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Rab27b Gene Detail
Summary
  • Symbol
    Rab27b
  • Name
    RAB27B, member RAS oncogene family
  • Synonyms
    2310021G14Rik, B130064M09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931295
    NCBI Gene: 80718
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:70112202-70274676 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 43.89 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5420 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1931295
 protein coding gene Chr18:70112202-70274704 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024540
 protein coding gene Chr18:70430323-70601651 (-)
A/J MGP_AJ_G0024507
 protein coding gene Chr18:67363152-67517661 (-)
AKR/J MGP_AKRJ_G0024478
 protein coding gene Chr18:69316972-69481437 (-)
BALB/cJ MGP_BALBcJ_G0024507
 protein coding gene Chr18:67508814-67666250 (-)
C3H/HeJ MGP_C3HHeJ_G0024275
 protein coding gene Chr18:69440697-69606066 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024953
 protein coding gene Chr18:72256302-72418004 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022384
 protein coding gene Chr18:66677911-66827135 (-)
CAST/EiJ MGP_CASTEiJ_G0023748
 protein coding gene Chr18:69564224-69729654 (-)
CBA/J MGP_CBAJ_G0024244
 protein coding gene Chr18:74721799-74893613 (-)
DBA/2J MGP_DBA2J_G0024374
 protein coding gene Chr18:66983655-67143603 (-)
FVB/NJ MGP_FVBNJ_G0024340
 protein coding gene Chr18:66348015-66507809 (-)
LP/J MGP_LPJ_G0024458
 protein coding gene Chr18:70297586-70458338 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024370
 protein coding gene Chr18:75964622-76133300 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025001
 protein coding gene Chr18:69501285-69665678 (-)
PWK/PhJ MGP_PWKPhJ_G0023492
 protein coding gene Chr18:67338261-67494500 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023296
 protein coding gene Chr18:69657804-69813701 (-)
WSB/EiJ MGP_WSBEiJ_G0023811
 protein coding gene Chr18:69439222-69599708 (-)



Homology
more
  • Human Ortholog
    RAB27B, RAB27B, member RAS oncogene family
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAB27B, RAB27B, member RAS oncogene family
  • Synonyms
    C25KG
  • Links
    NCBI Gene ID: 5874
    neXtProt AC: NX_O00194
    UniProt: O00194

  • Chr Location
    18q21.2; chr18:54717857-54895516 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Rab27b mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 3 alleles in 3 genetic backgrounds
    11 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele exhibit impaired platelet aggregation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1043
  • Tissues
    62
  • cDNA Data
    23
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024511 Ensembl Gene Model | MGI Sequence Detail 162475 C57BL/6J ±  kb
transcript ENSMUST00000121693 Ensembl | MGI Sequence Detail 6891 Not Applicable  
polypeptide ENSMUSP00000114094 Ensembl | MGI Sequence Detail 218 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 23
    cDNA 23

    Microarray probesets 6
Other
Accession IDs
less
MGI:1916874, MGI:2445187
References
more
  • Summaries
    All 74
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 12
    Phenotypes 27
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory