Tnxb MGI Mouse Gene Detail - MGI:1932137

Symbol

Tnxb
Name

tenascin XB
Synonyms

TN-MHC, Tnx

Feature Type

protein coding gene
IDs

MGI:1932137
NCBI Gene: 81877
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr17:34879431-34938789 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 18.24 cM
Mapping Data

2 experiments

SNPs within 2kb

1 from dbSNP Build 142
Strain Annotations

13
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1932137	protein coding gene	Chr17:34879427-34938789 (+)
129S1/SvImJ	no annotation
A/J	MGP_AJ_G0023549	protein coding gene	Chr17:33558724-33593775 (+)
AKR/J	MGP_AKRJ_G0023514	protein coding gene	Chr17:33971507-34070969 (+)
BALB/cJ	MGP_BALBcJ_G0023553	protein coding gene	Chr17:33713620-33772194 (+)
C3H/HeJ	MGP_C3HHeJ_G0023313	protein coding gene	Chr17:34372318-34456882 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023993	protein coding gene	Chr17:36081758-36233660 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021472	protein coding gene	Chr17:31448006-31517888 (+)
CAST/EiJ	no annotation
CBA/J	MGP_CBAJ_G0023291	protein coding gene	Chr17:37588924-37653805 (+)
DBA/2J	MGP_DBA2J_G0023419	protein coding gene	Chr17:32842871-32929679 (+)
FVB/NJ	MGP_FVBNJ_G0023386	protein coding gene	Chr17:32768899-32825091 (+)
LP/J	MGP_LPJ_G0023497	protein coding gene	Chr17:35014423-35088412 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023409	protein coding gene	Chr17:36486978-36517776 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024036	protein coding gene	Chr17:34303690-34358667 (+)
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Human Ortholog

TNXB, tenascin XB

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TNXB, tenascin XB
Synonyms

EDS3, EDSCLL, EDSCLL1, HXBL, TENX, TN-X, TNX, TNXB1, TNXB2, TNXBS, VUR8, XB, XBS
Links

HGNC:11976

NCBI Gene ID: 7148

neXtProt AC: NX_P22105

UniProt: P22105
Chr Location

6p21.33-p21.32; chr6:32041153-32115334 (-) GRCh38

MGI Vertebrate Homology

Tnxb stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: TNXB
Gene Tree

Tnxb

Diseases

2 with human TNXB associations

				Human Disease	Mouse Models
				Ehlers-Danlos syndrome IDs Ehlers-Danlos syndrome DOID:13359 DOID:14696 ICD10CM:Q79.6 ICD9CM:756.83 MESH:D004535 NCI:C34568 OMIM:PS130000 UMLS_CUI:C0013720
				vesicoureteral reflux IDs vesicoureteral reflux DOID:9620 ICD10CM:N13.7 ICD9CM:593.7 MESH:D014718 NCI:C84467 OMIM:193000 OMIM:314550 OMIM:610878 OMIM:613674 OMIM:614317 OMIM:614318 OMIM:614319 OMIM:614674 OMIM:615390 OMIM:615963 ORDO:289365 UMLS_CUI:C0042580

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

9 phenotypes from 3 alleles in 3 genetic backgrounds
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

2
Targeted

6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

185 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice have stretchy skin, similar to patients with human Ehlers-Danlos syndrome.

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All GO Annotations

25
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

792
Tissues

61
cDNA Data

23
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tnxb

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All Sequences

55
RefSeq

16
UniProt

8
CCDS

CCDS28656.2

Ensembl

ENSMUSG00000033327 (Evidence)
NCBI Gene

81877

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033327	Ensembl Gene Model \| MGI Sequence Detail	59359	C57BL/6J	± kb
transcript	ENSMUST00000238967	Ensembl \| MGI Sequence Detail	13300	Not Applicable
polypeptide	ENSMUSP00000158977	Ensembl \| MGI Sequence Detail	4356	Not Applicable

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UniProt

8 Sequences
InterPro Domains

IPR000742 EGF-like domain

IPR013111 EGF-like domain, extracellular

IPR050991 Extracellular Matrix Regulatory Proteins

IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain

IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1

IPR020837 Fibrinogen, conserved site

IPR036056 Fibrinogen-like, C-terminal

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR013783 Immunoglobulin-like fold

IPR041161 Tenascin, EGF-like domain
GlyGen

A0A5F8MPH8 5 sites, 4 N-linked glycans (4 sites), 1 O-linked glycan (1 site)

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All nucleic 29

Genomic 1

cDNA 23

Primer pair 2

Other 3

Microarray probesets 3

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MGD-MRK-18691, MGI:101866

Summaries

All 74

Developmental Gene Expression 12

Gene Ontology 13

Phenotypes 24
Earliest

J:36890 Saga Y, et al., Mice develop normally without tenascin. Genes Dev. 1992 Oct;6(10):1821-31
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tnxb:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr144107	Chr17:34879431-34879490 (+)	30 bp
Tssr144108	Chr17:34880584-34880591 (+)	1,157 bp
Tssr144109	Chr17:34880626-34880635 (+)	1,200 bp
Tssr144110	Chr17:34900378-34900390 (+)	20,953 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24