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Dclre1a Gene Detail
Summary
  • Symbol
    Dclre1a
  • Name
    DNA cross-link repair 1A
  • Synonyms
    2810043H12Rik, mSNM1, SMN1a, SNM1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930042
    NCBI Gene: 55947
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:56517599-56536675 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 51.89 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    522 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1930042
 protein coding gene Chr19:56517593-56536716 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025265
 protein coding gene Chr19:56889120-56908161 (-)
A/J MGP_AJ_G0025241
 protein coding gene Chr19:54071386-54090435 (-)
AKR/J MGP_AKRJ_G0025210
 protein coding gene Chr19:55782396-55801410 (-)
BALB/cJ MGP_BALBcJ_G0025236
 protein coding gene Chr19:54154691-54173740 (-)
C3H/HeJ MGP_C3HHeJ_G0024996
 protein coding gene Chr19:56020509-56039545 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025679
 protein coding gene Chr19:58258656-58277697 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023091
 protein coding gene Chr19:53001330-53020732 (-)
CAST/EiJ MGP_CASTEiJ_G0024461
 protein coding gene Chr19:56043814-56062907 (-)
CBA/J MGP_CBAJ_G0024976
 protein coding gene Chr19:61136295-61167702 (-)
DBA/2J MGP_DBA2J_G0025108
 protein coding gene Chr19:53863610-53882644 (-)
FVB/NJ MGP_FVBNJ_G0025069
 protein coding gene Chr19:53564674-53583707 (-)
LP/J MGP_LPJ_G0025194
 protein coding gene Chr19:56747069-56766117 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025102
 protein coding gene Chr19:60432148-60451162 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025737
 protein coding gene Chr19:55984371-56003418 (-)
PWK/PhJ MGP_PWKPhJ_G0024209
 protein coding gene Chr19:53821339-53840757 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024012
 protein coding gene Chr19:54668913-54687867 (-)
WSB/EiJ MGP_WSBEiJ_G0024531
 protein coding gene Chr19:56129334-56148351 (-)



Homology
more
  • Human Ortholog
    DCLRE1A, DNA cross-link repair 1A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DCLRE1A, DNA cross-link repair 1A
  • Synonyms
    PSO2, SNM1, SNM1A
  • Links
    NCBI Gene ID: 9937
    neXtProt AC: NX_Q6PJP8
    UniProt: Q6PJP8

  • Chr Location
    10q25.3; chr10:113834725-113854394 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 3 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation are viable and fertile but exhibit increased sensitivity to the DNA interstrand cross-linking agent mitomycin C.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    49
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025077 Ensembl Gene Model | MGI Sequence Detail 19077 C57BL/6J ±  kb
    transcript ENSMUST00000182059 Ensembl | MGI Sequence Detail 4109 Not Applicable  
    polypeptide ENSMUSP00000138364 Ensembl | MGI Sequence Detail 1029 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      cDNA 51

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1919930, MGI:2147649
    References
    more
    • Summaries
      All 35
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory