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Tusc2 Gene Detail
Summary
  • Symbol
    Tusc2
  • Name
    tumor suppressor 2, mitochondrial calcium regulator
  • Synonyms
    1190001E22Rik, Fus1, Pdap2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931086
    NCBI Gene: 80385
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:107440454-107443307 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 58.12 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    108 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1931086
 protein coding gene Chr9:107440454-107443311 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035258
 protein coding gene Chr9:109438657-109441517 (+)
A/J MGP_AJ_G0035237
 protein coding gene Chr9:105460205-105463065 (+)
AKR/J MGP_AKRJ_G0035169
 protein coding gene Chr9:108092335-108095195 (+)
BALB/cJ MGP_BALBcJ_G0035231
 protein coding gene Chr9:105129472-105132332 (+)
C3H/HeJ MGP_C3HHeJ_G0034941
 protein coding gene Chr9:108491495-108494355 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035751
 protein coding gene Chr9:112430252-112433109 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032649
 protein coding gene Chr9:102889734-102892580 (+)
CAST/EiJ MGP_CASTEiJ_G0034252
 protein coding gene Chr9:108424166-108427023 (+)
CBA/J MGP_CBAJ_G0034909
 protein coding gene Chr9:116404093-116406950 (+)
DBA/2J MGP_DBA2J_G0035070
 protein coding gene Chr9:104913928-104916785 (+)
FVB/NJ MGP_FVBNJ_G0035018
 protein coding gene Chr9:103678753-103681613 (+)
LP/J MGP_LPJ_G0035146
 protein coding gene Chr9:109644861-109647721 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035057
 protein coding gene Chr9:118016351-118019211 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035772
 protein coding gene Chr9:108363799-108366659 (+)
PWK/PhJ MGP_PWKPhJ_G0033959
 protein coding gene Chr9:105234082-105236938 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033794
 protein coding gene Chr9:108419835-108422683 (+)
WSB/EiJ MGP_WSBEiJ_G0034373
 protein coding gene Chr9:108246935-108249795 (+)



Homology
more
  • Human Ortholog
    TUSC2, tumor suppressor 2, mitochondrial calcium regulator
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TUSC2, tumor suppressor 2, mitochondrial calcium regulator
  • Synonyms
    C3orf11, FUS1, PAP, PDAP2
  • Links
    NCBI Gene ID: 11334
    neXtProt AC: NX_O75896
    UniProt: O75896

  • Chr Location
    3p21.31; chr3:50320027-50328251 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    47 phenotypes from 1 allele in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele develop signs of autoimmune disease and premature aging and exhibit multiple aging-related pathologies, chronic inflammation, low reserve respiratory capacity, altered steady-state and stimuli-induced calcium homeostasis, and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    4
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    2
  • cDNA Data
    67
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 80385 NCBI Gene Model | MGI Sequence Detail 2854 C57BL/6J ±  kb
    transcript NM_019742 RefSeq | MGI Sequence Detail 1661 C57BL/6  
    polypeptide Q9WVF8 UniProt | EBI | MGI Sequence Detail 110 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 69
      cDNA 68
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1916182, MGI:2142910
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 8
    • Earliest
      J:66052 Lerman MI, et al., The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium [In Process Citation]. Cancer Res. 2000 Nov 1;60(21):6116-33
    • Latest
      J:309768 Uzhachenko R, et al., Mitochondrial protein Fus1/Tusc2 in premature aging and age-related pathologies: critical roles of calcium and energy homeostasis. Aging (Albany NY). 2017 Mar 26;9(3):627-649
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory