Rhoq MGI Mouse Gene Detail - MGI:1931553 - ras homolog family member Q

Symbol

Rhoq
Name

ras homolog family member Q
Synonyms

Arhq, TC10

Feature Type

protein coding gene
IDs

MGI:1931553
NCBI Gene: 104215
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr17:87270539-87307497 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 56.90 cM
Mapping Data

1 experiment

SNPs within 2kb

1216 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1931553	protein coding gene	Chr17:87270510-87307497 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024096	protein coding gene	Chr17:90315871-90352834 (+)
A/J	MGP_AJ_G0024055	protein coding gene	Chr17:87407013-87443871 (+)
AKR/J	MGP_AKRJ_G0024024	protein coding gene	Chr17:88879617-88916191 (+)
BALB/cJ	MGP_BALBcJ_G0024056	protein coding gene	Chr17:87255145-87292565 (+)
C3H/HeJ	MGP_C3HHeJ_G0023821	protein coding gene	Chr17:89741545-89779581 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024501	protein coding gene	Chr17:93442711-93481593 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021940	protein coding gene	Chr17:82565454-82602461 (+)
CAST/EiJ	MGP_CASTEiJ_G0023300	protein coding gene	Chr17:90574683-90611921 (+)
CBA/J	MGP_CBAJ_G0023795	protein coding gene	Chr17:97370617-97410174 (+)
DBA/2J	MGP_DBA2J_G0023923	protein coding gene	Chr17:85857317-85894293 (+)
FVB/NJ	MGP_FVBNJ_G0023889	protein coding gene	Chr17:85356962-85395770 (+)
LP/J	MGP_LPJ_G0024007	protein coding gene	Chr17:91101114-91139855 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023917	protein coding gene	Chr17:97273023-97311530 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024546	protein coding gene	Chr17:89396748-89433430 (+)
PWK/PhJ	MGP_PWKPhJ_G0023045	protein coding gene	Chr17:85490509-85540935 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022856	protein coding gene	Chr17:86150392-86186699 (+)
WSB/EiJ	MGP_WSBEiJ_G0023366	protein coding gene	Chr17:90240545-90277309 (+)

Human Ortholog

RHOQ, ras homolog family member Q

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RHOQ, ras homolog family member Q
Synonyms

ARHQ, HEL-S-42, RASL7A, TC10, TC10A
Links

HGNC:17736

NCBI Gene ID: 23433

neXtProt AC: NX_P17081

UniProt: P17081
Chr Location

2p21; chr2:46541806-46584688 (+) GRCh38

MGI Vertebrate Homology

Rhoq stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RHOQ
Gene Tree

Rhoq

less

Phenotype Summary

9 phenotypes from 3 alleles in 3 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

2
Targeted

5
Incidental Mutations

CvDC
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit normal brain development but show reduced axon regeneration after injury in both the peripheral and central nervous systems. Cultured hippocampal neurons display reduced axon elongation without affecting polarization.

less

All GO Annotations

46
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

712
Tissues

5
cDNA Data

141
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA RHOQ

ZFIN rhoq

less

All Sequences

41
RefSeq

2
UniProt

3
CCDS

CCDS29010.1

Ensembl

ENSMUSG00000024143 (Evidence)
NCBI Gene

104215

			Length	Strain/Species	Flank
genomic	104215	NCBI Gene Model \| MGI Sequence Detail	36959	C57BL/6J	± kb
transcript	NM_145491	RefSeq \| MGI Sequence Detail	3933	C57BL/6
polypeptide	Q8R527	UniProt \| EBI \| MGI Sequence Detail	205	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000013984 Rho-related GTP-binding protein RhoQ

(term hierarchy)
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR001806 Small GTPase

IPR003578 Small GTPase Rho

IPR005225 Small GTP-binding protein domain

less

All nucleic 143

cDNA 141

Primer pair 1

Other 1

Microarray probesets 3

Summaries

All 40

Developmental Gene Expression 4

Gene Ontology 10

Phenotypes 8
Earliest

J:65159 Joberty G, et al., The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins. Mol Cell Biol. 1999 Oct;19(10):6585-97
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rhoq:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr146158	Chr17:87268910-87268950 (+)	-1,609 bp
Tssr146159	Chr17:87270096-87270115 (+)	-433 bp
Tssr146160	Chr17:87270505-87270522 (+)	-25 bp
Tssr146161	Chr17:87270674-87270696 (+)	146 bp
Tssr146162	Chr17:87270707-87270731 (+)	180 bp
Tssr146163	Chr17:87270746-87270757 (+)	213 bp
Tssr146164	Chr17:87270758-87270774 (+)	227 bp
Tssr146165	Chr17:87270827-87270838 (+)	294 bp
Tssr146166	Chr17:87271743-87271751 (+)	1,208 bp
Tssr146167	Chr17:87288361-87288367 (+)	17,825 bp
Tssr146168	Chr17:87288511-87288525 (+)	17,979 bp
Tssr146169	Chr17:87288543-87288554 (+)	18,010 bp
Tssr146170	Chr17:87301174-87301196 (+)	30,646 bp
Tssr146171	Chr17:87305270-87305284 (+)	34,738 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24