Cst5 MGI Mouse Gene Detail - MGI:1930004

Symbol

Cst5
Name

cystatin D
Synonyms

Cst10, DD72

Feature Type

protein coding gene
IDs

MGI:1930004
NCBI Gene: 58214
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr2:149247242-149252217 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 73.80 cM, cytoband G
Mapping Data

4 experiments

SNPs within 2kb

185 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1930004	protein coding gene	Chr2:149246977-149252217 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026622	protein coding gene	Chr2:153779537-153784638 (+)
A/J	MGP_AJ_G0026587	protein coding gene	Chr2:147562455-147565953 (+)
AKR/J	MGP_AKRJ_G0026560	protein coding gene	Chr2:151801604-151806229 (+)
BALB/cJ	MGP_BALBcJ_G0026597	protein coding gene	Chr2:147985699-147989187 (+)
C3H/HeJ	MGP_C3HHeJ_G0026340	protein coding gene	Chr2:152288583-152292065 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027044	protein coding gene	Chr2:158299981-158303669 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024420	protein coding gene	Chr2:141510567-141513912 (+)
CAST/EiJ	MGP_CASTEiJ_G0025802	protein coding gene	Chr2:152643773-152647281 (+)
CBA/J	MGP_CBAJ_G0026320	protein coding gene	Chr2:164052999-164056493 (+)
DBA/2J	MGP_DBA2J_G0026454	protein coding gene	Chr2:146786669-146790145 (+)
FVB/NJ	MGP_FVBNJ_G0026419	protein coding gene	Chr2:145298949-145302432 (+)
LP/J	MGP_LPJ_G0026559	protein coding gene	Chr2:153919633-153925087 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026438	protein coding gene	Chr2:168227661-168231203 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027099	protein coding gene	Chr2:151795031-151798513 (+)
PWK/PhJ	MGP_PWKPhJ_G0025537	protein coding gene	Chr2:146506059-146509549 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025339	protein coding gene	Chr2:150896057-150899520 (+)
WSB/EiJ	MGP_WSBEiJ_G0025875	protein coding gene	Chr2:152752907-152756397 (+)

Human Ortholog

CST5, cystatin D

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CST5, cystatin D
Links

HGNC:2477

NCBI Gene ID: 1473

neXtProt AC: NX_P28325

UniProt: P28325
Chr Location

20p11.21; chr20:23875934-23879748 (-) GRCh38

MGI Vertebrate Homology

Cst5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CST5
Gene Tree

Cst5

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Cst5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele display reduced chondrocyte calcification during endochondral ossification both under physiological and pathological conditions.

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All GO Annotations

17
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

35
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

31
RefSeq

2
UniProt

1
CCDS

CCDS16853.1

Ensembl

ENSMUSG00000033156 (Evidence)
NCBI Gene

58214

			Length	Strain/Species	Flank
genomic	58214	NCBI Gene Model \| MGI Sequence Detail	4976	C57BL/6J	± kb
transcript	NM_021405	RefSeq \| MGI Sequence Detail	735	C57BL/6
polypeptide	Q9JM84	UniProt \| EBI \| MGI Sequence Detail	148	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000005967 cystatin-D

(term hierarchy)
InterPro Domains

IPR000010 Cystatin domain

IPR046350 Cystatin superfamily

IPR001713 Proteinase inhibitor I25A, stefin

IPR018073 Proteinase inhibitor I25, cystatin, conserved site

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All nucleic 35

cDNA 35

Microarray probesets 2

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MGI:7529655

Summaries

All 26

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 5
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:356509 Mo Q, et al., Identification and characterization of a supraclavicular brown adipose tissue in mice. JCI Insight. 2017 Jun 2;2(11)

TSS for Cst5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20687	Chr2:149246930-149246948 (+)	-303 bp
Tssr20688	Chr2:149247225-149247232 (+)	-13 bp
Tssr20689	Chr2:149247235-149247252 (+)	2 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24