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Trpc4ap Gene Detail
Summary
  • Symbol
    Trpc4ap
  • Name
    transient receptor potential cation channel, subfamily C, member 4 associated protein
  • Synonyms
    4833429F06Rik, D2Ertd113e, Trp4-associated protein TAP1, Trrp4ap
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930751
    NCBI Gene: 56407
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:155476197-155534304 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 77.26 cM, cytoband H2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1306 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1930751
 protein coding gene Chr2:155476191-155534304 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026739
 protein coding gene Chr2:160470241-160530038 (-)
A/J MGP_AJ_G0026705
 protein coding gene Chr2:154090417-154150402 (-)
AKR/J MGP_AKRJ_G0026676
 protein coding gene Chr2:158559019-158621105 (-)
BALB/cJ MGP_BALBcJ_G0026714
 protein coding gene Chr2:154393381-154451527 (-)
C3H/HeJ MGP_C3HHeJ_G0026457
 protein coding gene Chr2:158921866-158984227 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027163
 protein coding gene Chr2:165171143-165236157 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024533
 protein coding gene Chr2:147590144-147647053 (-)
CAST/EiJ MGP_CASTEiJ_G0025918
 protein coding gene Chr2:159234559-159299259 (-)
CBA/J MGP_CBAJ_G0026434
 protein coding gene Chr2:171171965-171241434 (-)
DBA/2J MGP_DBA2J_G0026571
 protein coding gene Chr2:153271278-153329204 (-)
FVB/NJ MGP_FVBNJ_G0026538
 protein coding gene Chr2:151648959-151707707 (-)
LP/J MGP_LPJ_G0026676
 protein coding gene Chr2:160614391-160673529 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026559
 protein coding gene Chr2:175165194-175225572 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027219
 protein coding gene Chr2:158446402-158505257 (-)
PWK/PhJ MGP_PWKPhJ_G0025652
 protein coding gene Chr2:152768663-152827802 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025455
 protein coding gene Chr2:157372966-157437453 (-)
WSB/EiJ MGP_WSBEiJ_G0025988
 protein coding gene Chr2:159333984-159397649 (-)



Homology
more
  • Human Ortholog
    TRPC4AP, transient receptor potential cation channel subfamily C member 4 associated protein
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRPC4AP, transient receptor potential cation channel subfamily C member 4 associated protein
  • Synonyms
    C20orf188, PPP1R158, TRRP4AP, TRUSS
  • Links
    NCBI Gene ID: 26133
    neXtProt AC: NX_Q8TEL6
    UniProt: Q8TEL6

  • Chr Location
    20q11.22; chr20:35002404-35092807 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Female mice heterozygous for a knock-out allele exhibit anomalies in the growth phase of the hair cycle (anagen). Mice homozygous for a different null allele exhibit resistance to high-fat diet-induced brain injury and metabolic disorder.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    17
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56407 NCBI Gene Model | MGI Sequence Detail 58108 C57BL/6J ±  kb
    transcript NM_001163452 RefSeq | MGI Sequence Detail 3219 ZRU/MplStud  
    polypeptide Q9JLV2 UniProt | EBI | MGI Sequence Detail 797 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000016694 short transient receptor potential channel 4-associated protein
      (term hierarchy)
    • InterPro Domains
      IPR016024 Armadillo-type fold
      IPR022162 Short transient receptor potential channel 4-associated protein
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 17
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1098722, MGI:2444616
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 8
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory