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Akr1a1 Gene Detail
Summary
  • Symbol
    Akr1a1
  • Name
    aldo-keto reductase family 1, member A1
  • Synonyms
    2610201A18Rik, Akr1a4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929955
    NCBI Gene: 58810
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:116493707-116508871 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 53.26 cM, cytoband C7
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    326 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929955
 protein coding gene Chr4:116493707-116508877 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028630
 protein coding gene Chr4:117540486-117557107 (-)
A/J MGP_AJ_G0028591
 protein coding gene Chr4:113037430-113052459 (-)
AKR/J MGP_AKRJ_G0028541
 protein coding gene Chr4:115477390-115495022 (-)
BALB/cJ MGP_BALBcJ_G0028612
 protein coding gene Chr4:113662213-113677891 (-)
C3H/HeJ MGP_C3HHeJ_G0028326
 protein coding gene Chr4:117048581-117063644 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029053
 protein coding gene Chr4:122085479-122113544 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026337
 protein coding gene Chr4:107076879-107091892 (-)
CAST/EiJ MGP_CASTEiJ_G0027760
 protein coding gene Chr4:114276733-114291834 (-)
CBA/J MGP_CBAJ_G0028293
 protein coding gene Chr4:125397825-125415315 (-)
DBA/2J MGP_DBA2J_G0028441
 protein coding gene Chr4:113669840-113685060 (-)
FVB/NJ MGP_FVBNJ_G0028409
 protein coding gene Chr4:112167921-112183429 (-)
LP/J MGP_LPJ_G0028543
 protein coding gene Chr4:117748708-117763675 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028436
 protein coding gene Chr4:130389132-130406147 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029090
 protein coding gene Chr4:116628234-116646164 (-)
PWK/PhJ MGP_PWKPhJ_G0027486
 protein coding gene Chr4:110446144-110462041 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027309
 protein coding gene Chr4:112903932-112923178 (-)
WSB/EiJ MGP_WSBEiJ_G0027839
 protein coding gene Chr4:116503732-116520857 (-)



Homology
more
  • Human Ortholog
    AKR1A1, aldo-keto reductase family 1 member A1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AKR1A1, aldo-keto reductase family 1 member A1
  • Synonyms
    ALDR1, ALR, ARM, DD3, HEL-S-6
  • Links
    NCBI Gene ID: 10327
    neXtProt AC: NX_P14550
    UniProt: P14550

  • Chr Location
    1p34.1; chr1:45550543-45570049 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    5 images
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit increased osteoporosis in response to pregnancy or castration in the absence of dietary ascorbate. Mice homozygous for a knock-out allele exhibit reduced asorbic acid levels and DL-glyceraldehyde, glucuronolactone and glucuronate reductase activity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    924
  • Tissues
    150
  • cDNA Data
    34
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 58810 NCBI Gene Model | MGI Sequence Detail 15165 C57BL/6J ±  kb
    transcript NM_021473 RefSeq | MGI Sequence Detail 1435 C57BL/6  
    polypeptide Q9JII6 UniProt | EBI | MGI Sequence Detail 325 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      cDNA 34
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1914397
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 4
      Gene Ontology 16
      Phenotypes 26
    • Earliest
      J:323240 Tulsiani DR, et al., Studies on dehydrogenases of the glucuronate-xylulose cycle in the livers of diabetic mice and rats. Diabetes. 1979 Sep;28(9):793-8
    • Latest
      J:334128 Stomberski CT, et al., A multienzyme S-nitrosylation cascade regulates cholesterol homeostasis. Cell Rep. 2022 Oct 25;41(4):111538
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory