Rhoj MGI Mouse Gene Detail - MGI:1931551 - ras homolog family member J

Symbol

Rhoj
Name

ras homolog family member J
Synonyms

1110005O19Rik, Arhj, TC10L, TCL

Feature Type

protein coding gene
IDs

MGI:1931551
NCBI Gene: 80837
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr12:75355096-75448230 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 32.63 cM
Mapping Data

3 experiments

SNPs within 2kb

2531 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1931551	protein coding gene	Chr12:75355087-75448230 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019846	protein coding gene	Chr12:75320333-75408518 (+)
A/J	MGP_AJ_G0019804	protein coding gene	Chr12:72503738-72589002 (+)
AKR/J	MGP_AKRJ_G0019779	protein coding gene	Chr12:74697698-74785681 (+)
BALB/cJ	MGP_BALBcJ_G0019783	protein coding gene	Chr12:72968901-73059578 (+)
C3H/HeJ	MGP_C3HHeJ_G0019589	protein coding gene	Chr12:75160081-75250558 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020235	protein coding gene	Chr12:77676162-77773874 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017853	protein coding gene	Chr12:69850207-69937624 (+)
CAST/EiJ	MGP_CASTEiJ_G0019140	protein coding gene	Chr12:69925990-70021441 (+)
CBA/J	MGP_CBAJ_G0019559	protein coding gene	Chr12:80663307-80762327 (+)
DBA/2J	MGP_DBA2J_G0019675	protein coding gene	Chr12:72370511-72456375 (+)
FVB/NJ	MGP_FVBNJ_G0019662	protein coding gene	Chr12:71191744-71275365 (+)
LP/J	MGP_LPJ_G0019747	protein coding gene	Chr12:75343125-75428691 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019701	protein coding gene	Chr12:83738133-83833552 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020271	protein coding gene	Chr12:74170155-74259317 (+)
PWK/PhJ	MGP_PWKPhJ_G0018906	protein coding gene	Chr12:66708450-66799349 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018700	protein coding gene	Chr12:68652534-68744075 (+)
WSB/EiJ	MGP_WSBEiJ_G0019192	protein coding gene	Chr12:74762176-74855904 (+)

Human Ortholog

RHOJ, ras homolog family member J

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RHOJ, ras homolog family member J
Synonyms

ARHJ, RASL7B, TC10B, TCL
Links

HGNC:688

NCBI Gene ID: 57381

neXtProt AC: NX_Q9H4E5

UniProt: Q9H4E5
Chr Location

14q23.2; chr14:63204114-63293508 (+) GRCh38

MGI Vertebrate Homology

Rhoj stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RHOJ
Gene Tree

Rhoj

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Phenotype Summary

12 phenotypes from 4 alleles in 6 genetic backgrounds
5 phenotypes from multigenic genotypes
5 images
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Targeted

7
Genomic Mutations

1 involving Rhoj
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit a slight delay in radial growth in the retina and empty basement membrane sleeves.

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All GO Annotations

31
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1048
Tissues

54
cDNA Data

66
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA RHOJ

Xenbase rhoj

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All Sequences

65
RefSeq

2
UniProt

6
CCDS

CCDS25981.1

Ensembl

ENSMUSG00000046768 (Evidence)
NCBI Gene

80837

			Length	Strain/Species	Flank
genomic	ENSMUSG00000046768	Ensembl Gene Model \| MGI Sequence Detail	93135	C57BL/6J	± kb
transcript	ENSMUST00000055390	Ensembl \| MGI Sequence Detail	2350	Not Applicable
polypeptide	ENSMUSP00000059498	Ensembl \| MGI Sequence Detail	214	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000013983 Rho-related GTP-binding protein RhoJ

(term hierarchy)
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR001806 Small GTPase

IPR003578 Small GTPase Rho

IPR005225 Small GTP-binding protein domain

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All nucleic 67

cDNA 66

Primer pair 1

Microarray probesets 4

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MGI:1914157, MGI:2145016

Summaries

All 58

Developmental Gene Expression 10

Gene Ontology 8

Phenotypes 15
Earliest

J:65771 Vignal E, et al., Characterization of TCL, a new GTPase of the rho family related to TC10 andCcdc42. J Biol Chem. 2000 Nov 17;275(46):36457-64
Latest

J:347812 Sawada M, et al., PlexinD1 signaling controls domain-specific dendritic development in newborn neurons in the postnatal olfactory bulb. Front Neurosci. 2023;17:1143130

TSS for Rhoj:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113898	Chr12:75354836-75354853 (+)	-251 bp
Tssr113899	Chr12:75355082-75355091 (+)	-9 bp
Tssr113900	Chr12:75355113-75355132 (+)	27 bp
Tssr113901	Chr12:75355161-75355182 (+)	76 bp
Tssr113902	Chr12:75355190-75355208 (+)	103 bp
Tssr113903	Chr12:75355213-75355224 (+)	123 bp
Tssr113904	Chr12:75355300-75355318 (+)	213 bp
Tssr3862	Chr12:75355322-75355336 (+)	233 bp
Tssr113905	Chr12:75355369-75355380 (+)	279 bp
Tssr113906	Chr12:75355401-75355408 (+)	309 bp
Tssr113907	Chr12:75355426-75355445 (+)	340 bp
Tssr113908	Chr12:75440775-75440805 (+)	85,694 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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