Chia1 MGI Mouse Gene Detail - MGI:1932052

Symbol

Chia1
Name

chitinase, acidic 1
Synonyms

2200003E03Rik, AMCase, Chia, YNL

Feature Type

protein coding gene
IDs

MGI:1932052
NCBI Gene: 81600
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr3:106020698-106039434 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 46.49 cM, cytoband F3
Mapping Data

2 experiments

SNPs within 2kb

501 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1932052	protein coding gene	Chr3:106020545-106039436 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027729	protein coding gene	Chr3:107504568-107527594 (+)
A/J	MGP_AJ_G0027689	protein coding gene	Chr3:104075930-104096149 (+)
AKR/J	MGP_AKRJ_G0027654	protein coding gene	Chr3:106669836-106688554 (+)
BALB/cJ	MGP_BALBcJ_G0027701	protein coding gene	Chr3:103850915-103868450 (+)
C3H/HeJ	MGP_C3HHeJ_G0027431	protein coding gene	Chr3:107002045-107023067 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028145	protein coding gene	Chr3:111523629-111553073 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025485	protein coding gene	Chr3:100129480-100148013 (+)
CAST/EiJ	MGP_CASTEiJ_G0026887	protein coding gene	Chr3:106154238-106173866 (+)
CBA/J	MGP_CBAJ_G0027406	protein coding gene	Chr3:115284292-115308234 (+)
DBA/2J	MGP_DBA2J_G0027548	protein coding gene	Chr3:103309751-103328234 (+)
FVB/NJ	MGP_FVBNJ_G0027516	protein coding gene	Chr3:101234323-101251917 (+)
LP/J	MGP_LPJ_G0027655	protein coding gene	Chr3:108894324-108915129 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027546	protein coding gene	Chr3:121380285-121410569 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028200	protein coding gene	Chr3:106228894-106249097 (+)
PWK/PhJ	MGP_PWKPhJ_G0026613	protein coding gene	Chr3:103097169-103116155 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026434	protein coding gene	Chr3:104225156-104243603 (+)
WSB/EiJ	MGP_WSBEiJ_G0026967	protein coding gene	Chr3:106765662-106786902 (+)

Human Ortholog

CHIA, chitinase acidic

Vertebrate Orthologs

6

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CHIA, chitinase acidic
Synonyms

AMCASE, CHIT2, TSA1902
Links

HGNC:17432

NCBI Gene ID: 27159

neXtProt AC: NX_Q9BZP6

UniProt: Q9BZP6
Chr Location

1p13.2; chr1:111290851-111320566 (+) GRCh38

MGI Vertebrate Homology

Chia1 stringent orthology
1 human;1 mouse;1 rat;4 zebrafish
HCOP

vertebrate homology predictions: CHIA
Gene Tree

Chia1

Diseases

1 with human CHIA associations

				Human Disease	Mouse Models
				asthma IDs asthma DOID:2841 DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 ICD10CM:J45 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 UMLS_CUI:C0004096

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

7
Transgenic

2
Genomic Mutations

2 involving Chia1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

53 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous knockout causes increased neutrophil and lymphocyte counts in bronchoalveolar lavage in certain pulmonary allergen exposure experiments, but immune response to various pulmonary allergen exposures is unchanged.

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All GO Annotations

27
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

808
Tissues

96
cDNA Data

692
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase chia

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All Sequences

41
RefSeq

2
UniProt

2
CCDS

CCDS38585.1

Ensembl

ENSMUSG00000062778 (Evidence)
NCBI Gene

81600

			Length	Strain/Species	Flank
genomic	81600	NCBI Gene Model \| MGI Sequence Detail	18737	C57BL/6J	± kb
transcript	NM_023186	RefSeq \| MGI Sequence Detail	1557	FVB/N
polypeptide	Q91XA9	UniProt \| EBI \| MGI Sequence Detail	473	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005425 acidic mammalian chitinase

(term hierarchy)
PDB

8FG5, 8FG7, 8FR9, 8FRA, 8FRB, 8FRC, 8FRD, 8FRG, 8GCA
EC

3.2.1.14
InterPro Domains

IPR011583 Chitinase II

IPR029070 Chitinase insertion domain superfamily

IPR002557 Chitin binding domain

IPR036508 Chitin binding domain superfamily

IPR001223 Glycoside hydrolase family 18, catalytic domain

IPR017853 Glycoside hydrolase superfamily

IPR050314 Glycosyl Hydrolase Family 18

IPR001579 Glycosyl hydrolases family 18 (GH18) active site

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All nucleic 693

cDNA 692

Primer pair 1

Microarray probesets 3

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MGI:1913535

Summaries

All 59

Developmental Gene Expression 3

Diseases 1

Gene Ontology 8

Phenotypes 23
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Chia1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr31104	Chr3:106020677-106020694 (+)	-12 bp
Tssr998	Chr3:106038236-106038239 (+)	17,540 bp
Tssr31105	Chr3:106039176-106039185 (+)	18,483 bp
Tssr31106	Chr3:106039241-106039276 (+)	18,561 bp
Tssr31107	Chr3:106039280-106039375 (+)	18,630 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24