Rps6ka4 MGI Mouse Gene Detail - MGI:1930076 - ribosomal protein S6 kinase, polypeptide 4

Rps6ka4 Gene Detail

Symbol

Rps6ka4
Name

ribosomal protein S6 kinase, polypeptide 4
Synonyms

1110069D02Rik, 90kDa, MSK2

Feature Type

protein coding gene
IDs

MGI:1930076
NCBI Gene: 56613
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr19:6806578-6818004 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 5.08 cM
Mapping Data

2 experiments

SNPs within 2kb

371 from dbSNP Build 142
Strain Annotations

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1930076	protein coding gene	Chr19:6806573-6819513 (-)
129S1/SvImJ	no annotation
A/J	no annotation
AKR/J	no annotation
BALB/cJ	no annotation
C3H/HeJ	no annotation
C57BL/6NJ	no annotation
CAROLI/EiJ	no annotation
CAST/EiJ	no annotation
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	no annotation
LP/J	no annotation
NOD/ShiLtJ	no annotation
NZO/HlLtJ	no annotation
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Human Ortholog

RPS6KA4, ribosomal protein S6 kinase A4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RPS6KA4, ribosomal protein S6 kinase A4
Synonyms

MSK2, RSK-B, S6K-alpha-4
Links

HGNC:10433

NCBI Gene ID: 8986

neXtProt AC: NX_O75676

UniProt: O75676
Chr Location

11q13.1; chr11:64359148-64372215 (+) GRCh38

MGI Vertebrate Homology

Rps6ka4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RPS6KA4
Protein SuperFamily

Ribsml_S6_kin_2
Gene Tree

Rps6ka4

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Phenotype Summary

17 phenotypes from multigenic genotypes
32 phenotype references

All Mutations and Alleles

8
Endonuclease-mediated

2
Targeted

6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

35 strains or lines available

No phenotypic information associated with mutations in this gene have been reported.

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All GO Annotations

40
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

7
Tissues

7
cDNA Data

61
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase rps6ka4

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All Sequences

39
RefSeq

5
UniProt

3
CCDS

CCDS37899.1

Ensembl

ENSMUSG00000118668 (Evidence)
NCBI Gene

56613

			Length	Strain/Species	Flank
genomic	ENSMUSG00000118668	Ensembl Gene Model \| MGI Sequence Detail	11427	C57BL/6J	± kb
transcript	ENSMUST00000239527	Ensembl \| MGI Sequence Detail	3140	Not Applicable
polypeptide	ENSMUSP00000159422	Ensembl \| MGI Sequence Detail	773	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000014285 ribosomal protein S6 kinase alpha-4

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR000961 AGC-kinase, C-terminal

IPR037714 MSK2, N-terminal catalytic domain

IPR017441 Protein kinase, ATP binding site

IPR017892 Protein kinase, C-terminal

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR016239 Ribosomal protein S6 kinase II

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 62

cDNA 61

Primer pair 1

Microarray probesets 5

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MGI:1916134, MGI:2147615

Summaries

All 70

Developmental Gene Expression 2

Gene Ontology 11

Phenotypes 32
Earliest

J:49137 Deak M, et al., Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. EMBO J. 1998 Aug 3;17(15):4426-41
Latest

J:332874 Jones MR, et al., FGFR2b signalling restricts lineage-flexible alveolar progenitors during mouse lung development and converges in mature alveolar type 2 cells. Cell Mol Life Sci. 2022 Nov 29;79(12):609

TSS for Rps6ka4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr157869	Chr19:6818229-6818246 (-)	-234 bp
Tssr157868	Chr19:6817958-6818012 (-)	19 bp
Tssr157867	Chr19:6817935-6817950 (-)	61 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24