early conceptus |
embryo ectoderm |
embryo endoderm |
embryo mesoderm |
embryo mesenchyme |
extraembryonic component |
alimentary system |
auditory system |
branchial arches |
cardiovascular system |
connective tissue |
endocrine system |
exocrine system |
hemolymphoid system |
integumental system |
limbs |
liver and biliary system |
musculoskeletal system |
nervous system |
olfactory system |
reproductive system |
respiratory system |
urinary system |
visual system |
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QTL | Genetic Location* | Genome Location (GRCm39) | Reference | QTL Note |
Ap3q | Chr4, 82.64 cM | Chr4:151654451-151654550 | J:92934 | Six genes showing differential expression in the brains of ethanol-preferring strain C57BL/6J and ethanol-avoiding strain DBA/2J were identified using mRNA differential display. Two of the six mRNA sequences matched functionally known genes, Stx12 (60 cM) on mouse Chromosome 4 and Rlpb1 (39 cM) on mouse Chromosome 7. These genes were typed in 480 (C57BL/6 x DBA/2J)F2 mice and found to segregate with the ethanol preference phenotype. Rlbp1 shows significantly higher expression in the brains of alcohol-preferring F2 mice compared to alcohol-avoiding F2 mice. This effect is stronger in (C57BL/6J x DBA/2J)F2 animals compared to the reciprocal cross (DBA/2J x C57BL/6J)F2. Rlpb1 maps near a suggestive QTL for alcohol preference (D7Mit7, 54 cM) and hypnotic dose sensitivity (Mmpv1, 28 cM) mapped by Rodriguez et al, 1995. Stx12 shows significantly lower expression in the brains of alcohol-preferring F2 mice compared to alcohol-avoiding F2 mice. This effect is stronger in (C57BL/6J x DBA/2J)F2 animals compared to the reciprocal cross (DBA/2J x C57BL/6J)F2. Stx12 maps near a previously identified alcohol preference QTLs Ap3q (81 cM) and a previously identified suggestive QTL for alcohol consumption mapped by Phillips et al, 1994. |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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