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Nfkbiz Gene Detail
Summary
  • Symbol
    Nfkbiz
  • Name
    nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta
  • Synonyms
    Mail
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931595
    NCBI Gene: 80859
  • Alliance
    gene page
  • Transcription Start Sites
    26 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:55631740-55659018 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 33.65 cM, cytoband C1.2-C1.3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    963 from dbSNP Build 142
  • Strain Annotations
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1931595
 protein coding gene Chr16:55631738-55659262 (-)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0020807
 protein coding gene Chr16:52272075-52298668 (-)
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0021876
 protein coding gene Chr16:52634259-52662919 (-)
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    NFKBIZ, NFKB inhibitor zeta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NFKBIZ, NFKB inhibitor zeta
  • Synonyms
    ikappaBzeta, I-kappa-B-zeta, IkappaB-zeta, IKBZ, ikB-zeta, INAP, MAIL
  • Links
    NCBI Gene ID: 64332
    neXtProt AC: NX_Q9BYH8
    UniProt: Q9BYH8

  • Chr Location
    3q12.3; chr3:101827990-101861022 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Nfkbiz mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    47 phenotypes from 3 alleles in 7 genetic backgrounds
    12 phenotypes from multigenic genotypes
    2 images
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene may lead to background sensitive prenatal lethality and results in abnormal cytokine secretion, higher IgE levels, ocular surface and perioral skin inflammation accompanied by hair loss, and severe atopic dermatitis-like skin lesions.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    95
  • GO References
    28
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    760
  • Tissues
    54
  • cDNA Data
    24
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 80859 NCBI Gene Model | MGI Sequence Detail 27279 C57BL/6J ±  kb
    transcript NM_030612 RefSeq | MGI Sequence Detail 3869 C57BL/6  
    polypeptide Q9EST8 UniProt | EBI | MGI Sequence Detail 728 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 24
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2146337
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 4
      Diseases 3
      Gene Ontology 28
      Phenotypes 37
    • Earliest
      J:65974 Kitamura H, et al., MAIL, a novel nuclear IkappaB protein that potentiates LPS-induced IL-6 production. FEBS Lett. 2000 Nov 17;485(1):53-6
    • Latest
      J:352110 Daly AE, et al., Selective regulation of a defined subset of inflammatory and immunoregulatory genes by an NF-kappaB p50-IkappaBzeta pathway. Genes Dev. 2024 Jul 19;38(11-12):536-553
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory