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Nme4 Gene Detail
Summary
  • Symbol
    Nme4
  • Name
    NME/NM23 nucleoside diphosphate kinase 4
  • Synonyms
    2610027N22Rik, 2810024O08Rik, 5730493H09Rik, NM23-M4, non-metastatic cells 4, protein expressed in
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931148
    NCBI Gene: 56520
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:26310708-26314576 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 13.06 cM, cytoband B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    243 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1931148
 protein coding gene Chr17:26310708-26314650 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023389
 protein coding gene Chr17:25221079-25224838 (-)
A/J MGP_AJ_G0023348
 protein coding gene Chr17:24479060-24482826 (-)
AKR/J MGP_AKRJ_G0023314
 protein coding gene Chr17:24587542-24594016 (-)
BALB/cJ MGP_BALBcJ_G0023353
 protein coding gene Chr17:24701552-24705323 (-)
C3H/HeJ MGP_C3HHeJ_G0023113
 protein coding gene Chr17:24977373-24982242 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023795
 protein coding gene Chr17:26286174-26290081 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021271
 protein coding gene Chr17:21931110-21935083 (-)
CAST/EiJ MGP_CASTEiJ_G0022615
 protein coding gene Chr17:24873324-24877075 (-)
CBA/J MGP_CBAJ_G0023088
 protein coding gene Chr17:27215674-27223508 (-)
DBA/2J MGP_DBA2J_G0023218
 protein coding gene Chr17:24073554-24078527 (-)
FVB/NJ MGP_FVBNJ_G0023188
 protein coding gene Chr17:23831016-23835828 (-)
LP/J MGP_LPJ_G0023295
 protein coding gene Chr17:25509625-25513392 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023207
 protein coding gene Chr17:26786366-26791453 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023835
 protein coding gene Chr17:24919770-24923542 (-)
PWK/PhJ MGP_PWKPhJ_G0022364
 protein coding gene Chr17:22843319-22847261 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022182
 protein coding gene Chr17:22998190-23001965 (-)
WSB/EiJ MGP_WSBEiJ_G0022678
 protein coding gene Chr17:24959730-24964001 (-)



Homology
more
  • Human Ortholog
    NME4, NME/NM23 nucleoside diphosphate kinase 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NME4, NME/NM23 nucleoside diphosphate kinase 4
  • Synonyms
    NDPK-D, nm23-H4, NM23H4
  • Links
    NCBI Gene ID: 4833
    neXtProt AC: NX_O00746
    UniProt: O00746

  • Chr Location
    16p13.3; chr16:396725-410367 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    888
  • Tissues
    148
  • cDNA Data
    37
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024177 Ensembl Gene Model | MGI Sequence Detail 3869 C57BL/6J ±  kb
transcript ENSMUST00000236547 Ensembl | MGI Sequence Detail 926 Not Applicable  
polypeptide ENSMUSP00000157943 Ensembl | MGI Sequence Detail 203 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000011284 nucleoside diphosphate kinase, mitochondrial
    (term hierarchy)
  • EC
    2.7.4.6
  • InterPro Domains
    IPR001564 Nucleoside diphosphate kinase
    IPR023005 Nucleoside diphosphate kinase, active site
    IPR034907 Nucleoside diphosphate kinase-like domain
    IPR036850 Nucleoside diphosphate kinase-like domain superfamily
  • GlyGen
    Q9WV84 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 43
    cDNA 37
    Primer pair 3
    Other 3

    Microarray probesets 3
Other
Accession IDs
less
MGI:1917197, MGI:1917868, MGI:1922663
References
more
  • Summaries
    All 50
    Developmental Gene Expression 5
    Gene Ontology 8
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory