Insm2 MGI Mouse Gene Detail - MGI:1930787

Symbol

Insm2
Name

insulinoma-associated 2
Synonyms

mlt 1

Feature Type

protein coding gene
IDs

MGI:1930787
NCBI Gene: 56856
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr12:55646212-55648818 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 24.05 cM
Mapping Data

2 experiments

SNPs within 2kb

99 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1930787	protein coding gene	Chr12:55646212-55648871 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019751	protein coding gene	Chr12:54655131-54658232 (+)
A/J	MGP_AJ_G0019710	protein coding gene	Chr12:52696276-52699377 (+)
AKR/J	MGP_AKRJ_G0019685	protein coding gene	Chr12:54356577-54359678 (+)
BALB/cJ	MGP_BALBcJ_G0019690	protein coding gene	Chr12:53053204-53056305 (+)
C3H/HeJ	MGP_C3HHeJ_G0019495	protein coding gene	Chr12:54421483-54424581 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020142	protein coding gene	Chr12:56291108-56294209 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017762	protein coding gene	Chr12:51199065-51202193 (+)
CAST/EiJ	MGP_CASTEiJ_G0019047	protein coding gene	Chr12:49284598-49287688 (+)
CBA/J	MGP_CBAJ_G0019464	protein coding gene	Chr12:58281978-58285079 (+)
DBA/2J	MGP_DBA2J_G0019580	protein coding gene	Chr12:52606479-52609580 (+)
FVB/NJ	MGP_FVBNJ_G0019568	protein coding gene	Chr12:51903932-51907043 (+)
LP/J	MGP_LPJ_G0019652	protein coding gene	Chr12:54651361-54654462 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019606	protein coding gene	Chr12:59832035-59835134 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020176	protein coding gene	Chr12:53804300-53807399 (+)
PWK/PhJ	MGP_PWKPhJ_G0018814	protein coding gene	Chr12:46958779-46961965 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018607	protein coding gene	Chr12:48207333-48210419 (+)
WSB/EiJ	MGP_WSBEiJ_G0019098	protein coding gene	Chr12:54314134-54317240 (+)

Human Ortholog

INSM2, INSM transcriptional repressor 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

INSM2, INSM transcriptional repressor 2
Synonyms

IA-6, IA6, mlt1
Links

HGNC:17539

NCBI Gene ID: 84684

neXtProt AC: NX_Q96T92

UniProt: Q96T92
Chr Location

14q13.2; chr14:35534164-35537054 (+) GRCh38

MGI Vertebrate Homology

Insm2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: INSM2
Gene Tree

Insm2

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

1
Genomic Mutations

1 involving Insm2
Incidental Mutations

Mutagenetix , CvDC
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Knock-out mice exhibit increased fasting blood glucose levels, reduced glucose tolerance and insulin and C-peptide level, and reduced female fertility.

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All GO Annotations

15
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

799
Tissues

64
cDNA Data

8
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase insm2

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All Sequences

28
RefSeq

2
UniProt

1
CCDS

CCDS25919.1

Ensembl

ENSMUSG00000045440 (Evidence)
NCBI Gene

56856

			Length	Strain/Species	Flank
genomic	56856	NCBI Gene Model \| MGI Sequence Detail	2607	C57BL/6J	± kb
transcript	NM_020287	RefSeq \| MGI Sequence Detail	2607	C57BL/6
polypeptide	Q9JMC2	UniProt \| EBI \| MGI Sequence Detail	493	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000009063 insulinoma-associated protein 2

(term hierarchy)
InterPro Domains

IPR042972 Insulinoma-associated protein 1/2

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

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All nucleic 11

cDNA 9

Primer pair 2

Microarray probesets 2

Summaries

All 34

Developmental Gene Expression 6

Gene Ontology 6

Phenotypes 8
Earliest

J:67331 Tateno M, et al., Identification of a novel member of the snail/Gfi-1 repressor family, mlt 1, which is methylated and silenced in liver tumors of SV40 T antigen transgenic mice. Cancer Res. 2001 Feb 1;61(3):1144-53
Latest

J:334014 Li ZM, et al., Insm2 deficiency results in female infertility by disturbing steroid pathway and decreasing ovarian reserve in mice. Cell Cycle. 2022 Nov;21(21):2255-2267

TSS for Insm2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113504	Chr12:55646209-55646214 (+)	0 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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