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Fgf16 Gene Detail
Summary
  • Symbol
    Fgf16
  • Name
    fibroblast growth factor 16
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931627
    NCBI Gene: 80903
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:104807885-104818545 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 47.20 cM, cytoband C3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    181 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1931627
 protein coding gene ChrX:104807885-104820138 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035998
 protein coding gene ChrX:102531705-102542353 (+)
A/J MGP_AJ_G0035977
 protein coding gene ChrX:102312576-102323356 (+)
AKR/J MGP_AKRJ_G0035896
 protein coding gene ChrX:105584623-105602370 (+)
BALB/cJ MGP_BALBcJ_G0035967
 protein coding gene ChrX:101144989-101155811 (+)
C3H/HeJ MGP_C3HHeJ_G0035674
 protein coding gene ChrX:102973800-102984407 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036494
 protein coding gene ChrX:105453502-105464077 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033322
 protein coding gene ChrX:99785147-99795973 (+)
CAST/EiJ MGP_CASTEiJ_G0034961
 protein coding gene ChrX:87104351-87161444 (+)
CBA/J MGP_CBAJ_G0035649
 protein coding gene ChrX:108774702-108785297 (+)
DBA/2J MGP_DBA2J_G0035803
 protein coding gene ChrX:101607601-101618238 (+)
FVB/NJ MGP_FVBNJ_G0035744
 protein coding gene ChrX:100909660-100920542 (+)
LP/J MGP_LPJ_G0035896
 protein coding gene ChrX:103457128-103467778 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035776
 protein coding gene ChrX:113440229-113450887 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036520
 protein coding gene ChrX:102175582-102186208 (+)
PWK/PhJ MGP_PWKPhJ_G0034657
 protein coding gene ChrX:84649591-84659926 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034486
 protein coding gene ChrX:87855690-87866399 (+)
WSB/EiJ MGP_WSBEiJ_G0035099
 protein coding gene ChrX:100878436-100889077 (+)



Homology
more
  • Human Ortholog
    FGF16, fibroblast growth factor 16
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FGF16, fibroblast growth factor 16
  • Synonyms
    FGF-16, MF4
  • Links
    NCBI Gene ID: 8823
    neXtProt AC: NX_O43320
    UniProt: O43320

  • Chr Location
    Xq21.1; chrX:77447389-77457278 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human FGF16 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 3 alleles in 4 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Males hemizygous for one null allele show reduced fetal cardiomyocyte proliferation and postnatal cardiomyocyte numbers. Males hemizygous for another null allele die in midgestation with craniofacial and heart defects including cardiac hemorrhage, chamber dilation, thin walls and poor trabeculation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1013
  • Tissues
    235
  • cDNA Data
    5
  • Literature Summary
    27
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031230 Ensembl Gene Model | MGI Sequence Detail 10661 C57BL/6J ±  kb
    transcript ENSMUST00000033581 Ensembl | MGI Sequence Detail 1645 Not Applicable  
    polypeptide ENSMUSP00000033581 Ensembl | MGI Sequence Detail 207 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 6
      Primer pair 8
      Other 3

      Microarray probesets 2
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 27
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:45662 Miyake A, et al., Structure and expression of a novel member, FGF-16, on the fibroblast growth factor family. Biochem Biophys Res Commun. 1998 Feb 4;243(1):148-52
    • Latest
      J:343328 Xie Z, et al., ZBTB20 is essential for cochlear maturation and hearing in mice. Proc Natl Acad Sci U S A. 2023 Jun 13;120(24):e2220867120
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory