hierarchy)
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR001806 Small GTPase

IPR005225 Small GTP-binding protein domain

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All nucleic 16

cDNA 15

Primer pair 1

Microarray probesets 4

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MGI:2442158, MGI:3041187

Summaries

All 34

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 4
Earliest

J:61135 Masuda ES, et al., Rab37 is a novel mast cell specific GTPase localized to secretory granules. FEBS Lett. 2000 Mar 17;470(1):61-4
Latest

J:334080 Wu SY, et al., Secretory autophagy promotes RAB37-mediated insulin secretion under glucose stimulation both in vitro and in vivo. Autophagy. 2023 Apr;19(4):1239-1257

TSS for Rab37:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105836	Chr11:114982663-114982683 (+)	416 bp
Tssr105837	Chr11:115024866-115024875 (+)	42,614 bp
Tssr105838	Chr11:115044965-115045020 (+)	62,736 bp
Tssr105839	Chr11:115045028-115045036 (+)	62,775 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24