Ube2d2a MGI Mouse Gene Detail - MGI:1930715 - ubiquitin-conjugating enzyme E2D 2A

Symbol

Ube2d2a
Name

ubiquitin-conjugating enzyme E2D 2A
Synonyms

1500034D03Rik, ubc4

Feature Type

protein coding gene
IDs

MGI:1930715
NCBI Gene: 56550
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr18:35904612-35940225 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 19.24 cM
Mapping Data

1 experiment

SNPs within 2kb

598 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1930715	protein coding gene	Chr18:35904611-35942547 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024271	protein coding gene	Chr18:34106985-34144309 (+)
A/J	MGP_AJ_G0024237	protein coding gene	Chr18:32928751-32966557 (+)
AKR/J	MGP_AKRJ_G0024205	protein coding gene	Chr18:33861840-33897425 (+)
BALB/cJ	MGP_BALBcJ_G0024237	protein coding gene	Chr18:32973094-33016617 (+)
C3H/HeJ	MGP_C3HHeJ_G0024004	protein coding gene	Chr18:33893388-33928970 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024678	protein coding gene	Chr18:35326532-35364197 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022118	protein coding gene	Chr18:33028400-33063002 (+)
CAST/EiJ	MGP_CASTEiJ_G0023479	protein coding gene	Chr18:33871310-33927232 (+)
CBA/J	MGP_CBAJ_G0023972	protein coding gene	Chr18:36355293-36400040 (+)
DBA/2J	MGP_DBA2J_G0024104	protein coding gene	Chr18:32560138-32595868 (+)
FVB/NJ	MGP_FVBNJ_G0024071	protein coding gene	Chr18:32253379-32288938 (+)
LP/J	MGP_LPJ_G0024186	protein coding gene	Chr18:34155827-34191876 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024099	protein coding gene	Chr18:37570791-37606492 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024727	protein coding gene	Chr18:33693866-33730498 (+)
PWK/PhJ	MGP_PWKPhJ_G0023223	protein coding gene	Chr18:32791674-32827833 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023030	protein coding gene	Chr18:33951883-33996101 (+)
WSB/EiJ	MGP_WSBEiJ_G0023542	protein coding gene	Chr18:33625660-33662597 (+)

Human Ortholog

UBE2D2, ubiquitin conjugating enzyme E2 D2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UBE2D2, ubiquitin conjugating enzyme E2 D2
Synonyms

E2(17)KB2, PUBC1, UBC4, UBC4/5, UBCH4, UBCH5B
Links

HGNC:12475

NCBI Gene ID: 7322

neXtProt AC: NX_P62837

UniProt: P62837
Chr Location

5q31.2; chr5:139526240-139628434 (+) GRCh38

MGI Vertebrate Homology

Ube2d2a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: UBE2D2
Gene Tree

Ube2d2a

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Endonuclease-mediated

3
Gene trapped

14
Targeted

1
Incidental Mutations

APF
Find Mice (IMSR)

14 strains or lines available

Homozygous null mice display a delay in testis maturation but have normal spermatogenesis, sperm motility, and fertility.

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All GO Annotations

22
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

243

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN ube2d2

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All Sequences

77
RefSeq

4
UniProt

5
CCDS

CCDS50254.1

Ensembl

ENSMUSG00000091896 (Evidence)
NCBI Gene

56550

			Length	Strain/Species	Flank
genomic	56550	NCBI Gene Model \| MGI Sequence Detail	35614	C57BL/6J	± kb
transcript	NM_019912	RefSeq \| MGI Sequence Detail	2483	C57BL/6
polypeptide	P62838	UniProt \| EBI \| MGI Sequence Detail	147	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000016969 ubiquitin-conjugating enzyme E2 D2

(term hierarchy)
EC

2.3.2.23, 2.3.2.24
InterPro Domains

IPR023313 Ubiquitin-conjugating enzyme, active site

IPR000608 Ubiquitin-conjugating enzyme E2

IPR016135 Ubiquitin-conjugating enzyme/RWD-like

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All nucleic 243

cDNA 243

Microarray probesets 8

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MGI:1919677

Summaries

All 44

Gene Ontology 12

Phenotypes 8
Earliest

J:41090 Hatakeyama S, et al., Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases. J Biol Chem. 1997 Jun 13;272(24):15085-92
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Ube2d2a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr150551	Chr18:35904410-35904421 (+)	-196 bp
Tssr150552	Chr18:35904424-35904540 (+)	-130 bp
Tssr150553	Chr18:35904541-35904611 (+)	-36 bp
Tssr150554	Chr18:35904627-35904652 (+)	28 bp
Tssr150555	Chr18:35904663-35904668 (+)	54 bp
Tssr150556	Chr18:35904715-35904724 (+)	108 bp
Tssr150557	Chr18:35904729-35904763 (+)	134 bp
Tssr150558	Chr18:35904764-35904794 (+)	167 bp
Tssr150559	Chr18:35904950-35905007 (+)	367 bp
Tssr150560	Chr18:35905171-35905184 (+)	566 bp
Tssr150561	Chr18:35905198-35905218 (+)	596 bp
Tssr150562	Chr18:35906854-35906858 (+)	2,244 bp
Tssr150563	Chr18:35913840-35913844 (+)	9,230 bp
Tssr150564	Chr18:35928568-35928572 (+)	23,958 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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