Fads2 MGI Mouse Gene Detail - MGI:1930079

Symbol

Fads2
Name

fatty acid desaturase 2
Synonyms

2900042M13Rik, Fads2a

Feature Type

protein coding gene
IDs

MGI:1930079
NCBI Gene: 56473
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr19:10040129-10078867 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 6.36 cM, cytoband B
Mapping Data

2 experiments

SNPs within 2kb

1094 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1930079	protein coding gene	Chr19:10040129-10079110 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024837	protein coding gene	Chr19:7373214-7410374 (-)
A/J	MGP_AJ_G0024805	protein coding gene	Chr19:6870077-6908480 (-)
AKR/J	MGP_AKRJ_G0024780	protein coding gene	Chr19:7143448-7180641 (-)
BALB/cJ	MGP_BALBcJ_G0024805	protein coding gene	Chr19:6914862-6952561 (-)
C3H/HeJ	MGP_C3HHeJ_G0024571	protein coding gene	Chr19:7030175-7069902 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025253	protein coding gene	Chr19:7705748-7742931 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022680	protein coding gene	Chr19:7287793-7324573 (-)
CAST/EiJ	MGP_CASTEiJ_G0024044	protein coding gene	Chr19:6682086-6720368 (-)
CBA/J	MGP_CBAJ_G0024545	protein coding gene	Chr19:7769382-7806611 (-)
DBA/2J	MGP_DBA2J_G0024672	protein coding gene	Chr19:6883913-6921144 (-)
FVB/NJ	MGP_FVBNJ_G0024639	protein coding gene	Chr19:6918278-6955528 (-)
LP/J	MGP_LPJ_G0024759	protein coding gene	Chr19:7353102-7390289 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024666	protein coding gene	Chr19:7673208-7710401 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025301	protein coding gene	Chr19:7169544-7206700 (-)
PWK/PhJ	MGP_PWKPhJ_G0023789	protein coding gene	Chr19:6320593-6358237 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023594	protein coding gene	Chr19:6350577-6390001 (-)
WSB/EiJ	MGP_WSBEiJ_G0024106	protein coding gene	Chr19:7047414-7085228 (-)

Human Ortholog

FADS2, fatty acid desaturase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FADS2, fatty acid desaturase 2
Synonyms

D6D, DES6, FADSD6, LLCDL2, SLL0262, TU13
Links

HGNC:3575

NCBI Gene ID: 9415

neXtProt AC: NX_O95864

UniProt: O95864
Chr Location

11q12.2; chr11:61792980-61867354 (+) GRCh38

MGI Vertebrate Homology

Fads2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FADS2
Protein SuperFamily

FA_sphinglp_des
Gene Tree

Fads2

less

Phenotype Summary

54 phenotypes from 2 alleles in 2 genetic backgrounds
2 images
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Endonuclease-mediated

9
Gene trapped

4
Targeted

6
Genomic Mutations

1 involving Fads2
Incidental Mutations

APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele display absence of long-chain polyunsaturated fatty acids, infertility, arrest of spermiogenesis and folliculogenesis, and impaired platelet function.

less

All GO Annotations

12
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

806
Tissues

97
cDNA Data

92
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fads2

ZFIN fads2

less

All Sequences

47
RefSeq

2
UniProt

4
CCDS

CCDS29571.1

Ensembl

ENSMUSG00000024665 (Evidence)
NCBI Gene

56473

			Length	Strain/Species	Flank
genomic	56473	NCBI Gene Model \| MGI Sequence Detail	38739	C57BL/6J	± kb
transcript	NM_019699	RefSeq \| MGI Sequence Detail	2907	C57BL/6
polypeptide	Q9Z0R9	UniProt \| EBI \| MGI Sequence Detail	444	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000007318 acyl-CoA 6-desaturase

(term hierarchy)
EC

1.14.19.3
InterPro Domains

IPR001199 Cytochrome b5-like heme/steroid binding domain

IPR036400 Cytochrome b5-like heme/steroid binding domain superfamily

IPR012171 Fatty acid desaturase

IPR005804 Fatty acid desaturase domain

less

All nucleic 99

cDNA 95

Primer pair 3

Other 1

Microarray probesets 7

less

MGI:1920207

Summaries

All 62

Developmental Gene Expression 4

Gene Ontology 8

Phenotypes 26
Earliest

J:51797 Cho HP, et al., Cloning, expression, and nutritional regulation of the mammalian Delta-6 desaturase. J Biol Chem. 1999 Jan 1;274(1):471-7
Latest

J:346053 Zhang J, et al., Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2. Nat Commun. 2024 Mar 14;15(1):2315

TSS for Fads2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr158162	Chr19:10079196-10079203 (-)	-333 bp
Tssr158161	Chr19:10079173-10079184 (-)	-312 bp
Tssr158160	Chr19:10079091-10079114 (-)	-236 bp
Tssr158159	Chr19:10078916-10078923 (-)	-53 bp
Tssr158158	Chr19:10078865-10078896 (-)	-14 bp
Tssr5442	Chr19:10078620-10078633 (-)	240 bp
Tssr158157	Chr19:10069569-10069581 (-)	9,292 bp
Tssr158156	Chr19:10069559-10069568 (-)	9,303 bp
Tssr158155	Chr19:10069161-10069186 (-)	9,693 bp
Tssr158154	Chr19:10066328-10066363 (-)	12,521 bp
Tssr158153	Chr19:10043953-10043967 (-)	34,907 bp
Tssr158152	Chr19:10043054-10043095 (-)	35,792 bp
Tssr158151	Chr19:10042140-10042179 (-)	36,707 bp
Tssr158150	Chr19:10041510-10041564 (-)	37,330 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24